A5018813176- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Nanoplatforms for cancer theranostics
- Transition Metal Oxide Nanomaterials
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Ga2O3 and related materials
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
Weifang Medical University
2016-2025
St. John's University
2014-2023
Weifang University
2019
Harvard University
2011
Sun Yat-sen University
2002-2007
Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may associated with the proliferation metastasis of GC. It reported that LSD1 repressed tumor immunity through programmed cell death ligand (PD-L1) melanoma breast cancer. The role immune microenvironment GC is unknown.Expression PD-L1 patients was analyzed by immunohistochemical (IHC) Western blotting. Exosomes were isolated from culture medium cells using an...
Abstract Multi‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic (PDT) promising modality that can circumvent MDR and synergize with chemotherapies, based on the generation reactive oxygen species (ROS) by photosensitizers. However, overproduction glutathione (GSH) cells scavenges ROS restricts efficacy PDT. Additionally, side effects normal tissues are unavoidable after PDT treatment. Here, to develop organic systems deliver effective anticancer chemotherapy...
As one of the most promising means to repair diseased tissues, stem cell therapy with immense potential differentiate into mature specialized cells has been rapidly developed. However, clinical application stem-cell-dominated regenerative medicine was heavily hindered by loss pluripotency during long-term in vitro expansion. Here, a composite three-dimensional (3D) graphene-based biomaterial, denoted as GO-Por-CMP@CaP, hierarchical pore structure (micro- macropore), developed guide...
Nilotinib and dasatinib have not been directly compared in a randomized trial for the treatment of newly diagnosed chronic myeloid leukemia phase (CML-CP). The purpose this study was to indirectly compare rates major molecular response (MMR), progression-free survival (PFS) overall by month 12 with nilotinib CML-CP.Individual patient data from vs. imatinib (ENESTnd) published summary separate (DASISION) were utilized. A matching-adjusted indirect comparison conducted weighting individual...
Histone demethylases are promising therapeutic targets as they play fundamental roles for survival of Mixed lineage leukemia rearranged acute ( MLL r AL). Here we focused on the catalytic Jumonji domain histone H3 lysine 9 (H3K9) demethylase JMJD1C to screen potential small molecular modulators from 149,519 natural products and 33,765 Chinese medicine components via virtual screening. inhibitor 4 (JDI‐4) JDI‐12 that share a common structural backbone were detected within top 15 compounds....
// Rishil J. Kathawala 1,8,* , Liuya Wei 1,2,* Nagaraju Anreddy 1 Kang Chen 3,4,5,6 Atish Patel Saeed Alqahtani 7 Yun-Kai Zhang Yi-Jun Wang Kamlesh Sodani Amal Kaddoumi Charles R. Ashby Jr. and Zhe-Sheng Department of Pharmaceutical Sciences, College Pharmacy Health St. John’s University, Queens, NY, USA 2 School Biological Weifang Medical Weifang, People’s Republic China 3 Obstetrics Gynecology, Wayne State University Medicine, Detroit, Michigan, 4 Perinatology Research Branch,...
The purpose of this study was to characterize the polysaccharides from Athyrium multidentatum (Doll.) Ching (AMC) rhizome and explore protective mechanism against d-galactose-induced oxidative stress in aging mice.A series experiments, including molecular weight, monosaccharide composition, Fourier transform infrared (FT-IR) spectroscopy, 1H nuclear magnetic resonance (1H NMR) spectroscopy were carried out AMC polysaccharides. investigated exploring mouse model. Quantitative real-time...
Herein, we explore a new carbon source for preparation of quantum dots (CQDs) with controllable composition using porous organic polymer (POP) derived via nitric acid oxidation method. The POP used the CQDs was synthesized by mechanochemical Friedel-Crafts alkylation under solvent free conditions. Using as-prepared CQDs, develop simple and effective electrochemiluminescence (ECL) detection method dopamine (DA) CQD/chitosan-graphene composite modified glassy electrode (GCE). Both...
In discovery of novel SIRT3 inhibitors for the treatment cancer, a series 2-(4-acrylamidophenyl)-quinoline-4-carboxylic acid derivatives were designed and synthesized. Among derived compounds, molecule P6 exhibited inhibitory selectivity with IC50 value 7.2 µM over SIRT1 (32.6 µM) SIRT2 (33.5 µM). molecular docking analysis revealed specific binding pattern in active site compared bindings SIRT2. antiproliferative colony forming assay, showed potent activity against group MLLr leukemic cell...
The emergence of infections caused by bacterial pathogens that are resistant to current antibiotic therapy is a critical healthcare challenge. Aminoglycosides natural antibiotics with broad spectrum activity; however, their clinical use limited due considerable nephrotoxicity. Moreover, drug-resistant bacteria cause in human as well livestock less responsive conventional antibiotics. Herein, we report the vitro antibacterial evaluation five different aminoglycosides, including ribostamycin,...
Acute leukemia (AL) is characterized by excessive proliferation and impaired differentiation of leukemic cells. AL includes acute myeloid (AML) lymphoblastic (ALL). Previous studies have demonstrated that about 10% AML 22% ALL are mixed lineage gene rearrangements (MLLr) leukemia. The prognosis MLLr poor new therapeutics urgently needed. Differentiation therapy with all-trans-retinoic acid (ATRA) has prolonged the 5-years disease-free survival rate in promyelocytic (APL), a subtype AML....