A5100630549- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Infant Nutrition and Health
- Textile materials and evaluations
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Digestive system and related health
- Proteoglycans and glycosaminoglycans research
- Computational Drug Discovery Methods
- Food Quality and Safety Studies
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Caveolin-1 and cellular processes
- Vitamin C and Antioxidants Research
- Autophagy in Disease and Therapy
- Helicobacter pylori-related gastroenterology studies
- Molecular Sensors and Ion Detection
- Protein Tyrosine Phosphatases
- Histone Deacetylase Inhibitors Research
- Bioactive natural compounds
- NF-κB Signaling Pathways
- Curcumin's Biomedical Applications
Shanghai Academy of Agricultural Sciences
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2008-2024
Zhengzhou University
2011-2024
Henan University
2024
Shanghai Institute of Technology
2024
Ministry of Education of the People's Republic of China
2022-2024
Second Military Medical University
2024
Huazhong Agricultural University
2021-2023
First Affiliated Hospital of Zhengzhou University
2015-2021
Hebei General Hospital
2017
Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may associated with the proliferation metastasis of GC. It reported that LSD1 repressed tumor immunity through programmed cell death ligand (PD-L1) melanoma breast cancer. The role immune microenvironment GC is unknown.Expression PD-L1 patients was analyzed by immunohistochemical (IHC) Western blotting. Exosomes were isolated from culture medium cells using an...
Taxifolin is a natural antioxidant polyphenol with various bioactivities and has many beneficial effects on human gut health. However, little known of its function colitis. In this study, the protective taxifolin colitis symptoms, inflammation, signaling pathways, colon microbiota were investigated using dextran sulfate sodium (DSS)-induced mice. Intriguingly, pre-administration alleviated symptoms histological changes DSS-challenged Supplementation significantly inhibited secretions tumor...
Lung cancer, a commonly diagnosed malignancy, is the leading cause of cancer-related death worldwide. Aspirin suppresses progression and metastasis various cancers. However, effect aspirin on non-small cell lung cancer (NSCLC) has not been fully understood. It established that glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) CD36 play vital role in lipid metabolism transport. This study aimed to clarify mechanism by which inhibits NSCLC proliferation via GPIHBP1. The blood...
Inflammatory bowel disease (IBD) is a chronic intestinal disorder threatening human health. Di-peptide alanyl-glutamine (Ala-Gln) has various beneficial effects on gut However, its role and functional mechanism in treating IBD are still not clear. Therefore, the protective of Ala-Gln glutamine (Gln) dextran sulfate sodium- (DSS-) induced colitic mice were investigated this study. The results showed that oral supplementation or Gln significantly attenuated colitis symptoms mice, including...
Although molecular data have revealed huge amounts of plant diversity, interpreting genetic diversity into entities corresponding to species is still challenging. Taxonomic ranking based on distance has been used extensively, but the results open dispute, while application strategy plants restricted a small number cases. Here, levels internal transcribed spacer 2 (ITS2) sequence variation were examined from 17,203 sequences, representing 5,439 in 113 genera seed plants, ascertain association...
A number of studies indicate that taurine promotes cholesterol conversion to bile acids by upregulating CYP7A1 gene expression. Few in vitro are concerned the concentration change and its product acids, molecular mechanism induction taurine.The levels intracellular total (TC), free (FC), ester (EC), (TBA) medium TBA were determined after HepG2 cells cultured for 24/48 h DMEM supplemented with at final concentrations 1/10/20 mM respectively. The protein expressions CYP7A1, MEK1/2, c-Jun,...
Long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) are essential for the progression of tumors, including cutaneous squamous cell carcinoma (CSCC). The present study aimed to examine competing endogenous RNA (ceRNA) network in CSCC. Differentially expressed genes CSCC were analyzed using GSE66359 microarray data set, upstream miRNAs lncRNAs predicted online database analysis (TargetScan 7.1, mirDIP 4.1, miRSearch V3.0, miRDB RNA22 2.0) verified clinical tissues. pull‑down dual luciferase...
