A5103094678- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Astro and Planetary Science
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- High-pressure geophysics and materials
- earthquake and tectonic studies
- Catalytic Cross-Coupling Reactions
- Synthesis of heterocyclic compounds
- Electrochemical sensors and biosensors
- Synthesis and Biological Evaluation
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Single-cell and spatial transcriptomics
- Microwave-Assisted Synthesis and Applications
- Synthesis and Characterization of Pyrroles
- Porphyrin and Phthalocyanine Chemistry
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Boron Compounds in Chemistry
Yunnan University of Traditional Chinese Medicine
2025
Nanjing Drum Tower Hospital
2024
Jining Medical University
2016-2024
Nanjing University
2012-2014
Yangzhou University
2007-2010
Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles with cyclic ethers were developed under mild conditions. In particular, the formation C–C bonds via CDC between non-benzo-fused azoles and are reported for first time. addition, acetals, known as masked 2-thiazolecarboxaldehydes, could be successfully obtained by this reaction. The preliminary mechanism supportive DFT calculations discussed well.
Oxidation of B-tolyl B III 5,10,15-tritolylsubporphyrin with tris(4-bromophenyl)ammoniumyl hexachloroantimonate gave its cation radical instantaneously, which slowly dissociated to give subporphyrin borenium in 89% after stirring overnight. This is a...
A DBU-mediated, unprecedented formal ring expansion reaction of 2-acyl-3-arylcyclopropane-1,1-dicarbonitriles for the synthesis multisubstituted furan derivatives is reported. This transformation represents regioselective ring-opening cyclopropane-1,1-dicarbonitriles and annulation using an intramolecular addition cascade protocol fully substituted furans includes use readily available starting materials, mild conditions, it transition-metal catalyst free, has good functional tolerance,...
An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This proceeded smoothly and tolerated variety functional groups (44 examples). A wide range functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles the also discussed.
A DBU-promoted cascade annulation of nitroarylcyclopropane-1,1-dicarbonitriles and 3-aryl-2-cyanoacrylates for the synthesis highly functionalized cyclopenta[ b]furan derivatives is described. High stereoselectivity, fused cyclopentane furan can be established in a single reaction, highlighting high efficiency step-economy this protocol. This reaction offers novel straightforward protocol to b]furans featuring [3 + 2] cycloadditions with 3-aryl-2-cyanoacrylates.
Abstract The ring‐opening/cyclization reactions of substituted 2‐acyl‐3‐arylcyclopropane‐1,1‐dicarbonitriles with thiourea promoted by K 2 CO 3 were investigated successfully. Using the reaction, desired 2‐amino‐4,6‐diarylnicotinonitrile derivatives obtained in good to excellent yields. This work provides a new strategy for synthesis derivatives.
Highly efficient and practical carbon–chalcogen (S, Se) amide bonds formation methodologies for the synthesis of thio- seleno-acetamides were developed, via base-promoted one-pot two-step reactions 2-amino(benzo)thiazoles aryl acetyl chlorides with dichalcogenides. This cross-coupling reaction afforded goal products that had been chalcogenated regioselectively in moderate to good yields. Further transformations new synthesized compounds, DFT calculations preliminary mechanism studies are...
Photodynamic Therapy (PDT) offers a promising minimally invasive treatment for breast cancer, but its efficacy is limited by the hostile tumor microenvironment (TME), including hypoxia and high glutathione (GSH) levels. Although various strategies to improve oxygen concentration or reduce reactive species (ROS) resistance enhanced PDT have been explored, they typically require intricate design complex synthesis of multifunctional nanocarriers. Thus, this study introduces facile K
Abstract Some N ‐tosylhydrazone derivatives were effectively synthesized under solvent‐free conditions by using a grinding method at room temperature. The short reaction time, clean and mild process with simple workup easy purification of the target compounds salient features present protocol, which enables straightforward access to ‐tosylhydrazones. Among tosylhydrazone evaluated, compound 3 l exhibits excellent apoptosis‐promoting anticancer potential against triple‐negative breast cancer...
Abstract A practical and efficient methodology for the synthesis of aromatic primary amides by reaction benzylic alcohols aqueous ammonia in presence an I 2 /TBHP system acetonitrile was developed. This oxidative amidation proceeded smoothly at ambient temperature tolerated a variety functional groups. wide range were obtained moderate to high yields. Preliminary kinetic studies possible mechanism also discussed.
Some substituted quinolines were effectively synthesized utilizing chlorotrimethylsilane (TMSCl) as efficient promoter in the cyclization addition of enolizable aldehydes to arylimines under an air atmosphere DMSO.The clean, mild and ecofriendly process with high yields a simple workup desired compounds are attractive features reaction which enables facile preparation quinoline ring.
An efficient and practical C–N bond formation methodology for the synthesis of N ‐alkylated (benzo)thiazoles was developed, via copper‐catalyzed one‐pot two‐step reactions 2‐amino(benzo)thiazoles aldehydes (ketones) with tosylhydrazide. This cross‐coupling reaction proceeded smoothly tolerated a broad range functional groups (46 examples). A variety functionalized were obtained in moderate to high yields. Notably, gram‐scale fanetizole (anti‐inflammatory drug) also realized through this protocol.
Abstract An eco‐friendly, straightforward, and three‐component [2+2+2] cycloaddition reaction of 4‐aryliden‐2‐phenyl‐5(4H)‐oxazolones substituted β‐nitrostyrenes to construct diversified 3‐oxa‐1‐azaspiro[4.5]dec‐1‐en‐4‐ones has been developed with good yields regio‐ diastereoselectivity. This proceeds via a one‐pot utilizing cesium carbonate as promoter shows high atom economy under the conditions.