This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-synuclein (α-SYN) aggregates in substantia nigra (SN) Parkinson's disease (PD) mice via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced. Our results indicated that L. increased levels superoxide dismutase (SOD), glutathione peroxide (GSH-Px), and interleukin-10 (IL-10) decreased malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6),...

Abstract Phytochlorins, a class of plant‐derived tetrapyrroles, show great potential as sonosensitizers in sonodynamic therapy (SDT). The development new phytochlorin‐based has significantly improved SDT, yet the absence specialized systems limits their clinical translation. Herein, dedicated ultrasound system along with detailed step‐by‐step process from vitro to vivo is developed activate sonosensitizers. Compared standing‐wave ultrasound, free‐field maintains stable acoustic pressure...

In this study, we aimed to investigate the causal associations of brain structure with bone mineral density (BMD). Based on genome-wide association study (GWAS) summary statistics 1 325 imaging-derived phenotypes (BIDPs) from UK Biobank and GWAS datasets 5 BMD locations, including total body, femoral neck, lumbar spine, forearm, heel GEFOS Consortium, linkage disequilibrium score regression (LDSC) was conducted determine genetic correlations, Mendelian randomization (MR) then performed...

Purpose It has been reported that bone is the primary organ for manganese (Mn) accumulation, but association between and loss remains debatable. Therefore, this study aimed to evaluate relationship blood mineral density/bone content (BMD/BMC) by using a representative sample from National Health Nutrition Examination Survey (NHANES). Methods A total of 9732 subjects over age 18 with available data were enrolled in study. The BMD/BMC body, spine femoral regions was evaluated multivariate...

Abstract Background This retrospective study aimed to develop and validate a combined model based [ 18 F]FDG PET/CT radiomics clinical parameters for predicting recurrence in high-risk pediatric neuroblastoma patients. Methods Eighty-four patients were retrospectively enrolled divided into training test sets according the ratio of 3:2. images tumor segmented by 3D Slicer software features extracted. The effective selected least absolute shrinkage selection operator construct score...

Background: Rheumatoid arthritis (RA) is a globally prevalent chronic inflammatory disease. Environmental exposures, such as air pollution and smoking, are considered potential risk factors. However, the causal relationships underlying mechanisms between these factors RA not fully understood. Methods: This study utilized large-scale genome-wide association studies (GWASs) from European ethnic backgrounds employed bidirectional two-sample Mendelian randomization (MR) to investigate pollution,...

Postmenopausal female patients with a history of single hip fracture are at higher risk second fracture. The poorer clinical outcomes this patient group warrants evaluating the experiencing Therefore, study aimed to investigate effectiveness structural analysis (HSA) in assessing postmenopausal females. This retrospective included 188 selected from Chinese Second Hip Fracture Evaluation (ClinicalTrials.gov identifier: NCT03461237, first registration/posted date: 09/03/2018). They were...

Abstract Background Recent epidemiological studies have linked the central nervous system (CNS) to osteoarthritis (OA), suggesting that targeting CNS could offer new therapeutic strategies. This study aimed validate correlation between brain structures and OA risk, identify key causal genes by integrating transcriptomic proteomic data with genome-wide association (GWAS). Methods We analyzed summary statistics from 826,690 participants. Using linkage disequilibrium score regression (LDSC)...

Primary dysmenorrhea is a common disease in women. China, under the influence of their philosophical wisdom, has developed unique theories clinical disorders and corresponding therapeutic cultural practices, including application medical wisdom to treatment primary dysmenorrhea. The article reviews current Traditional Chinese medicine strategies for dysmenorrhea, acupuncture, moxibustion, acupoint application, diet improvement, lifestyle adjustment. This also analyzes benefits potential...

Background: Currently, the link between cardiovascular diseases and sarcopenia is increasingly garnering attention from researchers. However, studies exploring association cardiac structure are sparse. This study aims to investigate potential genetic links structural features sarcopenia. Methods: During discovery phase, we employed Linkage Disequilibrium Score Regression (LDSC) Mendelian Randomization (MR) assess correlation causality traits related sarcopenia, with further validation of...

Objective This study was aimed at evaluating the clinical efficacy and safety of transcutaneous electrical acupoint stimulation (TEAS) to treat muscle spasticity after brain injury (Chinese Clinical Trial Registry: ChiCTR-TRC-11001310). Methods A total 60 patients with were randomized following 3 groups: 100, 2, 0 Hz (sham) TEAS. The acupoints Hegu (LI4)—Yuji (LU10) Zusanli (ST36)—Chengshan (BL57) on injured side stimulated 0, or 100 Hz, 5 times per week for 4 weeks. followed up 1 2 months...

Peripheral facial paralysis is the dominant treatment disease of acupuncture. A large number studies have proved effectiveness acupuncture in peripheral paralysis. However, underlying biological effect remains an exploratory phase. This article will sort out and summarize existing research mechanisms from following aspects: inflammatory response, immune regulation, neurotransmitters, microcirculation, oxidative stress, changes nerve structure function, specificity acupoints, intervention...

Abstract Objective To develop and validate an 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)-based radiomics nomogram for non-invasively prediction of bone marrow involvement (BMI) in pediatric neuroblastoma. Methods A total 133 patients with neuroblastoma were retrospectively included randomized into the training set ( n = 93) test 40). Radiomics features extracted from both CT PET images. The signature was developed. Independent clinical risk...

Epidemiological studies have repeatedly investigated the association between obesity related anthropometric indicators and body compositions osteoarthritis (OA). However, results remained inconsistent. This work aimed to investigate genetic correlation causal associations of with knee hip OA.

Accurate differentiation of intermediate/high mitosis-karyorrhexis index (MKI) from low MKI is vital for the further management neuroblastoma. The purpose this research was to investigate efficacy 18F-FDG PET/CT-based radiomics features prediction status pediatric neuroblastoma via machine learning. A total 102 patients were retrospectively enrolled and divided into training (68 patients) validation sets (34 in a 2:1 ratio. Clinical characteristics extracted by XGBoost algorithm used...

Neuroblastoma is one of the most common types pediatric cancer. In current neuroblastoma prognosis, patients can be stratified into high- and low-risk groups. Generally, more than 90% in group will survive, while less 50% for those with high-risk disease survive. Since so-called "high-risk" still contain mixed good poor outcomes, refined stratification needs to established so that outcome, they receive prompt individualized treatment improve their long-term survival rate, outcome avoid...

Abstract Background Distal humerus fractures (DHFs) constitute one-third of elbow approximately. In this study, we aim to define and analyze the fracture lines morphological features DHFs using mapping technique. Methods One hundred two were retrospectively reviewed. All computed tomography (CT) data used manually reconstruct virtually reduce DHF fragments fit a standard 3D model. Smooth curves depicted accurately onto surface template represent lines. overlapped model create map heat map....

Abstract Background Although well accepted by clinicians and patients, teledentistry is not currently a widely used model of care within Australian public oral health services. This qualitative study aimed to review evaluate dental clinicians' perceptions, determining the acceptability appropriateness as care. Methods A purposive sample 12 practitioners employed Local Health District in Sydney, who had participated consultations, were recruited participate focus groups. Focus group...