A5085543510- Angiogenesis and VEGF in Cancer
- Virology and Viral Diseases
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Pancreatic and Hepatic Oncology Research
- Inhalation and Respiratory Drug Delivery
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- Sepsis Diagnosis and Treatment
- RNA Research and Splicing
- Viral Infectious Diseases and Gene Expression in Insects
- Acute Myeloid Leukemia Research
- Mosquito-borne diseases and control
- Mitochondrial Function and Pathology
- Pneumonia and Respiratory Infections
- Machine Learning in Bioinformatics
- Ion channel regulation and function
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
The First People’s Hospital of Lianyungang
2016-2025
Heidelberg University
2025
Xian Yang Central Hospital
2016-2023
Tongji Hospital
2022
Huazhong University of Science and Technology
2022
Sun Yat-sen University
2021
Sun Yat-sen University Cancer Center
2021
Chinese University of Hong Kong
2017
Hebei University
2013
Abstract Colorectal cancer, one of the most commonly diagnosed cancers worldwide, is often accompanied by uncontrolled proliferation tumor cells. Dyskerin pseudouridine synthase 1 (DKC1), screened using genome‐wide RNAi strategy, a previously unidentified key regulator that promotes colorectal cancer cell proliferation. Enforced expression DKC1, but not its catalytically inactive mutant D125A, accelerates growth in vitro and vivo. DKC1 knockdown or inhibitor pyrazofurin attenuates...
The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 mice were randomly divided into fi ve groups: model control gourp; plus 40, 80, 120 mg/kg body wt. groups and metformin 250 group. Age-matched db/m selected as normal administered with corresponding drugs or solvent by gavage for 4 weeks. oral glucose tolerance test carried out at end 3rd week. After weeks treatment, concentrations fasting blood (FBG), glycated serum protein (GSP),...
The prognostic significance of dynamic changes in the albumin-to-C-reactive protein ratio (ACR) elderly patients with community-acquired pneumonia (CAP) has not been fully elucidated. This study aims to evaluate utility ACR as a biomarker for predicting 28-day mortality and enhancing risk stratification this high-risk population. A retrospective cohort was conducted on 437 CAP (≥65 years). Serum albumin C-reactive (CRP) levels were measured at admission (T0), 24 hours (T1), 3 days (T2)...
Background. Acute myeloid leukemia (AML) is a malignant clonal disease of the hematopoietic system. Clinically, standard treatment options include conventional chemotherapy as well stem cell transplantation. Among them, has remission rate 60% to 80% and nearly 50% relapse in consolidation therapy. Some patients have poor prognosis due presence unfavorable factors such advanced age, hematologic history, karyotype, severe infection, organ insufficiency, which cannot tolerate or are not...
Rh-endostatin is a potent inhibitor of angiogenesis approved and widely used for advanced non-small cell lung cancer (NSCLC) in China. While the efficacy safety extended use rh-endostatin with platinum-based chemotherapy during induced maintenance therapy are still not very clear, whether can improve survival needs further investigation.We performed retrospective analysis chemotherapy-naïve patients stage IIIB-IV or recurrent NSCLC who had been treated first-line plus between January 2008...
Abstract Background and aim DRP1 OPA1 play important roles in mitochondrial fusion fission. However, the role of amplification cognitive impairment has not been reported. This study aimed to investigate relationship between risk impairment. Methods A total 45 elderly patients with diabetes were enrolled this study, including 15 normal diabetes, mild (MCI), dementia. Also, clinical characteristics, AD8 score, MoCA score evaluated. Results DRP1(2-K) OPA1(2-K) significantly increased decreased...