A5065536004- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- CRISPR and Genetic Engineering
- Aquaculture disease management and microbiota
- Coccidia and coccidiosis research
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Crystallization and Solubility Studies
- Parasitic Infections and Diagnostics
- MicroRNA in disease regulation
- Renal and related cancers
- Mesenchymal stem cell research
- Helminth infection and control
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Hematopoietic Stem Cell Transplantation
- Genomics and Phylogenetic Studies
- Aquaculture Nutrition and Growth
- Plant nutrient uptake and metabolism
- Plant-Microbe Interactions and Immunity
- Neonatal Respiratory Health Research
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
Wuhan Institute of Technology
2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Shanghai Veterinary Research Institute
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Northwest A&F University
2023-2024
Wuhan Ship Development & Design Institute
2024
Second Affiliated Hospital of Zhengzhou University
2019-2024
Chinese Academy of Sciences
2012-2023
First Institute of Oceanography
2021-2023
Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, are evolutionarily conserved play critical roles in development cancer. However, their cell fate decisions early embryonic remain poorly understood. Here we report knockout of polycomb genes human stem cells causes pluripotency loss spontaneous differentiation toward a meso-endoderm fate, owing to de-repression BMP signalling. Moreover, with deletion EZH1 or EZH2 fail differentiate into ectoderm lineages. We...
Neurogenesis, a highly orchestrated process, entails the transition from pluripotent to neural state and involves progenitor cells (NPCs) neuronal/glial subtypes. However, precise epigenetic mechanisms underlying fate decision remain poorly understood. Here, we delete KDM6s (JMJD3 and/or UTX), H3K27me3 demethylases, in human embryonic stem (hESCs) show that their deletion does not impede NPC generation hESCs. KDM6-deficient NPCs exhibit poor proliferation failure differentiate into neurons...
Human pluripotent stem cells (hPSCs) exhibit very limited contribution to interspecies chimeras. One explanation is that the conventional hPSCs are in a primed state and so unable form chimeras pre-implantation embryos. Here, we show undergo rapid apoptosis when injected into mouse While, forced-expression of BMI1, polycomb factor overcomes enables integrate embryos subsequently contribute with both embryonic extra-embryonic tissues. In addition, BMI1 also other species, such as rabbit pig....
With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for proliferation differentiation. These changes may contribute to the development of neurodegenerative diseases such as Alzheimer’s disease (AD) Parkinson’s (PD). In these conditions, disease-specific pathological interact with alterations NSCs, resulting in impairment...
Neomycin, an aminoglycoside antibiotic, is widely utilized for veterinary medicine in disease prevention. Biodegradation a key pathway the removal of neomycin from environment. To date, only white-rot fungus Trametes versicolor and ericoid mycorrhizal Rhizoscyphus ericae have been documented to efficiently degrade neomycin. However, no bacterial species with neomycin-degrading capabilities reported, underscoring significant gap microbial research related remediation. In this study,...
This study aimed to evaluate the effects of frequency-specific music stimulation on awareness and brain connectivity in patients with disorders consciousness (DOC). A total 25 DOC were exposed auditory through at varying frequencies (low: <0.5 Hz, middle: 0.5 Hz-3.5 kHz, high: >3.5 kHz). Brain responses assessed using Functional Near-Infrared Spectroscopy (fNIRS) monitor objective markers activity. The analysis focused effective coupling strength (CS) values response different frequency...
The groundbreaking discovery of induced pluripotent stem cells (iPS cells) provides a new source for cell therapy. However, whether the iPS derived functional lineages from different origins have immunogenicity remains unknown. It had been known that isolated extra-embryonic tissues, such as umbilical cord mesenchymal (UMCs), are less immunogenic than other adult skin fibroblasts (SFs). In this report, we differentiated human UMCs and SFs into neural progenitor (NPCs) analyzed their...
Eimeria tenella, an intestinal parasite, has brought huge economic losses to the poultry industry. The prevalence and severity of development drug resistance increased challenge coccidiosis control. We previously identified enolase 2 E. tenella (EtENO2) was differentially expressed in drug-sensitive (DS) drug-resistant strains using RNA-seq. In this study, expression EtENO2 diclazuril-resistant (DZR), maduramicin-resistant (MRR), salinomycin-resistant (SMR) analyzed by quantitative real-time...
Human neural progenitor cell (hNPC) transplantation holds great potential to treat neurological diseases. However, hNPC grafts take a long time differentiate into mature neurons due their intrinsically prolonged developmental timetable. Here, we report that postoperative physical exercise (PE), prevailing rehabilitation intervention, promotes the neuronal commitment, maturation, and integration of engrafted hNPCs, evidenced by forming more synapses, receiving synaptic input from host...
Abstract Human urine cells (HUCs) can be reprogrammed into neural progenitor (NPCs) or induced pluripotent stem (iPSCs) with defined factors and a small molecule cocktail, but the underlying fate choice remains unresolved. Here, through sequential removal of individual compound from we showed that A8301, TGFβ signaling inhibitor, is sufficient to switch cell iPSCs NPCs in OSKM-mediated HUCs reprogramming. However, exposure at early stage inhibits reprogramming by promoting EMT. Base on these...
The breakthrough development of induced pluripotent stem cells (iPSCs) raises the prospect patient-specific treatment for many diseases through replacement affected cells. However, whether iPSC-derived functional cell lineages generate a deleterious immune response upon auto-transplantation remains unclear. In this study, we differentiated five human iPSC lines from skin fibroblasts and urine into neural progenitor (NPCs) analyzed their immunogenicity. Through co-culture with autogenous...
Soil nutrient availability under saline-alkali stress limits plant primary productivity. P-solubilizing bacteria (PSB) improve inorganic P dissolution and promote growth. However, the application studies of saline-alkaline-tolerant PSB are still scarce. We isolated one strain from bird droppings in regions identified its growth characteristics resistance to salt alkali. A potting experiment with addition was performed analyze effect this on germination Suaeda salsa. The were as...
Abstract High total P content but insufficient available in soil is an obstacle that restricts the efficient utilization of saline–alkali regions. Although resistant P-solubilizing bacteria (PSB) solubilize insoluble P, few studies have focused on their application plant growth. We isolated a PSB strain, identified as Bacillus sp. DYS211, from bird droppings regions and determined its growth characteristics resistance to salt alkalis. To investigate effect germination seeds, we performed...