A5031183708- Organic Electronics and Photovoltaics
- Pluripotent Stem Cells Research
- Nanomaterials for catalytic reactions
- Conducting polymers and applications
- Adsorption and biosorption for pollutant removal
- Luminescence and Fluorescent Materials
- Organic Light-Emitting Diodes Research
- Ferroptosis and cancer prognosis
- Supercapacitor Materials and Fabrication
- Mitochondrial Function and Pathology
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Magnetic Properties and Synthesis of Ferrites
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Iron oxide chemistry and applications
- Organoboron and organosilicon chemistry
- Advancements in Battery Materials
- Graphene research and applications
- Synthesis and properties of polymers
- Copper-based nanomaterials and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Silicone and Siloxane Chemistry
- X-ray Diffraction in Crystallography
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
Southwest Medical University
2020-2025
Affiliated Hospital of Southwest Medical University
2024
Lanzhou University
2024
Harbin University of Science and Technology
2024
Central China Normal University
1999-2022
Guangzhou Institutes of Biomedicine and Health
2013-2021
University of Chinese Academy of Sciences
2021
Chinese Academy of Sciences
2013-2020
Guangzhou Medical University
2017
University of Hong Kong
2017
Glioblastoma, the most aggressive form of malignant glioma, is very difficult to treat because its aggressively invasive nature and high recurrence rates. RAS-selective lethal 3 (RSL3), a well-known inhibitor glutathione peroxidase 4 (GPX4), could effectively induce oxidative cell death in glioblastoma cells through ferroptosis, several signaling pathways are involved this process. However, role nuclear factor kappa-B (NF-κB) pathway ferroptosis has not yet been investigated. Therefore, we...
Abstract Reprogramming has been shown to involve EMT–MET; however, its role in cell differentiation is unclear. We report here that vitro of hESCs hepatic lineage undergoes a sequential EMT–MET with an obligatory intermediate mesenchymal phase. Gene expression analysis reveals Activin A-induced formation definitive endoderm (DE) accompanies synchronous EMT mediated by autocrine TGFβ signalling followed MET process. Pharmacological inhibition blocks the as well DE formation. then identify...
Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, are evolutionarily conserved play critical roles in development cancer. However, their cell fate decisions early embryonic remain poorly understood. Here we report knockout of polycomb genes human stem cells causes pluripotency loss spontaneous differentiation toward a meso-endoderm fate, owing to de-repression BMP signalling. Moreover, with deletion EZH1 or EZH2 fail differentiate into ectoderm lineages. We...
Valproic acid (VPA) is widely used to treat epilepsy, migraine, chronic headache, bipolar disorder, and as adjuvant chemotherapy, but potentially causes idiosyncratic liver injury. Alpers‐Huttenlocher syndrome (AHS), a neurometabolic disorder caused by mutations in mitochondrial DNA polymerase gamma (POLG), associated with an increased risk of developing fatal VPA hepatotoxicity. However, the mechanistic link this clinical mystery remains unknown. Here, fibroblasts from 2 AHS patients were...
Abstract Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority DGUOK mutant MDS patients develop iron overload progressing to liver failure. However, the pathological mechanisms connecting and hepatic damage remains uncovered. Here, two patients’ skin fibroblasts are reprogrammed induced pluripotent stem cells (iPSCs) then corrected CRISPR/Cas9. Patient‐specific iPSCs...
Two efficient blue-light-emitting materials with stable diarylfluorene and hole-transporting pyrene groups, 9-alkoxyphenyl-9-pyrenylfluorene substituted pyrenes (EHOP1 EHOP2), have been synthesized by Suzuki coupling reaction fully characterized. They extreme thermal stability in nitrogen onset decomposition temperature over 430 °C. are amorphous Tg of 103 191 °C for EHOP1 EHOP2, respectively. show bright blue emission the solid state. Due to non-conjugated groups at C9 fluorene moieties,...
The groundbreaking discovery of induced pluripotent stem cells (iPS cells) provides a new source for cell therapy. However, whether the iPS derived functional lineages from different origins have immunogenicity remains unknown. It had been known that isolated extra-embryonic tissues, such as umbilical cord mesenchymal (UMCs), are less immunogenic than other adult skin fibroblasts (SFs). In this report, we differentiated human UMCs and SFs into neural progenitor (NPCs) analyzed their...
A series of n-type fulleropyrrolidine derivatives as the acceptors, including Th-C60, PFTh-C60, and OPFTh-C60, have been synthesized via key step typical Prato reaction to investigate steric hindrance effect various phenylfluorenyl moieties on electronic structures, aggregate morphologies, device performances solar cells. Conjugation-interrupted linkage obviously does not change energy bandgaps lowest unoccupied molecular orbital (LUMO) levels in PFTh-C60 OPFTh-C60 models with respect that...
By means of the limited conjugation length, intrinsic 3-dimensional conformations and potential nanoporous structures, π-conjugation-interrupted hyperbranched polymers (CIHPs) were demonstrated as polymer electrets for application organic transistor memory devices.
To suppress concentration quenching and to improve charge-carrier injection/transport in the emission layer (EML) of phosphorescent organic light-emitting diodes (PhOLEDs), a facial homoleptic iridium(III) complex emitter with amorphous characteristics was designed prepared one step from multifunctional spiro ligand containing spiro[fluorene-9,9'-xanthene] (SFX) unit. Single-crystal X-ray analysis resulting fac-Ir(SFXpy)3 revealed an enlarged Ir···Ir distance negligible intermolecular π-π...
Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during biogenesis and ciliogenesis. highly dynamic cell cycle or ciliogenesis how they regulated remains largely unknown. We report here sorting nexin 17 (SNX17) regulates the homeostasis of a subset centriolar satellite including PCM1, CEP131, OFD1 serum-starvation-induced Mechanistically, SNX17 recruits deubiquitinating enzyme USP9X antagonize mindbomb 1 (MIB1)-induced ubiquitination degradation...
Diazafluorene (DAF) has a similar configuration to fluorene unit except that two carbon atoms are replaced with nitrogen atoms, offering an ideal model of supramolecular conjugated polymers investigate the structure–property relationship. Herein, series DAF-based oligofluorenes and polyfluorenes, including NFF, NF2F, F2NF, PFO-NO, PFO-N5, PFO-N15 PFO-N50, have been synthesized by Suzuki and/or Yamamoto polymerization. All dioctyldiazafluorene-based copolymers show improved solubility, high...
Abstract The controlled/living radical polymerization of 2‐( N ‐carbazolyl)ethyl methacrylate (CzEMA) and 4‐(5‐(4‐ tert ‐butylphenyl‐1,3,4‐oxadiazol‐2‐yl)phenyl) ( t ‐Bu‐OxaMA) via reversible addition‐fragmentation chain transfer has been studied. Functional polymers with hole‐ or electron‐transfer ability were synthesized cumyl dithiobenzoate as a agent (CTA) AIBN an initiator in benzene solution. Good control the was confirmed by linear increase molecular weight (MW) conversion. dependence...