A5059680203- GaN-based semiconductor devices and materials
- ZnO doping and properties
- Ga2O3 and related materials
- Protein Interaction Studies and Fluorescence Analysis
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Analytical Chemistry and Chromatography
- Semiconductor Quantum Structures and Devices
- Drug Transport and Resistance Mechanisms
- Heavy metals in environment
- Water Quality and Pollution Assessment
- Geochemistry and Geologic Mapping
- Surfactants and Colloidal Systems
- Photoreceptor and optogenetics research
- Nanowire Synthesis and Applications
- Advanced Photocatalysis Techniques
- Receptor Mechanisms and Signaling
- Plasma Diagnostics and Applications
- solar cell performance optimization
- COVID-19 Clinical Research Studies
- Food Allergy and Anaphylaxis Research
- Efficiency Analysis Using DEA
- Phytochemistry and Biological Activities
- Molecular spectroscopy and chirality
- Open Source Software Innovations
City University of Hong Kong
2022-2025
Chinese Academy of Sciences
2023-2024
Shenzhen University
2014-2023
China Medical University
2023
UCSF Helen Diller Family Comprehensive Cancer Center
2021
University of California, San Francisco
2021
Epistar (Taiwan)
2018
National Cheng Kung University
2010-2018
National Defense University
2015
Harvard University
2005
Hereditary hemochromatosis is an iron-overload disorder resulting from mutations in proteins presumed to be involved the maintenance of iron homeostasis. Mutations hemojuvelin (HJV) cause severe, early-onset juvenile hemochromatosis. The normal function HJV unknown. Juvenile patients have decreased urinary levels hepcidin, a peptide hormone that binds cellular exporter ferroportin, causing its internalization and degradation. We disrupted murine Hjv gene shown Hjv–/– mice markedly increased...
It has been well established that Cornu Ammonis-(CA1) and subiculum (SUB) serve as the major output components of entorhinal-hippocampal circuitry. Nevertheless, how neuromodulators regulate neurocircuitry in hippocampal formation remained elusive. Cholecystokinin (CCK), is most abundant neuropeptide central nervous system, which broadly regulates animal's physiological status at multiple levels, including neuroplasticity its behavioral consequences. Here, we uncover exogenous CCK...
The hippocampus is broadly impacted by neuromodulations. However, how neuropeptides shape the function of and related spatial learning memory remains unclear. Here, we discover crucial role cholecystokinin (CCK) in heterosynaptic neuromodulation from medial entorhinal cortex (MEC) to hippocampus. Systematic knockout CCK gene impairs CA3-CA1 LTP space-related performance. MEC provides most CCK-positive neurons projecting hippocampal region, which potentiates long-term plasticity...
In this study, gallium nitride (GaN)-based metal-insulator-semiconductor (MIS) ultraviolet (UV) photodetectors (PDs) with a oxide (GaO(x)) gate layer formed by alternating current bias-assisted photoelectrochemical oxidation of n-GaN are presented. By introducing the GaO(x) to GaN MIS UV PDs, leakage is reduced and much larger UV-to-visible rejection ratio (R(UV/vis)) spectral responsivity achieved. addition, bias-dependent response results in marked increase R(UV/vis) bias voltage up...
Long-term potentiation (LTP), which underlies learning and memory, can be induced by high-frequency electrical stimulation (HFS or HFES) is thought to occur at the synapses of efferent projection. Here, contralateral connectivity in mice auditory cortex was investigated reveal fundamental corticocortical connection properties. After HFES, plasticity not observed terminal recording site. The optogenetic HFS site interhemispheric cortical projections could induce LTP, but HFES LTP. Our...
Cholecystokinin (CCK) is the most abundant neuropeptide that broadly regulates physiological status of animals. Here, we present a two-color laser theta burst stimulation (L-TBS) protocol for simultaneous activation Schaffer collateral and perforant pathway in hippocampus CCK Cre mice. We describe steps heterosynaptic long-term potentiation induction by L-TBS. This technique allows examination neurotransmitter roles synaptic modulation facilitates exploration pathological mechanisms genetic...
Subiculum is a pivotal output component of the hippocampal formation, structure often overlooked in neuroscientific research. Here, this review aims to explore role subiculum various brain disorders, shedding light on its significance within functional-neuroanatomical perspective neurological diseases. The subiculum's involvement multiple disorders was thoroughly examined. In Alzheimer's disease, alterations precede cognitive decline, while epilepsy, plays critical seizure initiation. Stress...
