A5019469550- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neuroscience and Music Perception
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Hearing, Cochlea, Tinnitus, Genetics
- Stress Responses and Cortisol
- Hearing Loss and Rehabilitation
- Non-Invasive Vital Sign Monitoring
- Cardiovascular and Diving-Related Complications
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Cancer, Stress, Anesthesia, and Immune Response
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Muscle activation and electromyography studies
- Visual perception and processing mechanisms
- Multisensory perception and integration
- Pluripotent Stem Cells Research
City University of Hong Kong
2016-2025
Chinese Academy of Sciences
2007-2025
City University of Hong Kong, Shenzhen Research Institute
2017-2024
University of Hong Kong
2007-2023
Shanghai Institute for Science of Science
2023
Hong Kong Polytechnic University
2008-2021
Hong Kong University of Science and Technology
2019
Lanzhou University
2017
University of Electronic Science and Technology of China
2016
Guangzhou Institutes of Biomedicine and Health
2014-2016
The present study examined auditory cortical neurons, the responses of which depended on duration noise bursts. We recorded from 150 neurons with response latencies exceeding 30 msec and 28 OFF to stimuli in dorsal zone cat cortex. Of long-latency 132 displayed some form selectivity. Seventy-eight were classified as selective for long durations. Among long-duration-selective responded only burst durations longer than a minimal threshold further neurons. duration-selective 41 selectively...
Tonotopic maps, obtained from single and multi-unit recordings in the primary surrounding areas of auditory cortex, were related to chemoarchitecture supratemporal plane, as delineated by immunoreactivity for parvalbumin. Neurons central core sharply tuned formed two complete tonotopic representations corresponding area (AI) rostral (R) area. High frequencies represented posteriorly AI anteriorly R, representation reversing anterior part core. regions less dense immunostaining previously...
Recent advances in upconversion technology have enabled optogenetic neural stimulation using remotely applied optical signals, but limited success has been demonstrated for inhibition by this method, primarily due to the much higher power and more red-shifted excitation spectrum that are required work with appropriate inhibitory opsin proteins. To overcome these limitations, core-shell-shell nanoparticles (UCNPs) a hexagonal phase synthesized optimize doping contents of ytterbium ions (Yb3+)...
Significance The hippocampus with its dense reciprocal axonal projections to and from cortex is widely believed mediate numerous cognitive functions. However, it unknown whether how specific hippocampal–cortical activity contributes the brain-wide functional connectivity. Here, we use optogenetics fMRI examine excitatory neural initiated in dorsal dentate gyrus of propagates modulates resting-state (rsfMRI) We discover robust propagation at low frequency (1 Hz), which enhances...
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate activity enhance healing remains unexploited. Here it is shown that electrical stimulation (ES) directly promotes biosynthesis and release calcitonin gene-related peptide (CGRP) by activating Ca2+ /CaMKII/CREB signaling pathway action potential, respectively. To accelerate rat femoral osteoporotic which presents with decline CGRP, soft electrodes are engineered they...
Cholecystokinin (CCK) enables excitatory circuit long-term potentiation (LTP). Here, we investigated its involvement in the enhancement of inhibitory synapses. Activation GABA neurons suppressed neuronal responses neocortex to a forthcoming auditory stimulus mice both sexes. High-frequency laser stimulation (HFLS) GABAergic potentiated this suppression. HFLS CCK interneurons could induce LTP their inhibition toward pyramidal neurons. This was abolished knock-out but intact with CCK1R and 2R...
Optical modulation of nervous system becomes increasingly popular as the wide adoption optogenetics. For these applications, upconversion materials hold great promise novel photonic elements. This study describes an based strategy for combinatorial neural stimulation both in vitro and vivo by using spectrum-selective nanoparticles (UCNPs). NaYF4 UCNPs are used to absorb near-infrared (NIR) energy emit visible light stimulating neurons expressing different channelrhodopsin (ChR) proteins. The...
Significance Neuropeptides represent the most diverse family of neurotransmitters with a wide distribution in rodent brain. Cholecystokinin (CCK) is an octapeptide present very high concentrations cortex, where it expressed several circuits. It has emerged as useful marker, for example interneuron subpopulation, but its function still unclear. Here we show that CCK, via CCKB receptor, essential high-frequency stimulation-induced long-term potentiation, and release CCK controlled by NMDA...
