A5101486874- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- Acute Ischemic Stroke Management
- Immune Cell Function and Interaction
- Spinal Cord Injury Research
- Breast Cancer Treatment Studies
- Palliative Care and End-of-Life Issues
- Cardiac Imaging and Diagnostics
- HER2/EGFR in Cancer Research
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Streptococcal Infections and Treatments
- Economic and Financial Impacts of Cancer
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Neurosurgical Procedures and Complications
- Digestive system and related health
- CAR-T cell therapy research
- Breast Implant and Reconstruction
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Forensic Fingerprint Detection Methods
- Viral-associated cancers and disorders
- Image Processing and 3D Reconstruction
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
The First People's Hospital of Xiaoshan District, Hangzhou
2022-2024
Wenzhou Medical University
2024
Jiangsu University
2024
Yixing People's Hospital
2024
First Affiliated Hospital of GuangXi Medical University
2022-2023
Nanjing University of Chinese Medicine
2022-2023
Guangxi Medical University
2017-2023
Peking Union Medical College Hospital
2023
Center for High Pressure Science & Technology Advanced Research
2022-2023
Objective: The current study aims to investigate the prognostic value of breast cancer integrated oxidative stress score (BCIOSS) in patients with who received neoadjuvant chemotherapy (NACT). Methods: A retrospective analysis 104 underwent NACT from June 2009 December 2015 was performed. differences BCIOSS cancers regard variables were analyzed using Chi-square test and Fisher's exact test. Kaplan-Meier method used evaluate survival curve between low group high group, two groups compared by...
Injury of renal tubular epithelial cells is a key feature the pathogenicity associated with tubulointerstitial fibrosis and other kidney diseases. HUWE1, an E3 ubiquitin ligase, acts by participating in ubiquitination degradation its target proteins. However, detailed mechanisms which HUWE1 might regulate have not been established. Here, possible regulation was investigated examining expression EGFR unilateral ureteral obstruction (UUO) mice. Markedly consistent reciprocal changes were...
Melatonin can be neuroprotective in models of neurological injury, but its effects on blood vessel loss and impairment following spinal cord injury (SCI) are unclear. Our goal herein was to evaluate the possible protective action melatonin above SCI-induced damage rats.Sixty-three female Sprague-Dawley rats were randomly divided into three equal groups: sham, SCI groups. (10 mg/kg) injected intraperitoneally further administered twice a day at indicated time after moderate T10 group. Blood...
Previous radiomics analyses of hematoma expansion have been based on the traditional definition, which only focused changes in intraparenchymal volume. However, ability radiomics-related models to predict revised (RHE) with inclusion intraventricular hemorrhage remains unclear. To develop and validate a noncontrast computed tomography (NCCT)-based clinical- semantic-radiomics nomogram identify supratentorial spontaneous intracerebral (sICH) patients RHE admission.In this double-center...
This study aimed to employ deep learning techniques analyze and validate an automatic prognostic biomarker for predicting outcomes following intracerebral hemorrhage (ICH).
Abstract Background Epicardial adipose tissue (EAT) is known as an important imaging indicator for cardiovascular risk stratification. The present study aimed to determine whether the EAT volume (EV) and mean attenuation (mEA) measured by non-contrast routine chest CT (RCCT) could be more consistent with those coronary angiography (CCTA) adjusting threshold of fatty attenuation. Methods In total, 83 subjects who simultaneously underwent CCTA RCCT were enrolled. EV mEA quantified using a...
Electroacupuncture (EA) is a form of physical therapy that has been widely used in clinical practice China. Post-stroke depression (PSD) the most common neuropsychiatric complication after stroke. EA shown to have beneficial effects on PSD patients. However, potential mechanism underlying protective remains unclear. Here, we investigated whether tissue plasminogen activator (tPA)/brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) signaling pathway participates...
Abstract 7-Met, a derivative of soybean isoflavone, is natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). ameliorated FITC OXZ-induced symptoms decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced...
Abstract Objective To develop and validate a radiomics nomogram based on computed tomography (CT) to distinguish appendiceal mucinous neoplasms (AMNs) from appendicitis with intraluminal fluid (AWIF). Method A total of 211 patients two medical institutions were retrospectively analysed, which 109 pathologically confirmed as having concomitant CT signs 102 AMN. All randomly assigned training (147 patients) or validation cohort (64 at 7:3 ratio. Radiomics features the cystic area lesions...