The overexpression of inducible nitric oxide synthase (iNOS) induces cell apoptosis through various signal transduction pathways and aggravates lung injury. Caspase‑3 is an important protein in the apoptotic pathway its activation can exacerbate apoptosis. Simvastatin, a hydroxymethyl glutaryl‑A reductase inhibitor, protects against smoke inhalation injury by inhibiting synthesis release inflammatory factors decreasing Following establishment animal model injury, tissue serum were collected...
Abstract Plasma circulating P‐selectin glycoprotein ligand‐1 (PSGL‐1) levels and its clinical correlation in patients with epithelial ovarian cancer (EOC) are unknown. The study determined plasma PSGL‐1 EOC investigated relationship clinicopathological factors prognosis. were measured using ELISA 69 EOC, 34 benign cystadenoma, 36 healthy controls. Subsequently, the between characteristics of patients, as well prognosis was examined. Additionally, specificity sensitivity assessed through ROC...
New Findings What is the central question of this study? Long non‐coding RNAs (lncRNAs) are widely involved in progression Hirschsprung's disease (HSCR), but role actin filament associated protein 1 antisense RNA1 ( AFAP1‐AS1 ), an lncRNA, HSCR has not been explored before. main finding and its importance? Downregulation blocks enteric neural crest stem cell proliferation, differentiation, migration invasion promotes occurrence via miR‐195/E2F3 axis, indicating that AFAP1‐AS might be a...
Neuroblastoma, a malignant tumor of the sympathetic nervous system, is an aggressive extracranial in childhood. Long noncoding RNAs (lncRNAs) have been discovered to play key role eukaryotic regulatory gene network and be involved wide variety biological processes. We observed that expression lncRNA nuclear-enriched abundant transcript-1 (NEAT1) was significantly decreased human neuroblastoma tissues cell lines, compared with normal. proliferation, migration, invasion Cell Counting Kit-8...
A well-known milk-derived bioactive tripeptide, VPP (Val-Pro-Pro) has good anti-inflammatory, anti-hypertension, and anti-hydrolysis properties. However, whether can alleviate calf intestinal inflammation is unclear. In this experiment, the effects of on growth, diarrhea incidence, serum biochemical indices, short-chain fatty acids, fecal microorganisms were examined in pre-weaning Holstein calves. Eighteen calves with similar birth date, body weight, genetic background randomly assigned...
Discussed the protection of taxane-derived compounds, 7-deacetyl-taxine B and 5-cinnamoyloxy-taxin B, against oxidative stress injury.SK-N-SH cells were pretreated with or DMSO (control) then incubated H2O2 for another 24 h. Cell viability was measured by MTT colorimetric assay. Apoptosis rate, reactive oxygen species (ROS) mitochondrial membrane potential (MMP) detected using flow cytometry Ultrastructure Transmission electron microscope.Taxane-derived compounds improved mediated loss cell...
Dual-specificity phosphatase 12 (DUSP12) is abnormally expressed under various pathological conditions and plays a crucial role in the progression of disorders. However, DUSP12 cerebral ischaemia/reperfusion injury has not yet been investigated. This study explored possible link between using an oxygen-glucose deprivation/reoxygenation (OGD/R) model. Marked decreases levels have observed cultured neurons exposed to OGD/R. DUSP12-overexpressed were resistant OGD/R-induced apoptosis...
Esophageal squamous cell carcinoma (ESCC) is one of the most common forms malignancy worldwide. However, there currently a lack effective chemotherapeutic drugs for ESCC. Ivermectin broad-spectrum antiparasitic drug with notable antitumor activity. cellular and molecular mechanisms by which ivermectin inhibits cancer growth remain unclear. In this study, we elucidate role in ESCC suppression activating endoplasmic reticulum (ER) stress autophagy pathways. transcriptome analyses, find that...