A5072333505- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Viral gastroenteritis research and epidemiology
- Gait Recognition and Analysis
- Advanced Graph Neural Networks
- Data Quality and Management
- Lipid metabolism and biosynthesis
- Arsenic contamination and mitigation
- Animal Disease Management and Epidemiology
- Microtubule and mitosis dynamics
- Heat shock proteins research
- Vitamin C and Antioxidants Research
- Photodynamic Therapy Research Studies
- Topic Modeling
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Anomaly Detection Techniques and Applications
- Ferroptosis and cancer prognosis
- Human Pose and Action Recognition
- Genomics, phytochemicals, and oxidative stress
- interferon and immune responses
City University of Hong Kong
2017-2024
Chinese University of Hong Kong
2024
Prince of Wales Hospital
2024
City University of Hong Kong, Shenzhen Research Institute
2023
Rutgers, The State University of New Jersey
2017
Oxidative stress (OS) is recognized as a contributing factor in the development and progression of thyroid cancer. Nuclear erythroid 2-related 2 (Nrf2) pivotal transcription involved against OS generated by excessive reactive oxygen species (ROS). It governs expression wide array genes implicated detoxification antioxidant pathways. However, studies have demonstrated that sustained activation Nrf2 can contribute to tumor drug resistance cancers. The was notably elevated papillary cancer...
Abstract The crucial role of interferon (IFN) signaling is well known in the restriction or eradication pathogen invasion. Viruses take a variety ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades. However, way by viruses target extracellularly has not been discovered. Infection both coronavirus SARS-CoV-2 and enterovirus 71 (EV71 EV-A71) can cause severe diseases such as neurological disorders even death children. 1–3 Here, we show evidence that...
Enterovirus 71 (EV-A71) is a human pathogen that causes hand, foot, and mouth disease (HFMD) fatal neurological diseases, no effective treatment available. Characterization of key host factors important for understanding its pathogenesis developing antiviral drugs. Here we report Hsp27 one the most upregulated proteins in response to EV-A71 infection, as revealed by two-dimensional gel electrophoresis-based proteomics studies. Depletion small interfering RNA or CRISPR/Cas9-mediated knockout...
We present a method for activity recognition that first estimates the performer's location and uses it with input data recognition. Existing approaches directly take video frames or entire feature extraction recognition, treat classifier as black box. Our locates activities in each frame by generating an mask using conditional generative adversarial network (cGAN). The generated is appended to color channels of images fed into VGG-LSTM To test our system, we produced two datasets manually...
Cholecystokinin (CCK) has been confirmed to be essential in NMDA-dependent long-term potentiation (LTP) at mouse cortical synapses. This paper proven that CCK is necessary for LTP induced by high-frequency stimulation of hippocampal synapses projected from the entorhinal cortex. We show subunit axonal NMDA receptor dominant modulates activity-induced triggering pre-synaptic release. A functional required induce mediated Ca
Knowledge reasoning technology can infer new knowledge based on the existing entity relationship information in graph to complement graph. In methods multi-step paths, contributions of entities and relationships paths are not distinguished, nor multiple comprehensively considered. To solve these problems, we propose a model Bi-directional Short-Term Memory Attention Mechanism. Firstly, neighborhood, semantic category path integrated graph, Neighborhood Semantic Path Network (NSPN) is...