The drug delivery system based on supramolecular vesicles that were self-assembled by a novel host–guest inclusion complex between water-soluble pillar[6]arene (WP6) and hydrophobic ferrocene derivative in water has been developed. complexation WP6 was studied 1H NMR, UV–vis, fluorescence spectroscopy, which showed high binding constant of (1.27 ± 0.42) × 105 M–1 with 1:1 stoichiometry. This resulting could self-assemble into displayed significant pH-responsive behavior aqueous solution,...

Supramolecular binary vesicles based on the host–guest complexation of water-soluble pillar[6]arene (WP6) and SAINT molecule have been successfully constructed, which showed pH-, Ca2+-, thermal-responsiveness. These supramolecular can efficiently encapsulate model substrate calcein, then be released either by adjusting solution pH to acidic condition due complete disruption vesicular structure, or particularly, adding a certain amount Ca2+ Ca2+-induced vesicle fusion accompanied structure...

ConspectusSupramolecular complexes, including various low-molecular-mass structures and large molecular aggregates that are assembled by reversible highly directional noncovalent interactions, have attracted more attention due to their fascinating unconventional chemical physical properties different from those of traditional architectures encountered covalently linked backbones. Supramolecular complexes nature dynamic considering the reversibility interactions which small monomers can...

The swelling-shrinking transition of hydrogels is crucial for their wide applications such as actuators and drug delivery. We hereby fabricated a smart hydrogel with ferrocene groups on pendant polymer networks. While it was immersed in the water-soluble pillar[6]arene (WP6) aqueous solution, dramatically swollen, which an approximately 11-fold promotion weight compared that pure water, due to formation inclusion complexes between WP6 hydrogel. In particular, well-swollen exhibited good...

Ureidopyrimidinone functionalized pillar[5]arene (UPyP5) was synthesized and employed to complex with a bisparaquat derivative (G) form supramolecular polymers at relatively high concentration. The orthogonal binding interactions including quadruple hydrogen bonding host–guest interaction should play vital roles in the construction of this linear assembly.

Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles with cyclic ethers were developed under mild conditions. In particular, the formation C–C bonds via CDC between non-benzo-fused azoles and are reported for first time. addition, acetals, known as masked 2-thiazolecarboxaldehydes, could be successfully obtained by this reaction. The preliminary mechanism supportive DFT calculations discussed well.

Novel dynamic polyrotaxanes constructed from pillar[5]arenes as wheels and diamines axles have been successfully synthesized in good yield using quadruple hydrogen bonding ureidopyrimidinone (UPy) motifs, which play a dual role the end-capping interlocking units. The present study is first example of noncovalent bonded by multiple interactions.

A novel and highly stable inclusion complex was formed between per-butylated pillar[6]arene a ferrocenium cation, while the reduced form ferrocene only showed extremely weak binding affinity with in organic solvents.

GSH- and pH-responsive supramolecular vesicles constructed by a host–guest inclusion complex formed from water-soluble pillar[5]arene lysine derivative were successfully developed.

Novel linear supramolecular polypseudorotaxanes constructed from bifunctional ureidopyrimidinone (UPy) pillar[5]arene as the wheel and alkyl diamine axle were successfully prepared. This polymer was stabilized by combination of two different non-covalent interactions: quadruple hydrogen bonding pillararene-based host–guest interactions.

A bis-urea-functionalized pillar[5]arene has been synthesized and shown to form [2]pseudorotaxanes spontaneously with linear alkyl dicarboxylates in highly polar solvent DMSO, which the hydrogen bonding interactions between bis-urea hydrogens dicarboxylate oxygens play an important role stabilizing novel alongside C–H⋯π interactions.

A linear pillar[5]arene-modified conjugated polymer was synthesized, and novel side-chain polypseudorotaxanes were formed via the host–guest interactions between pillar[5]arene unit n-octylpyrazinium salt. Compared with which shows strong fluorescence, show very weak fluorescence due to efficient electron transfer from backbone cation. Moreover, upon addition of chloride anion solution polypseudorotaxanes, a disassembly process occurred, leading recovery polymer. Therefore, could serve as an...

Recent progress of functional nanocarriers fabricated by pillar[<italic>n</italic>]arene-based supra-amphiphiles is reviewed.

Abstract Two novel types of supramolecular nanocarriers fabricated by the amphiphilic host–guest inclusion complex formed from water‐soluble pillar[6]arene ( WP6 ) and azobenzene derivatives G1 or G2 have been developed, in which is structurally similar to but has an extra phenoxy group its hydrophobic region. Supramolecular micelles can be initially with , gradually transform into layered structures liquid‐crystalline properties, whereas stable vesicles are obtained exhibit dual photo‐...

The recent progress in dynamic hydrogels mediated by macrocyclic host–guest interactions is reviewed.

Photoresponsive materials (PRMs) have long been a hot topic and photo‐modulated smart surface is very appealing. Particularly, liquid crystalline PRMs are able to amplify stabilize photoinduced orientation thanks their self‐assembling ordering characteristics. Herein, the first pillararene‐based azobenzene PRM with well‐defined structure presented, which can avoid usually ill‐defined composition drawback of polymer prevent severe H‐aggregation from suppressing or even completely blocking...

The constructing of novel supramolecular prodrug nanoparticles based on the host–guest interaction water-soluble pillar[6]arene (WP6) and doxorubicin (DOX)-based prodrugs (G1 or G2) is reported, in which these two kinds are synthesized by conjugating DOX with a flexible alkyl chain short EGn via an acid-cleavable hydrazone bond. obtained stable under physiological conditions, whereas cumulative release approximate to 100% within 30 min at pH 5.5 simulating endolysosomal environment 37 °C. It...

Controlling molecular motion is one of hot topics in the field chemistry. Molecular rotors have wide applications building nanomachines and functional materials, due to their controllable rotations. Hence, development novel rotor systems, controlled by external stimuli, desirable. Pillar[n]arenes, a class macrocycles, unique planar chirality, which two stable conformational isomers pR pS would interconvert oxygen-through-the-annulus rotations hydroquinone rings. We observe differential...

A novel pillar[5]arene-based supramolecular polypseudorotaxane network constructed by orthogonal self-assembly has been successfully fabricated. The obtained polymer was formed a combination of two different non-covalent interactions, quadruple hydrogen bonding and pillararene-based host–guest interactions. Furthermore, translucent film could be generated from the this with PEG-2000 as matrix. present study will provide convenient efficient way for creation advanced materials.

The creation of novel crown ether-paraquat polypseudorotaxane networks, constructed by bisparaquat monomers threading into the cavity ether units linear supramolecular polymers that are formed based on quadruple hydrogen bonded unit ureidopyrimidinone (Upy) in concentrated solution, is described.

Five bis-cyclometalated iridium complexes with tifluoromethyl-substituted 2-phenylpyridine (ppy) at different positions of its phenyl group as the main ligands and tetraphenylimidodiphosphinate (tpip) ancillary ligand, 2-6 (1 is a trifluoromethyl-free complex), were prepared, their X-ray crystallography, photoluminescence, electrochemistry investigated. The number trifluoromethyl groups ring ppy greatly affected emission spectra Ir(3+) complexes, corresponding peaks 533, 502, 524, 480, 542...

Squaramide-based tripodal anion receptors 1–3 have been prepared and their binding properties with various inorganic anions were investigated. Receptor 1 formed a dimeric complex in solid state : solution SO42−. All could selectively encapsulate SO42−via hydrogen bonds over other examined anions.