A5088326341- Immune Response and Inflammation
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Antimicrobial Peptides and Activities
- Salivary Gland Disorders and Functions
- Glycosylation and Glycoproteins Research
- Sphingolipid Metabolism and Signaling
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Porphyrin and Phthalocyanine Chemistry
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Advanced Proteomics Techniques and Applications
- Ear and Head Tumors
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Marine Sponges and Natural Products
- Diabetic Foot Ulcer Assessment and Management
- Teratomas and Epidermoid Cysts
- SARS-CoV-2 detection and testing
- Pressure Ulcer Prevention and Management
- Medical and Biological Sciences
University of the Pacific
2015-2022
University of Washington
2009-2010
Rutgers, The State University of New Jersey
2010
Indiana University
1998
Matsumoto Dental University
1986-1995
Although it is known that diabetes impairs oral wound healing, relatively little about the cellular parameters affected, particularly in connective tissue. This study investigated hypothesis tissue formation healing gingiva, and impaired associated with factors decrease fibroblast numbers. Full-thickness wounds were created palatal gingiva of type 1 2 diabetic normoglycemic mice. Five days after wounding, mice had less epithelial coverage, new formation, reduced density (p < 0.05)....
Epithelial cells and dendritic (DCs) both initiate contribute to innate immune responses bacteria. However, much less is known about the coordinated regulation of between GECs cells, particularly DCs in oral cavity. The present study was conducted investigate whether their are bacteria-specific β-defensin antimicrobial peptides hBD1, hBD2 hBD3 were expressed by immature as well gingival epithelial (GECs). HBD1, upregulated while response bacterial stimulation. Responses cell types...
Abstract Osteoprotegerin regulates not only DC survival but also the nature of DC-dependent inflammatory responses. The TNF family ligand, RANKL, and its two TNFR receptors, RANK OPG, enable coordinated regulation between skeletal immune systems. Relatively little is known about how OPG influences RANKL-RANK interactions for DCs. Here, we show that KO bone marrow-derived DCs survive better produce more TNF-α, IL-12p40, IL-23 in response to Escherichia coli LPS than WT RANKL induced on within...
Background Material and Methods Results Conclusions.
Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized inflammatory condition with single- or multi-organ involvement. The characterized by tumefactive lesions dense IgG4 plasmacytic infiltration (an elevated IgG4+/IgG+ cell ratio of > 40 %), storiform fibrosis, and obliterative phlebitis, without serum levels. diagnostic criteria for IgG4-RD, proposed in 2011, were quite comprehensive practical; however, it important to remember that other diseases, such as hyper-interleukin...
Background/aims: The oral cavity harbors a diverse and complex microbial community. Bacteria accumulate on both the hard soft tissues in sessile biofilms engage host an intricate cellular dialog, which normally constrains bacteria to state of commensal harmony. Dendritic cells (DCs) are likely balance tolerance active immunity microorganisms as part chronic inflammatory responses. While role played by DCs maintaining intestinal homeostasis has been investigated extensively, relatively little...
Survivin, a member of the inhibitor apoptosis family, is overexpressed in most human tumors, but undetectable normal adult tissues. It promising target molecule cancer treatment, as interference its function promotes apoptosis. Artepillin C, major, biologically active ingredient Brazilian propolis, possesses anticancer activity against several cells with different tissue origins. However, little known about bioactivity on oral squamous cell carcinoma or effect survivin expression. The aim...
The feasibility of using the hamster cheek pouch/dimethyl-benzanthracene (DMBA) system as an experimental model lymphatic metastasis was investigated. Forty male Syrian golden hamsters treated with DMBA were divided into two equal groups--one surgical excision their tumors and a control group without tumor excision. In group, animals received three applications/week to left pouch 0.3% in acetone for 14 weeks. Following three-week observation period, excised at base, killed after four weeks...
Viral vectors are used commonly in gene therapy trials, but their potential toxic effects a serious concern. Identification of highly efficient nonviral may alleviate these effects. Results & methodology: We compared the abilities TransfeX, TransIT-LT1 and adenovirus to deliver firefly luciferase green fluorescent protein genes into HeLa cervical carcinoma, HSC-3 H357 oral squamous cell carcinoma cells. TransfeX mediated fourfold higher expression cells than adenovirus, even at highest...
We demonstrated for the first time that 9,10-dimethyl-l,2-benzanthracene (DMBA)-treated hamsters showed hypertriglyceridemia followed by cachexia. Hypertriglyceridemia is believed to be caused in part decreased lipoprotein lipase (LPL) activity, and cytokines such as tumor necrosis factor (TNF)-a. In addition, TNF-a action associated with LPL activity. Therefore, we determined content of triglyceride (TG), LPL, serum from DMBA-treated hamsters. Elevated TG concentration tumor-bearing was...
In general, it has been reported that peripheral ameloblastoma are less common and aggressive than their intraosseous counter parts. this paper, a case of ameloblastoma, which appear in 63-year-old Japanese male, is described. The present showed unusual invasive features. Based upon the clinical course histopathological features, biological behavior neoplasm discused.
An approach to curing HIV/AIDS is specifically kill all infected cells. Because the lectins, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis (GNA), are potent inhibitors of HIV infection bind oligomannans on Env protein, we hypothesized that they would cells expressing protein their plasma membrane. Flow cytometry experiments indicated, however, these lectins equivalently both Env-expressing control without Env.
Cancer gene therapy involves the introduction of therapeutic genes into malignant cells. The use lipid-based nonviral vectors is a promising approach to delivery since it avoids potential immune effects presented with viral vectors.. However, transfection efficiency non-viral needs be improved achieve adequate transgene expression in most cancer In particular, oral squamous cell carcinoma cells are highly resistant by vectors. We investigated ability two novel reagents deliver for firefly...