Major depressive disorder is a severe psychiatric that afflicts ~17% of the world population. Neuroimaging investigations depressed patients have consistently reported dysfunction basolateral amygdala in pathophysiology depression. However, how BLA and related circuits are implicated pathogenesis depression poorly understood.
The entorhinal cortex is involved in establishing enduring visuo-auditory associative memory the neocortex. Here we explored mechanisms underlying this synaptic plasticity related to projections from visual and cortices auditory mice using optogenetics of dual pathways. High-frequency laser stimulation (HFS laser) projection did not induce long-term potentiation. However, after pairing with sound stimulus, inputs were potentiated following either infusion cholecystokinin (CCK) or HFS...
Abstract The crucial role of interferon (IFN) signaling is well known in the restriction or eradication pathogen invasion. Viruses take a variety ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades. However, way by viruses target extracellularly has not been discovered. Infection both coronavirus SARS-CoV-2 and enterovirus 71 (EV71 EV-A71) can cause severe diseases such as neurological disorders even death children. 1–3 Here, we show evidence that...
High-frequency stimulation (HFS)-induced long-term potentiation (LTP) is generally regarded as a homosynaptic Hebbian-type LTP, where synaptic changes are thought to occur at the synapses that project from site and terminate onto neurons recording site. In this study, we first investigated HFS-induced LTP on urethane-anesthetized rats found cortical HFS enhances neural responses through strengthening of local connectivity with nearby site, rather than This enhanced leads increased output...
It has been well established that Cornu Ammonis-(CA1) and subiculum (SUB) serve as the major output components of entorhinal-hippocampal circuitry. Nevertheless, how neuromodulators regulate neurocircuitry in hippocampal formation remained elusive. Cholecystokinin (CCK), is most abundant neuropeptide central nervous system, which broadly regulates animal's physiological status at multiple levels, including neuroplasticity its behavioral consequences. Here, we uncover exogenous CCK...
Clinical and preclinical studies have consistently demonstrated a correlation between hyperactivity of the amygdala onset depression. However, underlying mechanisms influencing serotonin levels critical neurotransmitter implicated in depression primary target for selective reuptake inhibitors (SSRIs) remain inadequately understood. In this study, we employed restrained inescapable shock (RIS) model to investigate these mice. The RIS paradigm elicited depressive-like phenotypes, increased...
ON and OFF auditory responses were examined on the medial geniculate body (MGB) of guinea pig. Single-unit multiunit recordings performed 13 anesthetized subjects while either noise-burst or pure-tone stimuli applied to ear contralateral recorded hemisphere. Of 2187 uneven-spaced samples, 1142 neurons, 386 488 ON-OFF neurons. Neither nor neurons changed their response patterns when stimulus was from a noise burst 60 dB sound pressure level intensity (expressed in decibels per 20 mPa) pure...
He, Jufang. Modulatory effects of regional cortical activation on the onset responses cat medial geniculate neurons. J. Neurophysiol. 77: 896–908, 1997. Corticofugal modulation activity body (MGB) was examined by locally activating primary auditory cortex (AI) and looking for MGB neurons to acoustic stimuli. Of 103 recorded from 13 hemispheres 11 animals, 91 (88%) showed either a facilitatory or inhibitory effect both; these neurons, 72 25 effects. The average large, with mean increase...
on and off auditory responses were examined in the medial geniculate body (MGB) of guinea pig. Single- multiunit recordings carried out 12 anesthetized animals, noise-burst or pure-tone stimuli applied to ear contralateral recording hemisphere. One hundred thirty-fiveoff on-off neurons 160 onneurons studied, tuning curves 21 oroff from various nuclei MGB. The mean minimum threshold (40.8 ± 20.0 dB SPL, SD; range: 0–80 SPL) was significantly higher than that (28.5 17.6 0–60 SPL; n = 17, P...
In the present study, we investigated auditory responses of medial geniculate (MGB) neurons, through in vivo intracellular recordings anesthetized guinea pigs, while cortex was electrically activated. Of 63 neurons that received corticofugal modulation membrane potential, 30 potentiation and 33 hyperpolarization. The potential (amplitude, mean ± SD, 8.6 5.5 mV; duration, 125.5 75.4 msec) facilitated spontaneous firing MGB neurons. hyperpolarization –11.3 4.9 mV amplitude 210.0 210.1 msec...