A5085087593- Systemic Lupus Erythematosus Research
- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Atherosclerosis and Cardiovascular Diseases
- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Genetic Mapping and Diversity in Plants and Animals
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Functional Brain Connectivity Studies
- Gastrointestinal disorders and treatments
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Cancer Mechanisms and Therapy
- Renal and related cancers
- RNA modifications and cancer
- Alkaline Phosphatase Research Studies
- Hypothalamic control of reproductive hormones
- 14-3-3 protein interactions
- Cancer Research and Treatment
- Medicinal plant effects and applications
Kunming Medical University
2020-2025
First Affiliated Hospital of Kunming Medical University
2020-2025
China Three Gorges University
2025
Sinopharm Gezhouba Central Hospital
2025
Chinese Academy of Agricultural Sciences
2017-2024
Shenzhen Second People's Hospital
2024
Qingdao Agricultural University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Xuzhou Medical College
2023
Second People’s Hospital of Huai’an
2023
Abstract The Einstein Probe (EP) is an interdisciplinary mission of time-domain and X-ray astronomy. Equipped with a wide-field lobster-eye focusing imager, EP will discover cosmic transients monitor the variability known sources in 0.5–4 keV, at combination detecting sensitivity cadence that not accessible to previous current monitoring missions. can perform quick characterisation or outbursts Wolter-I telescope onboard. In this paper, science objectives are presented. expected enlarge...
Abstract Background Animal domestication has been extensively studied, but the process of feralization remains poorly understood. Results Here, we performed whole-genome sequencing 99 sheep and identified a primary genetic divergence between 2 heterogeneous populations in Tibetan Plateau, including 1 semi-feral lineage. Selective sweep candidate gene analysis revealed local adaptations these associated with sensory perception, muscle strength, eating habit, mating process, aggressive...
The expression characteristics of the prolific candidate genes, BMPR1B, BMP15, and GDF9, in major visceral organs hypothalamic⁻pituitary⁻gonadal (HPG) axis tissues three FecB genotypes (FecB BB, B+, ++) were explored STH ewes using RT-PCR qPCR. results as follows, BMPR1B was expressed all BB genotype (Han BB) tissues, GDF9 selected but BMP15 specifically ovaries. Further study ovarian indicated that there no difference between genotypes, B+ B+) had greater than Han ++ (p < 0.05, p 0.01)....
Agents targeting the programmed death ligand 1 (PD-L1)/programmed receptor immune checkpoint exhibited promising clinical outcomes in a variety of malignant tumors, including intrahepatic cholangiocarcinoma (ICC). However, relationship between PD-L1 expression and CD8+ T-cell responses is not well defined ICC.We investigated immunohistochemistry formalin-fixed, paraffin-embedded tissues from 192 ICC patients undergoing curative resection correlated our results with clinicopathologic features...
Litter size is one of the most important economic traits in sheep. GDF9 and BMPR1B are major genes affecting litter In this study, whole coding region was sequenced all SNPs (single nucleotide polymorphisms) were determined Luzhong mutton ewes. The FecB mutation genotyped using Sequenom MassARRAY®SNP assay technology. Then, association analyses between polymorphic loci gene, FecB, performed a general linear model procedure. results showed that eight detected sheep, including novel...
Sheep have developed the ability to store fat in their tails, which is a unique way of reserving energy survive harsh environment. However, mechanism underlying this adaptive trait remains largely unsolved.In present study, we provide evidence for genetic determinants based on whole genome sequences 89 individual sheep. A genome-wide scan selective sweep identified several candidate loci including region at chromosome 13, haplotype underwent rapid evolution and spread through fat-tailed...
Systemic lupus erythematosus patients' brain functional network impairments are incompletely clarified. This study investigates the topological alterations in systemic and application of machine learning to classification healthy controls. Resting-state MRI data from 127 patients 102 controls were used. The pre-processing process involved using automated anatomical labelling atlas compute time series for 116 regions. A connectivity was then created by assessing Pearson correlation between...
To study changes in blood brain barrier (BBB) permeability systemic lupus erythematosus (SLE) patients, and explore the association between alterations BBB depression/anxiety SLE. Brain dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) images were collected from 42 SLE patients 23 healthy controls (HCs). Based on Patlak pharmacokinetic model, Ktrans value of each voxel whole subject was calculated. indicator (the value) control group compared. Hamilton Depression Scale (HAMD)...
The treatment of refractory and recurrent acute myeloid leukaemia (AML) is still a challenge with poor response rates short survival times. In an attempt to solve this problem, we constructed tandem bispecific chimeric antigen receptor (CAR) targeting CD123 C-type lectin-like molecule 1 (CLL-1), two different AML antigens, verified its cytotoxic effects in vitro.We established cultured K562 cell lines expressing both CLL1 antigens. Single-target CAR-T cells specific were engineered,...
A new fecundity gene named the FecL (mutation), which regulates ovulation rate, was discovered in French Lacaune sheep. The B4GALNT2 (beta-1, 4-N-acetyl-galactosaminyl transferase 2) considered as potential mutation gene. This study explores whether effect of exists other sheep breeds, and features terms molecular structure its expression profile. Using Sanger sequencing, we found that high low breeds from among 11 measured all had no variation three specific sites, were linked with...
This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, treatment regimens in patients systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE normal conventional magnetic resonance imaging (MRI) seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. The...
Abstract Background Non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has been confirmed to have subtle changes in brain structure before the appearance of obvious neuropsychiatric symptoms. Previous literature mainly focuses on loss non-NPSLE; however, results are heterogeneous, and impact structural topological patients’ networks remains be determined. In this study, we combined neuroimaging network analysis methods evaluate cortical thickness its covariance (SCNs) patients...
Abstract. Litter size is one of the key factors affecting efficiency sheep breeding, and previous studies found that HRG, FETUB, GUCY1A1 genes were closely related to litter in sheep. This experiment aims explore polymorphisms g.405442728A>G locus HRG gene, g.421655951C>T FETUB g.414050897G>C gene their association with size. The MassARRAY® single-nucleotide polymorphism (SNP) genotyping technique was used detect these loci five breeds, i.e., Small-tailed Han sheep, Hu Cele black...
Like most seasonal domesticated species, sheep are short-day breeders, which means that the reproduction axis is activated by short days. The annual photoperiodic cycle affects amount of daylength information transmitted to hypothalamic-pituitary-gonadal (HPG) regulating pulsatile secretion gonadotrophin-releasing hormone from hypothalamus. Kisspeptin, encoded Kiss1, plays a major role in reproductive seasonality. Based on results our previous Solexa sequencing data obtained Tan (T) and...
Abstract Prolificacy of most local goat breeds in China is low. Jining Grey one the prolific China, it an important breed for rural economy. ASMT (acetylserotonin O‐methyltransferase) and ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif) are essential animal reproduction. Single nucleotide polymorphisms (SNPs) genes highly (Jining goats), medium (Boer goats Guizhou White goats) low (Angora goats, Liaoning Cashmere Inner Mongolia were detected by polymerase chain...