A5029937389- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Electrocatalysts for Energy Conversion
- Supramolecular Self-Assembly in Materials
- Global trade and economics
- Supramolecular Chemistry and Complexes
- Computational Drug Discovery Methods
- Economic Policies and Impacts
- Viral gastroenteritis research and epidemiology
- Advanced Photocatalysis Techniques
- COVID-19 epidemiological studies
- Fiscal Policy and Economic Growth
- International Business and FDI
- Mosquito-borne diseases and control
- Gas Sensing Nanomaterials and Sensors
- Neuroscience and Neuropharmacology Research
- Molecular Sensors and Ion Detection
- COVID-19 and healthcare impacts
- Advanced Chemical Sensor Technologies
- Adsorption and biosorption for pollutant removal
- Fuel Cells and Related Materials
- COVID-19 diagnosis using AI
- Environmental remediation with nanomaterials
Guangzhou Medical University
2018-2025
China University of Mining and Technology
2025
University of Hong Kong
2020-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Shenyang Ligong University
2024
Shandong University of Technology
2024
Chinese University of Hong Kong
2024
Queen Mary Hospital
2023
Shanghai University
2021-2023
Wenzhou Medical University
2020-2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted person to and, months, has caused more than 82 000 laboratory-confirmed cases of disease 2019 (COVID-19) and 2800 deaths 46 countries. The total number surpassed that the 2003 severe (SARS-CoV). Although both COVID-19 (SARS) manifest as pneumonia, associated with apparently efficient transmission, fewer diarrhoea, increased mental confusion, a lower...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging that has resulted in more than 000 laboratory-confirmed cases including over 145 deaths. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, appears to be highly efficient person-to-person transmission frequently causes asymptomatic or presymptomatic infections. However, the underlying mechanisms confer these viral characteristics high transmissibility infection...
Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. Dendritic cells macrophages are sentinel for innate adaptive immunity that affect the pathogenesis severe acute syndrome (SARS) Middle East (MERS). The interplay between SARS-CoV-2 these cell types remains unknown. We investigated infection host responses monocyte-derived dendritic (moDCs) (MDMs) infected by...
Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike that has been suggested associate with an increased recognition of mouse ACE2, raising the postulation these variants may have evolved expand species tropism wildtype potentially other murines. Our study evaluated this possibility substantial public health importance.
Abstract Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on transmissibility and pathogenesis, reveal targets intervention. Here, we analyze host viral determinants essential for in both lung epithelial ex vivo tissues. We identify heparan sulfate as an important attachment factor infection. Next, show sialic acids present ACE2 prevent spike/ACE2-interaction. While SARS-CoV is substantially limited by acid-mediated restriction...
SARS-CoV-2 B.1.1.529.1 (Omicron BA.1) emerged in November 2021 and quickly became the predominant circulating variant globally. Omicron BA.1 contains more than 30 mutations spike protein, which contribute to its altered virological features when compared ancestral or previous variants. Recent studies by us others demonstrated that is less dependent on transmembrane serine protease 2 (TMPRSS2), efficient cleavage, fusogenic, adopts an propensity utilize plasma membrane endosomal pathways for...
The hydrogen evolution reaction performance of semiconducting 2H-phase molybdenum disulfide (2H-MoS2) presents a significant hurdle in realizing its full potential applications. Here, we utilize theoretical calculations to predict possible functionalized graphene quantum dots (GQDs), which can enhance HER activity bulk MoS2. Subsequently, design GQD-induced in-situ bottom-up strategy fabricate near atom-layer 2H-MoS2 nanosheets mediated with GQDs (ALQD) by modulating the concentration...
Abstract Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten global public health. Small molecule antivirals are an effective treatment strategy to fight against virus. However, first-generation either show limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of these drugs across globe, they face great pressure drug resistance. We herein present discovery characterization a...
A cross-linked supramolecular polymer network gel was prepared by orthogonal self-assembly of two homoditopic monomers and a metallic cross-linker. The is transparent free-standing, which not only shows an interesting gel–sol transition in response to quadruple-stimuli, but also exhibits self-healing properties, as can be seen the naked eye evidenced rheological characterization. These unique features are all due dynamically reversible host–guest complexation good mechanical properties...