InGaN/sapphire-based p-i-n type photovoltaic (PV) devices were shown to have Al0.14Ga0.86N/In0.21Ga0.79N heterostructures that enhance the extraction of photogenerated carriers from active layers. With an appropriately increased barrier height in AlGaN/InGaN absorption layers, PV exhibit lower RS despite increase conduction-band discontinuity compared with GaN/InGaN superlattice This improvement can be attributed polarization-induced electric fields enhanced by incorporated aluminum The...
Abstract Globally, tuberculosis is a leading cause of infectious disease deaths. China ranks third among the 30 high‐burden countries for and accounts approximately 7.4% cases reported worldwide. Since very few studies have investigated age difference in prevalence mainland China, therefore, preliminary characterisation differences patients not well understood. The data sputum smear‐positive, smear‐negative 340 prefectures from were extracted Information System Disease Control Prevention...
The effect of Mn concentration on the optical properties Mn-doped layers grown by metalorganic vapor phase epitaxy is investigated. GaN exhibite a typical transmittance spectrum with distinct dip around 820 nm which attributed to transition electrons between edge valence band and Mn-related states within bandgap. In addition, electroluminescence (EL) spectra obtained from bipolar devices active layer also show that considerable energy existed in position first evaluated via EL spectra....
It is usually believed that surface plasmon (SP) coupling practically useful only for improving the performance of a light-emitting diode (LED) with low intrinsic internal quantum efficiency (IQE). In this Letter, we demonstrate commercial-quality blue LED high IQE (>80%) can still be significantly improved through SP based on Ag nanoparticle (NP) structure. The improvement such an achieved by increasing Mg doping concentration in its p-AlGaN electron blocking layer to enhance hole injection...
Kusaginin, as a phenylethanoid glycoside, which has exhibited wide antioxidant and antimicrobial properties. The molecular mechanism underlying the broad biological activities of kusaginin not yet been well documented. In this paper, interaction with bovine serum albumin (BSA) explored by fluorescence spectra, UV-vis absorption circular dichroism (CD) spectra along computational approaches. experiments showed that could strongly quench intrinsic BSA through both dynamic static quenching...
GaN-based solar cells with Mn-doped absorption layer grown by metal-organic vapor-phase epitaxy were investigated. The transmittance spectrum and the spectral response showed presence of an Mn-related band property. Power-dependent, dual-light excitation, lock-in amplifier techniques performed to confirm if two-photon process occurred in GaN layer. Although a slight decrease open circuit voltage was observed, prominent increase short current density resulted significant enhancement overall...
Hydrogen generation through direct photoelectrolysis of water was studied using photoelectrochemical (PEC) cells made Mn-doped GaN photoelectrodes. In addition to its absorption the ultraviolet spectrum, photoelectrodes could absorb photons in visible spectrum. The photocurrents measured from PEC were at least one order higher than those undoped GaN-working electrodes. Under light illumination and a bias voltage below 1.2 V, drive splitting reaction for hydrogen generation. However, not be...
Circular dichroism spectra, fluorescence synchronous resonance light scattering ELISA experiments, along with bioinformatics method have been used to study the relationship between immunogenicity and structure of recombinant peanut protein Ara h 2.01 increase in temperature. The experimental results show that collapses gradually within temperature range from room 100 °C, collapse reaches saturation at around while its secondary structures remain almost same, decreases steadily over range....
The interaction of trypsin with acteoside was studied using ultraviolet visible absorption, fluorescence, synchronous circular dichroism techniques, along molecular docking method. fluorescence experiments indicated that quenched the intrinsic via a combined quenching process (static and dynamic quenching). binding constant to obtained 2.50 × 105 L mol−1 at 298 K number site about one under same experimental condition. thermodynamic functions ΔH° ΔS° were 8.79 kJ 132.58 J K−1, respectively,...
InGaN/sapphire-based photovoltaic (PV) cells with blue-band GaN/InGaN multiple-quantum-well absorption layers grown on patterned sapphire substrates were characterized under high concentrations up to 150-sun AM1.5G testing conditions. When the concentration ratio increased from 1 150 suns, open-circuit voltage of PV 2.28 2.50 V. The peak power conversion efficiency (PCE) occurred at 100-sun conditions, where maintained fill factor as 0.70 and exhibited a PCE 2.23%. results showed great...
The interaction of acteoside with pepsin has been investigated using fluorescence spectra, UV/vis absorption three-dimensional (3D) spectra and synchronous along a molecular docking method. experiments indicate that can quench the intrinsic through combined quenching at low concentration acteoside, static high concentrations. Thermodynamic analysis suggests hydrogen bonds van der Waal's forces are main between acteoside. According to theory Förster's non-radiation energy transfer, binding...