Abstract Objective The prevalence and mortality of cardiovascular diseases remain ranked first worldwide. Myocardial infarction (MI) is the central cause death from diseases, seriously endangering human health. clinical implication toll-like receptor 2 (TLR2) remains contradictory, its mechanism still unknown. Hence, objective this study was to elucidate value molecular TLR2 in MI. Methods All high-throughput datasets eligible literature were screened, expression levels collected integrated...
Abstract The clinical features of EBV-positive diffuse large B cell lymphoma (DLBCL) indicate a poorer prognosis than EBV-negative DLBCL. Currently, there is no efficacious drug for cytokine interleukin-21 (IL-21) has been reported to be pro-apoptotic in DLBCL lines and being explored as new therapeutic strategy this type lymphomas. However, our previous studies showed that IL-21 stimulation leads increased proliferation. Here, analysis rare sample DLBCL, combination with NOD/SCID mouse...
This study aimed to investigate the usefulness of a new non-contrast CT scan (NCCT) sign called dHU, which represented difference in mean Hounsfield unit values between follow-up and initial NCCT for predicting 90-day poor functional outcomes acute supratentorial spontaneous intracerebral hemorrhage(sICH) using deep convolutional neural networks.A total 377 consecutive patients with sICH from center 1 91 2 (external validation set) were included. A receiver operating characteristic (ROC)...
Abstract Background To investigate the potential role of immune-related genes (IRGs) and immune cells in myocardial infarction (MI) establish a nomogram model for diagnosing infarction. Methods Raw processed gene expression profiling datasets were archived from Gene Expression Omnibus (GEO) database. Differentially expressed (DIRGs), which screened out by four machine learning algorithms-partial least squares (PLS), random forest (RF), k-nearest neighbor (KNN), support vector (SVM) used...
The aim of this study was to estimate the effect melatonin on spinal cord perfusion, permeability blood-spinal barrier (BSCB), and edema at contusion epicenter regions rostral caudal injury site in rats with (SCI). Thirty-six female Sprague-Dawley were divided into three groups (12 animals each group): sham, SCI, groups. Melatonin (50 mg/kg) injected intraperitoneally 30 min after a moderate T10 group (twice day). At 24 h postinjury, perfusion estimated using laser Doppler flowmetry, BSCB...
This paper is about an interdisciplinary knowledge relating to computer science and solid state electronics. The normal FORMAT or DELET operation in can not verily eras the data on hard disk. By using precision instruments, could be recognized recovered. Based intensive study characteristic of magnetic medium encoding rules, this represents effective theory destruct from disk without specialized equipment. And finally, it proposes a feasible solution for destruction software Linux Windows...
Purpose:The aim of the present study was to investigate effect trastuzumab on pathological complete response (pCR) rate and event-free survival (EFS) in neoadjuvant-treated HER2-positive breast cancer with a low infiltrating level tumor-infiltrating lymphocytes (TILs).Patients Methods: The TILs evaluated hematoxylin eosin-stained slides from diagnostic needle biopsies, defined as < 10%.Data 179 patients were retrospectively reviewed compared according whether administered or not.The...
Background: The optimal timing of invasive coronary revascularization in patients with late presentation acute myocardial infarction (AMI) remains unclear. Objective: This study aimed to investigate whether percutaneous intervention (PCI) is associated the prognosis AMI HFpEF presenting > 24h after symptom onset. Methods: We enrolled 680 HFpEF. Patients were divided into 3 groups: early-PCI strategy (defined as time open IRA from onset < 24 h), late-PCI PCI-mediated reperfusion was h) and...
<title>Abstract</title> There is a lack of large cohort studies examining trends in cancer-related suicide. This study addresses this gap by analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database, encompassing total 4,870,410 patients diagnosed with cancer 1975 to 2017. Age-adjusted suicide rates were examined using joinpoint regression estimate annual percent change (APC) average percentage (AAPC). In past 40 years, have revealed gradual increase 1989, followed...
Inflammation markers have been proposed as the predictors of adverse cardiac events in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). This study aimed to investigate prognostic value serum cystatin C (Cys-C) for NSTE-ACS patients.Cys-C, neutrophil lymphocyte ratio (NLR) and high-sensitivity C-reactive protein (hsCRP) were examined 212 60 controls. Global registry (GRACE) score major (MACE) recorded.Cys-C level was significantly higher than control, positively correlated...