A novel pH-responsive supramolecular polymer based on the pillar[5]arene/imidazolium cation recognition motif was successfully prepared. It demonstrated that binding strength between monomer molecules in solution could be reduced by adding base, thereby leading to a decrease polymerization degree, while reverse switch achieved addition of acid change back cationic state. These processes were confirmed 1H NMR, DOSY experiments, viscosity measurements and theoretical calculations. Moreover,...
Evolutionary arms race dynamics shape the diversity of viruses and their receptors. Identification key residues which are involved in interspecies transmission is important to predict potential pathogen spillover from wildlife humans. Previously, we have identified genetically diverse SARSr-CoVs Chinese horseshoe bats. Here, show highly polymorphic ACE2 bat populations. These variants support SARS-CoV SARSr-CoV infection but with different binding affinities spike proteins. The higher...
Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis pathogenesis coronavirus infections is unknown. Here, with a combination vitro, ex vivo, and vivo models, we demonstrated that protein kinase R-like endoplasmic reticulum (PERK) signaling mediated proapoptotic signals Middle East respiratory syndrome (MERS-CoV) infection, which converged intrinsic pathway. Inhibiting PERK or both alleviated MERS vivo. Severe acute...
High-efficiency electrochemical hydrogen evolution reaction (HER) offers a promising strategy to address energy and environmental crisis. Platinum is the most effective electrocatalyst for HER. However, challenging scarcity, valuableness, poor stability still hinder its wide application. Here, we designed an outstanding HER electrocatalyst, highly dispersed rhodium (Rh) nanoparticles with average diameter of only 3 nm supported on boron (B) nanosheets. The catalytic activity even comparable...
SARS-CoV-2 has been confirmed in over 450 million cases since 2019. Although several vaccines have certified by the WHO and people are being vaccinated on a global scale, it reported that multiple variants can escape neutralization antibodies, resulting vaccine breakthrough infections. Bacillus Calmette-Guérin (BCG) is known to induce heterologous protection based trained immune responses. Here, we investigated whether BCG-induced immunity protected against K18-hACE2 mouse model. Our data...
Among the Omicron sublineages that have emerged, BA.1, BA.2, BA.5, and their related resulted in largest number of infections. While recent studies demonstrated all robustly escape neutralizing antibody response, it remains unclear on whether these share any pattern evolutionary trajectory replication efficiency intrinsic pathogenicity along respiratory tract.We compared virological features, capacity dominant BA.2 BA.5 human nasal epithelium, characterized K18-hACE2, A129, young C57BL/6,...
Successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requires proteolytic cleavage of the viral spike protein. While role host transmembrane protease serine in SARS-CoV-2 is widely recognized, involvement other proteases capable facilitating entry remains incompletely explored. Here, we show that multiple members from membrane-type matrix metalloproteinase (MT-MMP) and a disintegrin families can mediate entry. Inhibition MT-MMPs significantly reduces replication...
Chronic pain can cause both hyperalgesia and anxiety symptoms. However, how the two components are encoded in brain remains unclear. The prelimbic cortex (PrL), a critical region for nociceptive emotional modulations, serves as an ideal medium comparing encoded. We report that PrL neurons projecting to basolateral amygdala (PrLBLA) those ventrolateral periaqueductal gray (PrLl/vlPAG) were segregated displayed elevated reduced neuronal activity, respectively, during chronicity. Consistently,...
SARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated immune resistance of but factors are speculated contribute global dominance, which remain elusive until today. Here, we find that a higher infectivity than in differentiated primary human nasal epithelial cells (hNECs). Mechanistically, demonstrate gained over associates increased...
The creation of novel crown ether-paraquat polypseudorotaxane networks, constructed by bisparaquat monomers threading into the cavity ether units linear supramolecular polymers that are formed based on quadruple hydrogen bonded unit ureidopyrimidinone (Upy) in concentrated solution, is described.