A5102783585- Microbial Metabolism and Applications
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
Southwest Medical University
2021
Glioblastoma, the most aggressive form of malignant glioma, is very difficult to treat because its aggressively invasive nature and high recurrence rates. RAS-selective lethal 3 (RSL3), a well-known inhibitor glutathione peroxidase 4 (GPX4), could effectively induce oxidative cell death in glioblastoma cells through ferroptosis, several signaling pathways are involved this process. However, role nuclear factor kappa-B (NF-κB) pathway ferroptosis has not yet been investigated. Therefore, we...
Objective. This study used in vitro techniques to investigate the therapeutic effect of Radix Salviae on human glioblastoma and decode its underlying molecular mechanism. Methods. The active components targets were identified from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). obtained GeneCards Database. Salviae-mediated antiglioblastoma was evaluated by Gene Ontology (GO) analyses Kyoto Encyclopedia Genes Genomes pathway enrichment analyses. Finally, mechanism action...