A5080164715- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- interferon and immune responses
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Particle physics theoretical and experimental studies
- Cardiac tumors and thrombi
- Cancer Genomics and Diagnostics
- Microbial Community Ecology and Physiology
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Computational Physics and Python Applications
- Animal Virus Infections Studies
- Cosmology and Gravitation Theories
- MicroRNA in disease regulation
- Dark Matter and Cosmic Phenomena
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Aldose Reductase and Taurine
- Environmental DNA in Biodiversity Studies
- Urinary and Genital Oncology Studies
Beijing Union University
2023-2024
Shenzhen University
2019-2024
China National Center for Food Safety Risk Assessment
2024
Shantou University
2021-2023
Shantou University Medical College
2021-2023
Shenzhen Luohu People's Hospital
2019-2023
Shenzhen Third People’s Hospital
2020-2023
University of Chicago
2023
Fermi National Accelerator Laboratory
2023
Institute of Hydrobiology
2012-2015
Abstract N6-Methyladenosine (m6A) is the most prevalent internal modification of mammalian mRNAs. Recent studies have shown that m6A methyltransferases METTL3 and METTL14 play important roles in urothelial bladder carcinoma (BLCA). To provide a more comprehensive understanding regulatory landscape cancer, we investigated role YTHDF2, crucial reader, BLCA. YTHDF2 was frequently upregulated at both RNA protein level Functionally, promoted proliferation tumor growth BLCA cells vitro vivo,...
Abstract Photodynamic therapy (PDT) by insertion of an optical fiber into the bladder cavity has been applied in clinic for noninvasive treatment tumors. To avoid systemic phototoxicity, intravesical instillation a photosensitizer may be ideal approach PDT cancer, comparison to conventional intravenous injection. However, instillation‐based cancer remains less effective due poor urothelial uptake photosensitizer, as well tumor hypoxia‐associated resistance. Herein, it is uncovered that...
Abstract Bladder cancer is one of the most common and highly vascularized cancers. To better understand its genomic structure underlying etiology, we conduct whole-genome targeted sequencing in urothelial bladder carcinomas (UBCs, type cancer). Recurrent mutations noncoding regions affecting gene regulatory elements structural variations (SVs) leading to disruptions are prevalent. Notably, find recurrent ADGRG6 enhancer FRS2 duplications which associated with higher protein expression tumor...
An essential goal of the Higgs physics program at LHC and beyond is to explore nature potential shed light on mechanism electroweak symmetry breaking.An important class models alter thermal history breaking from predictions Standard Model (SM).This paper reviews existence a region parameter space where strong first-order phase transition compatible with exotic decays SM-like boson.A dedicated search for can actively this framework Large Hadron Collider (LHC), while future decay searches...
The genome sequence, genetic characterization and nblA gene function of Microcystis aeruginosa myovirus isolated from Lake Dianchi in China (MaMV-DC) have been analysed. DNA is 169 223 bp long, with 170 predicted protein-coding genes ( 001L – 170L ) a tRNA gene. About one-sixth these homologues the host cyanobacteria M. . carries homologous to , which encodes protein involved degradation cyanobacterial phycobilisome. Its expression during MaMV-DC infection was confirmed by reverse...
Introduction Taurine has a prominent lipid-lowering effect on hyperlipidemia. However, comprehensive analysis of the effects taurine endogenous metabolites in hyperlipidemia not been documented. This study aimed to explore impact multiple associated with Methods The hyperlipidemic mouse model was induced by high-fat diet (HFD). administered via oral gavage at doses 700 mg/kg/day for 14 weeks. Evaluation body weight, serum lipid levels, and histopathology liver adipose tissue performed...
A bstract We investigate the electroweak phase transition patterns for a recently proposed baryogenesis model with CP violation originated in dark sector. The includes complex scalar singlet-Higgs boson portal, U(1) l gauge lepton symmetry Z ′ portal and fermionic matter particle. find novel thermal history of sector, featuring 2 breaking singlet vacuum early Universe driven by Yukawa coupling, that induces one-step strongly first order transition. explore parameter space generates observed...
