A5101554084- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Histone Deacetylase Inhibitors Research
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- DNA Repair Mechanisms
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Immune cells in cancer
- Thyroid Cancer Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Cardiovascular Disease and Adiposity
- Chemokine receptors and signaling
- Circular RNAs in diseases
Shenzhen University
2022-2025
Wuhan Children's Hospital
2025
Huazhong University of Science and Technology
2025
University of Hong Kong
2019-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2023
Sun Yat-sen University
2019-2023
Sun Yat-sen University Cancer Center
2019-2023
Xiangnan University
2023
Xi'an Jiaotong University
2021
State Key Laboratory of Oncology in South China
2019-2020
The HOXA gene family is associated with various cancer types. However, the role of genes in acute myeloid leukemia (AML) have not been comprehensively studied. We compared transcriptional expression, survival data, and network analysis HOXA-associated signaling pathways patients AML using ONCOMINE, GEPIA, LinkedOmics, cBioPortal, Metascape databases. observed that HOXA2-10 mRNA expression levels were significantly upregulated high HOXA1-10 was poor patient prognosis. altered ~18% samples,...
The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 using scRNA-seq technology coupled a deep comprehensive analysis unique surface markers differentially expressed genes. We revealed (TRAV1-2 + CD8 )MAIT cells (NCAM1 hi CD160 )NK significantly enriched asymptomatic subjects whereas (LAG3 )NKT increased...
DNA mismatch repair is essential for protecting the human genome from damage induced by 5-methylcytosine deamination.
Cancer genomes with mutations in the exonuclease domain of Polymerase Epsilon (POLE) present an extraordinarily high somatic mutation burden. In vitro studies have shown that distinct POLE mutants exhibit different polymerase activity. Yet, genome-wide patterns and driver formation arising from remains unclear. Here, we curated calls 7,345 colorectal cancer samples published publicly available databases. These include 44 mutant including 9 whole genome sequencing data available. The were...
Accurate prediction of survival in patients with acute myelogenous leukemia (AML) is challenging. Therefore, we developed a predictive model using endocrine-related gene expression to identify an endocrine signature for accurate stratification AML prognosis. RNA matrices and clinical data were downloaded from training dataset (GEO) two validation datasets (TCGA TARGET). In relation the outcome, risk was constructed by incorporating seven genes. The exhibited favorable efficacy estimating...
Abstract Background: In contemporary oncopharmacology, antigenic targets remain a pivotal focus, especially within the realm of immunotherapy, where tumor-specific antigens are critical importance. Extensive research on these has spurred development innovative therapeutic modalities, such as antibody therapies, CAR-T/NK cell XDC conjugate drug tumor neoantigen and gene therapies. However, strategies encounter significant challenges related to antigen target specificity. Although engineered...
MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel that were identified 233 plasma samples 61 healthy controls 116 patients COVID-19 using the high-throughput sequencing computational analysis. These DE-miRNAs associated SASR-CoV-2 infection, disease severity, persistence COVID-19, respectively....
Acute myeloid leukemia (AML) is a type of cancer that consists group hematological malignancies with high heterogeneity. DNA methyltransferase 3A (DNMT3A)-mutated AML patients have poor prognosis. Some long non-coding RNAs (lncRNAs) been reported to enhance therapeutic sensitivity, and so could affect the overall survival rate elderly cytogenetically normal acute (CN-AML) patients; however, studies on lncRNA signature in DNMT3A-mutated are rare.The DNMT3A R878H conditional knock-in mouse...
Excision repair cross-complementation group 2 (ERCC2) encodes the DNA helicase xeroderma pigmentosum D, which functions in transcription and nucleotide excision repair. Point mutations ERCC2 are putative drivers around 10% of bladder cancers (BLCAs) a potential positive biomarker for cisplatin therapy response. Nevertheless, prognostic significance directly attributed to its pathogenic role genome instability remain poorly understood. We first demonstrated that mutant is an independent...
AGINGAdenylyl cyclases (ADCYs) have been attracting increased attention in recent years [4].These enzymes, which catalyze the generation of cAMP from ATP [5,6], differ their responses to upstream regulatory pathways and distribution, play essential roles learning, synaptic plasticity, cardiovascular tumorigenesis [7][8][9][10].The nine members ADCY family (ADCY1-ADCY9) exhibit distinct G protein coupled receptors grouped into three subgroups based on functional activities sequence...
As suggested by an increasing amount of evidence, there is alternative splicing (AS) modification within malignancy, which related to cancer occurrence and development. AS acute myeloid leukemia (AML) has not yet been systematically analyzed yet. This study the transcriptomic profiling corresponding clinical data from AML cases based on The Cancer Genome Atlas (TCGA). In addition, prediction model, along with network, was used analyze prognosis for patients according seven different event...
Abstract Myelodysplastic syndrome (MDS) is clonal disease featured by ineffective haematopoiesis and potential progression into acute myeloid leukaemia (AML). At present, the risk stratification prognosis of MDS need to be further optimized. A prognostic model was constructed least absolute shrinkage selection operator (LASSO) regression analysis for patients based on identified metabolic gene panel in training cohort, followed external validation an independent cohort. The with lower had...
Abstract DNA mismatch repair (MMR) is essential for maintaining genome integrity with its deficiency predisposing to cancer 1 . MMR well known role in the post-replicative of mismatched base pairs that escape proofreading by polymerases following cell division 2 Yet, sequencing has revealed deficient cancers not only have high mutation burden but also harbour multiple mutational signatures 3 , suggesting pleotropic effects on repair. The mechanisms underlying these remained unclear despite...
Abstract Oncolytic viruses have elucidated the broad anti-tumor properties through selectively destroying tumor cells, promoting antigen release and inducing activation of immune response. Vaccinia virus (VV) has been engineered for selectivity by deletion two essential genes (DDvv), viral growth factor (VGF) thymidine kinase (TK). However, it still certain obstacles, such as spread virus, microenvironment barrier, cell infiltration lymphocytes (TILs) proliferation. In present study, we...