A5101794021- Aldose Reductase and Taurine
- Signaling Pathways in Disease
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- Cardiac Structural Anomalies and Repair
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and biosynthesis
- Aortic Disease and Treatment Approaches
- Plant Gene Expression Analysis
- Chemotherapy-induced organ toxicity mitigation
- Alcohol Consumption and Health Effects
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Carcinogens and Genotoxicity Assessment
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Mitochondrial Function and Pathology
Beijing Union University
2006-2024
Hubei University of Technology
2024
First Affiliated Hospital of Xinxiang Medical University
2016-2023
Xinxiang Medical University
2016-2023
Sichuan Academy of Traditional Chinese Medicine
2023
T.K.M. College of Arts and Science
2013
Beijing Normal University
2011-2012
Oxidative stress has been proven to be involved in cisplatin (DDP)-induced toxicity. The aim of the present study was investigate a possible protective role grape seed proanthocyanidin extract (GSPE) DDP-induced spermiotoxicity. GSPE at 200 mg kg(-1) d(-1) and 400 orally administered for 15 consecutive days, starting 10 days before single intraperitoneal dose DDP (7 kg(-1)). Results revealed that testicular epididymal weight, sperm count, motility morphology, activities GSH-Px SOD, GSH...
Fatty liver disease (FLD) is mainly characterized by the pathophysiological progression from simple hepatic steatosis to steatohepatitis, which has been increasing in incidence and attracted much attention due its risk of hepatocellular carcinoma. It considered that lipid metabolism disorder, oxidative stress, inflammation etc. are common factors leading FLD including alcoholic fatty (AFLD) non-alcoholic (NAFLD). A number studies provide evidence taurine, a small sulfur-containing amino acid...
A number of studies indicate that taurine promotes cholesterol conversion to bile acids by upregulating CYP7A1 gene expression. Few in vitro are concerned the concentration change and its product acids, molecular mechanism induction taurine.The levels intracellular total (TC), free (FC), ester (EC), (TBA) medium TBA were determined after HepG2 cells cultured for 24/48 h DMEM supplemented with at final concentrations 1/10/20 mM respectively. The protein expressions CYP7A1, MEK1/2, c-Jun,...
Introduction Taurine has a prominent lipid-lowering effect on hyperlipidemia. However, comprehensive analysis of the effects taurine endogenous metabolites in hyperlipidemia not been documented. This study aimed to explore impact multiple associated with Methods The hyperlipidemic mouse model was induced by high-fat diet (HFD). administered via oral gavage at doses 700 mg/kg/day for 14 weeks. Evaluation body weight, serum lipid levels, and histopathology liver adipose tissue performed...
Postpartum depression (PPD), a severe mental health disorder, is closely associated with decreased gonadal hormone levels during the postpartum period. Mangiferin (MGF) possesses wide range of pharmacological activities, including anti-inflammation. Growing evidence has suggested that neuroinflammation involved in development depression. However, role MGF PPD largely unknown. In present study, by establishing hormone-simulated pregnancy mouse model, we found administration significantly...
Summary Myocardial ischaemia/reperfusion (I/R) injury may cause the apoptosis of cardiomyocytes as well mitochondrial dysfunction. The aims present study were to investigate whether NADH dehydrogenase 1 alpha subcomplex subunit 4‐like 2 ( NDUFA 4L2) on myocardial ischaemia‐reperfusion and underlying molecular mechanism. hypoxia‐reperfusion (H/R) model was established in vitro using H9c2 cells simulate I/R injury. 4L2 complex I expression levels detected RT ‐ PCR western blot. evaluated by...
Abstract The aim of this study was to evaluate the effect fruit and vegetable intake on gut microbiota using a mouse model metabolic syndrome (MS) induced by high‐fat diet. Forty‐eight male mice were randomly divided into four groups, control group (C), diet‐fed (H), high fat plus low fruits vegetables (H.LFV), (H.HFV), each fed for 60 days. During experiment, body weights recorded fecal samples collected. Cetyltrimethyl ammonium bromide (CTAB) method used extract bacterial DNA, purity...
Abstract Calcineurin is the only Ca 2+ /calmodulin‐dependent serine/threonine protein phosphatase. The roles of cytosolic calcineurin have been well researched; however, serum remain unknown. Here, we report that recombinant human B subunit (CnB) can bind to rabbit platelets and show an antiplatelet aggregation activity. Furthermore, CnB exerts anticoagulant effect by prolonging activated partial thromboplastin time thrombin reducing plasma fibrinogen concentration in a dose‐dependent...
Abstract Angelica dahurica (Fisch. ex Hoffm.) Benth.et Hook.f.var. formosana (Boiss.) Shan et Yuan ( A. ) is a well-known medicinal plant that has wide range of applications in the pharmaceutical, food, cosmetic, and other industries. However, issue early bolting emerged as major hindrance to its production. This problem not only reduces yield , but also an impact on active ingredients. To date, molecular factors contribute growth have been thoroughly investigated. Therefore, we conducted...
Obesity leads to severe health issues like cardiovascular disease. Natural substances with anti-obesity properties are gaining attention. This study investigates the impact of taurine on lipid levels in rats fed a high-fat diet.
Introduction: Sympathetic nervous system disorder promotes atrial fibrillation (AF), and neuropeptide Y (NPY) is an important neurotransmitter. This study aimed to explore the predictive value of plasma NPY in patients with AF. Methods: Five hundred seventy-six were divided into AF (including paroxysmal long-standing persistent AF; 360) sinus rhythm (SR) groups (216). level was detected using enzyme-linked immunosorbent assay, mRNA expression quantitative polymerase chain reaction. Logistic...
Abstract The effect of taurine on obese rats was studied. Methods: added to drinking water and given animals for 21 weeks. ATGL (adipose triglyceride lipase) inhibitor injected one week. results showed that could significantly reduce the body weight fat content rats, levels serum TG, TC LDL-C, increase level HDL-C, lipid deposition in liver aortic arch, decrease expression FAS (fatty acid synthase) ATGL. In addition, case intake, atglistatin (ATGL inhibitor) didn’t affect Conclusion: Taurine...