Bladder cancer is one of the most common malignancy in urinary tract with high recurrence and drug resistance clinics. Alternative treatments from existing drugs might be a promising strategy. Nitazoxanide (NTZ), an FDA-approved antiprotozoal drug, has got increasingly noticed because its favorable safety profile antitumor potential, yet effects bladder underlying mechanisms remain poorly understood. Herein, we find that NTZ induces mitochondrial damage mitophagy initiation through...
Background The complete genome of Rana grylio virus (RGV) was sequenced and analyzed recently, which revealed that RGV 50L had homologues in many iridoviruses with different identities; however, the characteristics functions have not been studied yet. Methodology/Principal Findings We cloned characterized RGV50L, assembly gene regulation. encoded a 499-amino acid structural protein about 85 kDa molecular weight contained nuclear localization signal (NLS) helix- extension-helix motif. Drug...
Polo‐like kinase 4 (PLK4) has been reported to contribute tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate regulatory function BC progression. is overexpressed cell lines tissues, its overexpression correlated with poor prognosis. Our transcriptome analysis combined subsequent functional assays indicated that inhibition can suppress growth induce cycle arrest at G1 phase via activation p38/p53/p21 pathway...
Copy number variation (CNV) is a type of structural variation, which gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity CNVs are required realize relationship between these variants and clinical phenotypes. ClassifyCNV, X-CNV, StrVCTVRE, etc. have been trained CNVs, but few studies reported based on deleterious significance features.From single nucleotide polymorphism (SNP), gene region dimensions, we collected 79 informative features that...
Excision repair cross-complementation group 2 (ERCC2) encodes the DNA helicase xeroderma pigmentosum D, which functions in transcription and nucleotide excision repair. Point mutations ERCC2 are putative drivers around 10% of bladder cancers (BLCAs) a potential positive biomarker for cisplatin therapy response. Nevertheless, prognostic significance directly attributed to its pathogenic role genome instability remain poorly understood. We first demonstrated that mutant is an independent...
Abstract Background In bladder cancer, recurrent ADGRG6 enhancer hotspot mutations (chr. 6: 142,706,206 G>A, chr. 6:142,706,209 C>T) were reported at a high mutation rate of approximately 50%. Thus, status might be candidate for diagnostic biomarker. Methods To improve test efficacy, an amplification refractory system combined with quantitative real‐time PCR (ARMS‐qPCR) assay was developed to detect the in patient as clinical test. validate performance ARMS‐qPCR assay, artificial...
<h2>Abstract</h2> Taurine has been proven in many trials to alleviate the symptoms of metabolic associated fatty liver disease. Here its protective effect for hepatic steatosis and modulation AMP-activated protein kinase insulin signaling pathway were investigated. Steatotic HepG2 cell established with oleic acid (0.05 mmol/L), treated taurine (5 dorsomorphin (10 μmol/L) 24 h. Sprague Dawley rats divided into regular high-fat diet (HFD) groups, their corresponding (70 or 350 mg/kg BW/d) fed...
Citrin deficiency caused by SLC25A13 genetic mutations is an autosomal recessive disease, and four prevalent including c.851_854del, c.1638_1660dup, IVS6+5G&gt;A, IVS16ins3kb make up &gt;80% of total pathogenic within the Chinese population. However, suitable assays for detection these have not yet been developed use in routine clinical practice. In current study, a real-time PCR-based multicolor melting curve analysis (MMCA) was to detect one closed-tube reaction. The analytical...
Reliable high-throughput serological assays for SARS-CoV-2 antibodies present an important role in the strength and duration of immunity after vaccination. The study investigated analytical clinical performances neutralizing (NTAb) assay by chemiluminescent (CLIA), antibody vaccination real world.