A5101960679- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Advanced Biosensing Techniques and Applications
- Viral-associated cancers and disorders
- HER2/EGFR in Cancer Research
- Protease and Inhibitor Mechanisms
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Adipose Tissue and Metabolism
- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Galectins and Cancer Biology
- Medical Research and Treatments
Union Hospital
2024
Jilin University
2023-2024
First Affiliated Hospital of Hebei Medical University
2023-2024
Hebei Medical University
2023-2024
Hospital of Hebei Province
2023
Union Hospital
2023
Kunming Medical University
2022
Peking University
2013-2022
Peking University Cancer Hospital
2013-2022
Weifang Medical University
2020
Hodgkin disease (HD) is characterized by a small number of putative malignant cells [Hodgkin and Reed-Sternberg (HRS) cells] among background lymphocytes histiocytes. The lineage HRS still elusive clonal origin these rare has not formally been demonstrated. We isolated micromanipulation from histological sections three cases lymphoma (each representing distinct subtype the disease) analyzed individual for immunoglobulin variable (V) gene rearrangements PCR. In each single heavy-chain V (VH)...
To assess the changes in body composition and nutritional risks faced by children with different stages of acute leukemia (AL). Bioelectrical impedance analysis combined anthropometric measurements was used to detect composition. This prospective study conducted from August 2023 July 2024 at Shandong Provincial Hospital, examining physical balance various AL healthy children. The non-fat components both showed a linear increase age. In younger age group, there were no significant differences...
Special AT-rich sequence-binding protein-1 (SATB1) has been identified as a genome organizer that reprograms chromatin organization and transcription profiles. SATB1 promotes tumor growth metastasis in breast cancer is associated with poor prognosis several types. The association between colorectal (CRC) not studied intensively. Therefore, this study aimed to investigate the effect of on CRC vitro vivo its correlation overall survival clinicopathological factors patients. Stable knockdown...
Abstract Retroperitoneal liposarcoma ( RLPS ) is one of the most common subtypes retroperitoneal soft tissue sarcomas and lacks effective treatment. This study aimed to provide a thorough profile immune characteristics . included 56 patients. Multisite tumor tissues were collected from 16 Immunohistochemistry was carried out identify CD 4 + , 8 FoxP3 20 or programmed cell death‐1 PD ‐1) infiltrating lymphocytes TIL s) Programmed death ligand‐1 ‐L1) expression in tissues. Ultradeep sequencing...
Considering the indication of adjuvant therapy, recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current stratification schemes may still have room improvement. This study seeks analyze prognostic factors GISTs from 3 aspects, including clinicopathological parameters, immunohistochemical biomarkers, and gene mutational status, attempts find novel valuable predicting malignancy potential GISTs.Retrospective data 114...
This study aimed to investigate the expression of CD147 and MMP-11 in human colorectal cancer (CRC) evaluate their clinical significance. Real-time polymerase chain reaction was used mRNA level 56 pairs fresh CRC samples matched with adjacent normal mucosa. The protein specimens corresponding mucosa were evaluated by immunohistochemistry on tissue microarrays. Expression co-localization these two proteins also laser scanning confocal microscopy. Furthermore, correlations clinicopathological...
Colorectal cancer (CRC) has one of the highest mortality rates in worldwide and its incidence been increasing recent years. Protein tyrosine kinase-7 (PTK7) is an inactive member receptor protein kinase (RPTK)-like molecules, which involved tumorigenesis a variety cancers. Our study aimed to investigate expression PTK7 colorectal tumors (including benign adenomas malignant carcinomas), potential function prognosis. A total 209 CRC patients 28 colonic adenoma were included this study. Reverse...
This study sought to evaluate the infiltration tendency of retroperitoneal liposarcoma (RPLS) from a new pathological angle by exploring characteristics, which could provide helpful information facilitate surgical decision-making and prognosis prediction. Concurrently, we aim identify significant indicators infiltration. A total 61 consecutive patients with RPLS at our institution were retrospectively analyzed. All received extended surgery. The tumor characteristics influencing factors...
Rationale . To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. analyze predictive histological grade main prognostic factors. Methods 195 patients with 44 diseases have been included. Relationship between SUVmax, Clinical, pathological, information has analyzed. Results Malignant tumors do not show higher SUVmax than benign ones (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Gastric cancer (GC) is one of the most frequent malignant tumors. In order to systematically characterize cellular and molecular mechanisms intestinal GC development, in this study, we used 22 K oligonucleotide microarrays bioinformatics analysis evaluate gene expression profiles 45 tissue samples, including 20 normal appearing tissues (NATs) adjacent tumors 5 noncancerous gastric mucosa samples. These allowed us explore transcriptional characteristics determine change patterns that...
Pancreatic cancer is lethal due to lack of perceptible symptoms and effective treatment methods. Immunotherapy may provide promising therapeutic choices for malignant tumors like pancreatic cancer. Tumor‐infiltrating lymphocytes ( TIL ) in tumor mesenchyme could recognize peptide antigens presented on the surface cells. The present study aimed test relationship between T cell receptor TCR β repertoire peripheral blood, also investigate intra‐tumor spatial heterogeneity To best our knowledge,...
Our previous study has suggested thatthe bladder cancer-associated protein gene (BLCAP) was among the differentially expressed genes in cervical cancer. We confirm here that BLCAP is all noncancerous tissues (10/10), but it greatly lost primary cancer tissue (31/39). In order to further investigate functional roles of BLCAP, we stably transfected cDNA into HeLa cells. The cells expressing show reduced cell growth and clone genicity compared vector-transfected cognate expression leads arrest...
Chronic myeloid leukemia (CML) is caused by the Philadelphia (Ph+) chromosome carrying BCR-ABL oncogene, a constitutively active tyrosine kinase. The discovery of imatinib represents major success story in treatment against CML. However, mutations kinase domain are cause resistance to imatinib, demonstrating that remains critical drug target. Here, we investigate novel small molecule inhibitor, OGP46, for its inhibitory activity K562, panel murine BaF3 cell lines stably expressing either...
A 46-year-old woman underwent surgery for parathyroid carcinoma 2 years ago. During follow-up, the patient presented with elevated hormone (127.50 pg/mL; normal, 15-65). No abnormal uptake of 18 F-FDG or 11 C-choline was observed on and PET/CT imaging. The enrolled in a clinical trial F-FAPI imaging, revealing lesion intense focal within left sternocleidomastoid muscle. surgery. Postoperative pathology immunohistochemical analysis confirmed metastasis.