A5100737330- Neuroinflammation and Neurodegeneration Mechanisms
- Cervical and Thoracic Myelopathy
- Traditional Chinese Medicine Analysis
- Cancer Cells and Metastasis
- Neurological Disease Mechanisms and Treatments
- Digital Imaging for Blood Diseases
- Stress Responses and Cortisol
- COVID-19 diagnosis using AI
- Cancer-related gene regulation
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Spinal Hematomas and Complications
- Neurological Disorders and Treatments
- AI in cancer detection
- Energy Harvesting in Wireless Networks
- Metastasis and carcinoma case studies
- Neurogenetic and Muscular Disorders Research
- Radiomics and Machine Learning in Medical Imaging
- Reproductive System and Pregnancy
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Antenna Design and Analysis
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Sinusitis and nasal conditions
Chongqing Medical University
2017-2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Hunan University of Technology
2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2021
Southwest Medical University
2006-2021
Qingdao University
2013-2014
Affiliated Hospital of Qingdao University
2013-2014
New York University Langone Orthopedic Hospital
2011
First Affiliated Hospital of Sichuan Medical University
2006
The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis (TNFRs) disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible collagen-induced arthritis, administration of reversed inflammatory arthritis. Atsttrin, an engineered protein composed three fragments, exhibited selective TNFR binding. Atsttrin prevented...
SOX4 is highly expressed in gastric cancer (GC) and associated with tumor grade, metastasis prognosis, however the mechanism not clear. We report herein that was upregulated overexpression of increased expression markers Epithelial–mesenchymal transition (EMT) stemness clinic patient samples. In vitro, promoted invasion as showed by Transwell assay GC cells assessed sphere formation assay, which suppressed silencing shRNA. Further studies up-regulated EMT transcription factors Twist1, snail1...
COVID-19 has caused enormous challenges to global economy and public health. The identification of patients with the infection by CT scan images helps prevent its pandemic. Manual screening COVID-19-related spends a lot time resources. Artificial intelligence techniques including deep learning can effectively aid doctors medical workers screen patients. In this study, we developed an ensemble framework, DeepDSR, combining DenseNet, Swin transformer, RegNet for image identification. First,...
Since the outbreak of COVID-19, hundreds millions people have been infected, causing deaths, and resulting in a heavy impact on daily life countless people. Accurately identifying patients taking timely isolation measures are necessary ways to stop spread COVID-19. Besides nucleic acid test, lung CT image detection is also path quickly identify COVID-19 patients. In this context, deep learning technology can help radiologists from images rapidly. paper, we propose ensemble framework called...
Human leukocyte antigen-G (HLA-G) plays an important role in inhibiting natural killer (NK) cell function and promoting immune escape. However, the specific mechanism of HLA-G on NK gastric cancer (GC) remains not well understood. This study investigated expression GC HLA-G-effected cells progression.HLA-G tissues obtained from 49 patients with was analyzed by immunohistochemistry western blot. The number tumor-infiltrating their surface receptors were flow cytometry, respectively. effect...
Astragalus is a widely used traditional Chinese medicine and has been proven beneficial for many aspects of human health. It important to explore the neuroprotective effect mechanism astragalus injection in cerebral ischemia reperfusion injury.The focal ischemic model with middle artery occlusion (MCAO) was established by Longa's method healthy adult male Wistar rats, treated injecting intraperitoneally (3 ml/kg). The neurobehavioral function rats evaluated test. blood flow (CBF) measured...
Abstract Background Management of anterior cervical corpectomy and fusion (ACCF)-derived adjacent segment disease (ASD) represented a challenge facing the surgeons. Methods A 41-year man diagnosed as C3-4 level ASD derived from C5-level ACCF surgery 13 years ago was admitted to hospital for numbness pain in right shoulder upper limb. Percutaneous full-endoscopic transcorporeal discectomy (PEATCD) performed, pre- postoperative clinical imaging data were collected. Results The operation...
Picroside II could reduce the oxidative damage induced by cerebral ischemia-reperfusion and improve nerve behavior function of rats.The aim this study was to optimize therapeutic dose time window picrosede orthogonal test in ischemic injury forebrain ischemia models were established bilateral common carotid artery occlusion (BCCAO) methods.The successful randomly grouped according experimental design treated injecting picroside intraperitonenally at different with dose.The concentration...
Objective. This study used in vitro techniques to investigate the therapeutic effect of Radix Salviae on human glioblastoma and decode its underlying molecular mechanism. Methods. The active components targets were identified from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). obtained GeneCards Database. Salviae-mediated antiglioblastoma was evaluated by Gene Ontology (GO) analyses Kyoto Encyclopedia Genes Genomes pathway enrichment analyses. Finally, mechanism action...
Abstract Background: Management of anterior cervical corpectomy and fusion (ACCF)-derived adjacent segment disease (ASD) represented a challenge facing the surgeons. Methods: A 41-year man diagnosed as C3-4 level ASD derived from C5-level ACCF surgery 13 years ago was admitted to hospital for numbness pain in right shoulder upper limb. Percutaneous full-endoscopic transcorporeal discectomy (PEATCD) performed, pre- postoperative clinical imaging data were collected. Results: The operation...