A5108050278- Pharmacological Effects of Natural Compounds
- HIV Research and Treatment
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Plant Molecular Biology Research
- Parathyroid Disorders and Treatments
- Ginger and Zingiberaceae research
- Natural product bioactivities and synthesis
- Genomics and Chromatin Dynamics
- Inflammatory mediators and NSAID effects
- Cardiac Arrhythmias and Treatments
- RNA Interference and Gene Delivery
- Phytochemistry and Biological Activities
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Fungal Biology and Applications
- Lipid metabolism and biosynthesis
- Plant nutrient uptake and metabolism
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Advanced Data Storage Technologies
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Cardiac pacing and defibrillation studies
Gannan Medical University
2013-2025
Dalian University of Technology
2024
Dalian Ocean University
2024
Beijing Anzhen Hospital
2024
Capital Medical University
2021-2024
Jiamusi University
2022-2024
University of Jinan
2020-2024
South China Normal University
2020-2024
Beijing Institute of Technology
2024
First Hospital of Jilin University
2024
Journal Article Nephrotoxicity and Renal Cell Carcinoma After Use of Iron- Aluminum-Nitrilotriacetate Complexes in Rats Get access Yoshihito Ebina, Ebina Search for other works by this author on: Oxford Academic PubMed Google Scholar Shigeru Okada, Okada Shuji Hamazaki, Hamazaki Fumio Ogino, Ogino Jia-li Li, Li Osamu Midorikawa JNCI: the National Cancer Institute, Volume 76, Issue 1, January 1986, Pages 107–113, https://doi.org/10.1093/jnci/76.1.107 Published: 01 1986 history Received: 28...
Abstract Exacerbation of macrophage-mediated inflammation contributes to pathogenesis various inflammatory diseases, but the immunometabolic programs underlying regulation macrophage activation are unclear. Here we show that V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein is expressed by resting macrophages, inhibits in response lipopolysaccharide. Vsig4 −/− mice susceptible high-fat diet-caused obesity and murine hepatitis virus strain-3 (MHV-3)-induced...
Six new DIKETOPIPERAZINE alkaloids aspergiamides A-F (1-6), together with ten known (7-16), were isolated from the mangrove endophytic fungus Aspergillus sp. 16-5c. The structures of compounds elucidated based on 1D/2D NMR spectroscopic and HR-ESIMS data analyses. absolute configurations established experimental calculated ECD data. All evaluated for antidiabetic activity against α-glucosidase PTP1B enzyme. bioassay results disclosed 1 9 exhibited significant inhibitory IC50 values 18.2 7.6...
One previously undescribed alkaloid, named penifuranone A (1), and three known compounds (2–4) were isolated from the mangrove endophytic fungus Penicillium crustosum SCNU-F0006. The structure of new alkaloid (1) was elucidated based on extensive spectroscopic data analysis single-crystal X-ray diffraction analysis. Four natural isolates one synthetic derivative A, compound 1a, screened for their antimicrobial, antioxidant, anti-inflammatory activities. Bioassays revealed that exhibited...
Adipocyte infiltration in pancreatic cancer (PC) has been demonstrated to be independently associated with PC risk and an active contributor tumor progression. However, date, little is known about these unique tumor‑surrounding adipocytes, or their response cells. The present study utilized vitro indirect coculture model which the phenotypic changes of adipocytes following exposure cells were directly observed. RNA‑sequencing was performed on 3T3‑L1 cultured without Panc‑1 cells, significant...
Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is one main active ingredients hull mangosteen. The objective study was to elucidate its anti-cancer possible mechanism. α-Mangostin separated structurally confirmed. MTT method used check effect mangostin on breast cancer cell proliferation. Then transcriptional activity RXRα tested by dual-luciferase reporter gene assay. And Western blot (WB) detect expression apoptosis-related proteins or...
Whether berberine mediates its anti-inflammatory and blood sugar lipid-lowering effects solely by adjusting the structure of gut microbiota or first directly regulating expression host pro-inflammatory proteins activation macrophages subsequently acting on microbiota, is currently unclear. To clarify mechanism berberine-mediated regulation metabolism, we constructed an obese mouse model using SPF-grade C57BL/6J male mice conducted a systematic study liver tissue pathology, inflammatory...
A high-purine diet can cause hyperuricemia and destroy the microbial composition of gut microbiota. Both folic acid zinc significantly reduce uric levels alleviate hyperuricemia. However, whether underlying mechanisms are associated with regulation microbiota remain unknown. To explore alterations related to treatment in rats our study. hyperuricemic rat model was established a diet. The effects on were evaluated. Alterations treatments evaluated by sequencing using Illumina MiSeq system....
Objective To investigate the expression of short-chain fatty acids (SCFAs)—metabolites intestinal flora—in gestational complications diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis pregnancy (ICP), its clinical significance. Methods Targeted metabonomics was used to detect SCFAs in serum 28 GDM pregnant women, PE 29 ICP 27 healthy women (NP); their changes were observed; correlation between characteristics studied; potential as biomarkers for diagnosis evaluated....
Backgrounds: Diminished ovarian reserve (DOR) contributes significantly to female subfertility. Bushen Cuyun Recipe (BCR, Tradename Yueliang Yin), a marketed product in China, showed potent effects treatment of subfertility clinical practices traditional Chinese medicine (TCM). In this study, we aimed investigate chemical compositions, efficacy scientific evidences and pharmacological mechanisms BCR DOR treatments. Methods: Chemical compositions were determined by UHPLC-LTQ-Orbitrap MS...
Four new polyketide compounds, including two unique isocoumarins penicillol A (1) and B (2) featuring with spiroketal rings, citreoviridin derivatives H (3) I (4), along four known analogues were isolated from the mangrove endophytic fungus Penicillium sp. BJR-P2. Their structures elucidated by extensive spectroscopic methods. The absolute configurations of compounds 1-4 based on electronic circular dichroism (ECD) calculations, DP4+ analysis, single-crystal X-ray diffraction are presented....
Preeclampsia (PE) is a complex pregnancy-related hypertensive disorder leading to multiorgan dysfunction. It has high maternal, fetal, and neonatal morbidity mortality rates. The study of gut microbiota its metabolites in PE deserves further exploration. Thirty-eight pregnant women with 29 healthy the third trimester their pregnancy were recruited this study. We used targeted metabolomics approach evaluate short-chain fatty acids (SCFAs) serum samples. correlation between SCFAs clinical...