A5050091041- Pregnancy and preeclampsia studies
- Lower Extremity Biomechanics and Pathologies
- Analytical chemistry methods development
- Birth, Development, and Health
- Sports injuries and prevention
- Gestational Diabetes Research and Management
- Analytical Chemistry and Chromatography
- Pelvic and Acetabular Injuries
- Pregnancy-related medical research
- Antibiotics Pharmacokinetics and Efficacy
- Maternal and fetal healthcare
- Sports Performance and Training
- Clay minerals and soil interactions
- Antioxidant Activity and Oxidative Stress
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Vitamin C and Antioxidants Research
- Microplastics and Plastic Pollution
- Melamine detection and toxicity
- Effects and risks of endocrine disrupting chemicals
- Heme Oxygenase-1 and Carbon Monoxide
- Neurogenetic and Muscular Disorders Research
- Foot and Ankle Surgery
- Neonatal and fetal brain pathology
Ningbo University
2014-2024
Ningbo University Affiliated Hospital
2009-2024
Astaxanthin is a powerful antioxidant that possesses potent protective effects against various human diseases and physiological disorders. However, the mechanisms underlying its functions in cells are not fully understood. In present study, of astaxanthin on reactive oxygen species (ROS) production enzyme activity, as well mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3-kinase (PI3K)/Akt, nuclear factor erythroid 2-related 2 (Nrf-2)/heme oxygenase-1 (HO-1) pathways...
Pathological scarring is an abnormal outcome of wound healing, which often manifests as excessive proliferation and transdifferentiation fibroblasts (FBs), deposition the extracellular matrix. FBs are most important effector cells involved in healing scar formation. The factors that promote pathological formation act on function FB. In this study, we describe lead to FB terms microenvironment, signalling pathways, epigenetics, autophagy. These findings suggest understanding causes may aid...
Perfluorohexanesulfonic acid (PFHxS), an emerging short-chain per- and polyfluoroalkyl substance, has been frequently detected in aquatic environments. Adverse outcome pathway studies have shown that perfluorinated compounds impair lipid homeostasis through peroxisome proliferator activated receptors (PPARs). However, many of these were performed at high concentrations may thus be a result overt toxicity. To better characterize the molecular key events PFHxS to biota, early life-stage...
The change in the characteristics of gut microbiota is linked to gestational diabetes mellitus (GDM). However, whether and how microbiota-derived metabolites GDM uncertain. Here, we aimed determine associations between GDM.
Objective To investigate the expression of short-chain fatty acids (SCFAs)—metabolites intestinal flora—in gestational complications diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis pregnancy (ICP), its clinical significance. Methods Targeted metabonomics was used to detect SCFAs in serum 28 GDM pregnant women, PE 29 ICP 27 healthy women (NP); their changes were observed; correlation between characteristics studied; potential as biomarkers for diagnosis evaluated....
To investigate the antioxidative effect of astaxanthin on Nω-nitro-L-arginine methyl ester (L-NAME)-induced preeclamptic rats. Cell survival, level reactive oxygen species (ROS) and changes in mitochondrial membrane potential (MMP) were examined H2O2-treated human umbilical vein endothelial cells (HUVECs). The Sprague-Dawley (SD) rat model was established by injection L‑NAME treatment with astaxanthin. activities malondialdehyde (MDA), superoxide dismutase (SOD) nitric oxide synthase (NOS)...
The objective of this study was to examine the effects running fatigue on symmetry lower limb biomechanical parameters in eighteen male amateur runners. marker trajectories and ground reaction forces were collected before after running-induced protocol. Symmetry angles (SA) used quantify each parameter. Normality tests Paired sample T-tests carried out detect bilateral differences SA between pre- post-fatigue. One-dimensional statistical parameter mapping (SPM_1d) compare with characteristic...
With the increased popularity of running, many studies have been conducted into footwears that are highly related to running performance and running-related injuries. Previous investigated different shoe types shoes with heel-to-toe drops (HTDs). However, no research was found in investigating negative values HTD. Therefore, aim this study determine acute effect HTD speed on lower limb biomechanics strike pattern recreational runners. Thirteen male runners wearing two HTDs (-8 8 mm)...
Preeclampsia (PE) is a complex pregnancy-related hypertensive disorder leading to multiorgan dysfunction. It has high maternal, fetal, and neonatal morbidity mortality rates. The study of gut microbiota its metabolites in PE deserves further exploration. Thirty-eight pregnant women with 29 healthy the third trimester their pregnancy were recruited this study. We used targeted metabolomics approach evaluate short-chain fatty acids (SCFAs) serum samples. correlation between SCFAs clinical...
In this work, an ampholine-functionalized hybrid organic–inorganic silica sorbent was successfully used to extract melamine from a milk formula sample by hydrophilic interaction solid-phase extraction protocol. Primary factors affecting the efficiency of material such as solvent, elution loading volume, and volume have been thoroughly optimized. Under optimized conditions, recoveries spiked in samples ranged 86.2 101.8% with relative standard deviations 4.1–9.4% (n = 3). The limit detection...
<strong>Background:</strong> Pelvic floor dysfunction (PFD) seriously affects the patients' quality of life, and its incidence is closely related to pregnancy delivery. muscle training (PFMT) a conservative treatment PFD. For decades, different researchers have conducted PFMT research on female groups. However, efficacy for pregnant postpartum women controversial. Therefore, this article aimed systematic review them. This reviewed relationship between occurrence development PFD during...
<abstract> The purpose of this study was to explore whether the Nomogram, which constructed by combining Deep learning and Radiomic features T2-weighted MR images with Clinical factors (NDRC), could accurately predict placenta invasion. This retrospective included 72 pregnant women pathologically confirmed invasion 40 normal placenta. After 24 gestational weeks, all participants underwent magnetic resonance imaging. uterus regions were segmented in on sagittal T2WI. Ninety-three radiomics...