A5007707787- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Protein Interaction Studies and Fluorescence Analysis
- Marine animal studies overview
- Coal and Its By-products
- Machine Learning in Healthcare
- RNA modifications and cancer
- Hepatitis C virus research
- Recycling and utilization of industrial and municipal waste in materials production
- Cancer-related gene regulation
- COVID-19 and Mental Health
- Coagulation and Flocculation Studies
- Aquaculture disease management and microbiota
- Biosensors and Analytical Detection
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Inflammatory Biomarkers in Disease Prognosis
- Waste Management and Recycling
- Cardiomyopathy and Myosin Studies
- Chromosomal and Genetic Variations
Wenzhou Medical University
2019-2024
Central South University
2024
Xiangya Hospital Central South University
2024
Zhejiang Chinese Medical University
2024
Jinan University
2023
Nanjing Normal University
2001-2022
Center for Disease Control
2005-2022
Xuzhou Medical College
2016-2020
Chinese Academy of Fishery Sciences
2020
Zhejiang Taizhou Hospital
2019
Severity prediction of COVID-19 remains one the major clinical challenges for ongoing pandemic. Here, we have recruited a 144 patient cohort, resulting in data matrix containing 3,065 readings 124 types measurements over 52 days. A machine learning model was established to predict disease progression based on cohort consisting training, validation, and internal test sets. panel eleven routine factors constructed classifier severity prediction, achieving accuracy 98% discovery set. Validation...
Securely computing graph convolutional networks (GCNs) is critical for applying their analytical capabilities to privacy-sensitive data like social/credit networks. Multiplying a sparse yet large adjacency matrix of in GCN--a core operation training/inference--poses performance bottleneck secure GCNs. Consider GCN with $|V|$ nodes and $|E|$ edges; it incurs $O(|V|^2)$ communication overhead. Modeling bipartite graphs leveraging the monotonicity non-zero entry locations, we propose co-design...
RT-PCR is the primary method to diagnose COVID-19 and also used monitor disease course. This approach, however, suffers from false negatives due RNA instability poses a high risk medical practitioners. Here, we investigated potential of using serum proteomics predict viral nucleic acid positivity during COVID-19. We analyzed proteome 275 inactivated samples 54 out 144 patients shortlisted 42 regulated proteins in severe group 12 non-severe group. Using these several key clinical indexes,...
Interleukin-7 receptor (IL-7R) is involved in the abnormal function of solid tumors, but role and regulatory mechanisms IL-7R HBV-related hepatocellular carcinoma (HCC) are still unclear.Gene protein expression levels were examined hepatoma cells transfected with hepatitis B virus (HBV) plasmids multifunctional nonstructural X (HBX). The HBX was measured by immunohistochemical analysis HCC tissues. NF-κB Notch1 pathways HBX-mediated examined. Activation downstream intracellular signaling...
Abstract Objectives Interleukin‐34 (IL‐34) is associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). However, the role mechanisms of IL‐34 in HBV‐related HCC remain unclear. In this study, expression, biological function cells were investigated. Methods expression induced by HBV X (HBX) gene was measured hepatoma cells. The CCAAT/enhancer‐binding protein α (CEBP/α) HBX‐induced examined. signal pathways involved CEBP/α HBX assessed. proliferation migration...
The major histocompatibility complex (MHC) is a fundamental part of the vertebrate immune system, and high variability in many MHC genes thought to play an important role recognition parasites. Baiji (Lipotes vexillifer) one most endangered species world. Its wild population has declined fewer than 100 individuals very risk becoming extinct near future. In this study we present first step molecular characterization DQB-like locus baiji by nucleotide sequence analysis polymorphic exon 2...
In 2022, a new coronavirus variant (Omicron) infection epidemic broke out in Shanghai, China. However, it is unclear whether the duration of this omicron different from that prototype strain.We retrospectively analyzed 157 cases Omicron Taizhou Public Health Center March 29, to April 18, and observed dynamics nucleic acid Ct values during admission discharge patients. Clinical laboratory indicators these patients were also obtained.Compared strain, showed broad population susceptibility...
Background: Reconstituted lipoproteins (rLips) based on endogenous lipid nanostructures has been increasingly regarded as an excellent and promising antitumor drug delivery. However, some problems relating to the main component, apolipoprotein, for instance, rare source, unaffordable price, low specificity of relevant receptor expression, become chief obstacles its broad development application. Purpose: The primary aim this study is develop biomimetic rLips by utilizing folic acid...
Circular dichroism spectra, fluorescence synchronous resonance light scattering ELISA experiments, along with bioinformatics method have been used to study the relationship between immunogenicity and structure of recombinant peanut protein Ara h 2.01 increase in temperature. The experimental results show that collapses gradually within temperature range from room 100 °C, collapse reaches saturation at around while its secondary structures remain almost same, decreases steadily over range....
Serum antibodies IgM and IgG are elevated during Coronavirus Disease 2019 (COVID-19) to defend against viral attacks. Atypical results such as negative abnormally high antibody expression were frequently observed whereas the underlying molecular mechanisms elusive. In our cohort of 144 COVID-19 patients, 3.5% both negative, 29.2% remained only negative. The remaining patients exhibited positive expression, with 9.3% them exhibiting over 20-fold higher titers than others at their plateau. in...
Information about dynamic changes occurring in the parameters and morphology of erythrocytes platelets during coronavirus disease 2019 (COVID-19) infection convalescence is scarce. To explore potential associations between erythrocyte platelet parameters, morphological changes, course or severity essential.From January 17th, 2020, to February 20th, 2022, we followed up on 35 patients with non-severe 11 severe COVID-19 following their discharge. We collected clinical features, complete blood...
Waning vaccine-induced immunity and emergence of new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants which may lead to immune escape, pose a major threat the COVID-19 pandemic. Currently, enhanced efficacy neutralization antibodies (NAb) produced after booster dose vaccinations against Omicron variant is main focus vaccine strategy research. In this study we have analyzed potency NAbs IgGs third in patients infected with wild-type (WT) SARS-CoV-2.We enrolled 75...
Abnormal placental angiogenesis is an important cause of fetal intrauterine growth restriction (IUGR), but its underlying mechanisms and therapies remain unclear. Adenosine mediated signaling has been reported to be associated with the development angiogenesis. However, whether adenosine-related plays a role in modulating placenta IUGR pregnancy outcomes remains unclear.The adenosine expressions normal placentas were detected different species. And regulating was evaluated using diet-induced...
The interaction of acteoside with pepsin has been investigated using fluorescence spectra, UV/vis absorption three-dimensional (3D) spectra and synchronous along a molecular docking method. experiments indicate that can quench the intrinsic through combined quenching at low concentration acteoside, static high concentrations. Thermodynamic analysis suggests hydrogen bonds van der Waal's forces are main between acteoside. According to theory Förster's non-radiation energy transfer, binding...