A5101962295- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Selenium in Biological Systems
- Inflammasome and immune disorders
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Endometrial and Cervical Cancer Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Heme Oxygenase-1 and Carbon Monoxide
- IL-33, ST2, and ILC Pathways
- Biomarkers in Disease Mechanisms
- Endometriosis Research and Treatment
- Respiratory Support and Mechanisms
- Autophagy in Disease and Therapy
- Sperm and Testicular Function
- MicroRNA in disease regulation
- Air Quality Monitoring and Forecasting
- Energy and Environment Impacts
- Pesticide Exposure and Toxicity
- Immune cells in cancer
- Medical and Biological Ozone Research
Shandong University
2020-2022
Weifang Medical University
2019-2022
Shandong Maternal and Child Health Hospital
2022
National Health and Family Planning Commission
2020-2021
Silica is an essential substrate of various materials, and inhaling silica induces pulmonary diseases potentially associated with macrophage pyroptosis. Utilizing micro- nano- sizes, we explored the role pyroptosis in silica-induced inflammation. Under transmission electron microscopy, found that internalization nanoparticle induced membrane rupture increased number intracellular vacuoles, both sizes could suppress cell viability proliferation. Also, silica-exposed macrophages generated...
Abstract Extensive application of nanomaterials has dramatically increased the risk silica nanoparticle (SiNP, SiO 2 ) exposure, yet their biological effect on reproduction not been fully elucidated. By tracking uterine biodistribution SiNP in pregnant mice, this study was conducted to evaluate reproduction. First, conjugated with FITC, and then FITC-SiNP administrated trophoblast (100 µg/mL, 24 h) vitro mice (0.25 mg/mouse, 2–24 vivo. It found that internalized by deposited uterus. The...
Introduction: Silica nanoparticles (SiNPs) are one of the most widely used inorganic nanomaterials, and exposure to SiNP has been demonstrated induce pulmonary inflammation, primarily promoted by NLRP3-mediated macrophage pyroptosis. However, mechanisms underlying activation NLRP3 signaling complex, whether cathepsin B (CTSB), an enzyme released ruptured lysosome, could trigger assembly is controversial. Methods: To further characterize role CTSB in silica-induced pyroptosis, we conducted...
Abstract Long‐term exposure to respirable silica particles causes pulmonary inflammation and fibrosis primarily promoted by cytokines released from alveolar macrophages, yet the underlying mechanism is still unclear. From perspective of nuclear factor kappa B (NF‐κB), we studied IL‐1β biosynthesis release. Utilizing BAY 11‐7082, an NF‐κB specific inhibitor, showed alteration macrophage viability examined expression both in vitro. We found that nanoparticles (SiNPs) were internalized...
Previous studies have demonstrated that silica nanoparticle (SiNP) exposure induces pulmonary and cardiovascular diseases, yet their transportation degradation in vivo not been fully elucidated. From the perspective of reproduction, this study was implemented to examine uterine accumulation SiNP explore its reproductive toxicity pathogenic mechanisms. First, we coupled FITC onto SiNPs intratracheally instilled them into pregnant mice on fifth gestational day, toxic effect evaluated vitro...
Autophagy is essential for cellular metabolism and plays pivotal roles in carcinogenesis, while excessive autophagy induces toxicity cell death. Our previous studies have suggested that let-7a-5p/BCL-xL might regulate lung cancer, but the regulatory mechanism unclear. The central goal of study was to figure out role initiation its effect on migration, invasion, proliferation A549 cells as well therapeutic potential cancer. Based genome-wide expression profiles BCL-xL let-7a-5p were found be...
Endometriosis is widely associated with infertility in women of childbearing age, for which there have been no effective treatments.Recent studies suggest that the dysregulation RNAs contributes to pathogenesis endometriosis, so we conduct case-control genetic analysis characterize expression and interaction different subtypes infertile endometriosis.The ectopic eutopic endometrium patients undergoing treatment were collected subjected high throughput sequencing, bioinformatics was conducted...
This study quantitatively evaluated the effects of pyrethroid pesticides on testis male rats. An extensive literature search for relevant studies was conducted PubMed, Web Science, Excerpta Medica Database, Chinese National Knowledge Infrastructure, and Biomedical Literature Database. Pooled standard mean difference with corresponding 95% confidence interval calculated via random-effects model. I 2 used to evaluate heterogeneity among studies. A total 19 were included analysis in our study....