A5083341221- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Surface Modification and Superhydrophobicity
- Circular RNAs in diseases
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Protease and Inhibitor Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Anorectal Disease Treatments and Outcomes
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Environmental and Agricultural Sciences
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
Shanxi Medical University
2019-2025
First Hospital of Shanxi Medical University
2020-2025
Peking University
2015-2024
Peking University Cancer Hospital
2015-2024
Guizhou University
2024
Zunyi Medical University
2014
China Institute of Water Resources and Hydropower Research
2014
Exosomes can be efficiently isolated in a short period of time by the specific interaction titanium dioxide with phosphate groups on surface phospholipid bilayer.
Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy circular RNAs (circRNAs) play critical roles cancer progression chemoresistance. However, function mechanism of circRNA autophagy regulation LSCC remain unclear. The autophagy-suppressive circPARD3 was identified via RNA sequencing 107 tissues paired adjacent normal mucosal (ANM) high-content screening. RT-PCR, Sanger sequencing, qPCR fluorescence situ hybridization were performed...
Introduction: Network pharmacology has emerged as a forefront and hotspot in anti-cancer. Traditional anti-cancer drugs are limited by the paradigm of "one cancer, one target, drug," making it difficult to address challenges recurrence drug resistance. However, main advantage network lies its approach from perspective molecular relationships, employing arrow, multiple targets" strategy, which provides novel pathway for developing drugs. This study employed bibliometric analysis method...
Background: Colorectal cancer (CRC) is one of the most prevalent gastrointestinal malignancies. The incidence CRC has been rapidly increasing in China. Transferrin receptor 1 (TfR1) a key regulator cellular iron homeostasis. Several studies have demonstrated TfR1 overexpression variety human tumors, but association between and remains unclear. Methods: expression was evaluated six cell lines tumor tissues. A total 201 patients were included for immunohistochemistry 19 pairs frozen tissues...
Head and neck squamous cell carcinoma (HNSCC), a highly invasive malignancy with poor prognosis, is one of the most common cancers globally. Circular RNAs (circRNAs) have become key regulators human malignancies, but further studies are necessary to fully understand their functions possible causes in HNSCC. CircCCT2 expression levels HNSCC tissues cells were measured via qPCR. was characterized by Sanger sequencing, qRT-PCR, RNase R & Actinomycin D treatment, nucleoplasmic separation FISH...
As the population ages, problems pertaining to health and life expectancy due aging heart have become increasingly prominent. The gut microbiota has a potential therapeutic target in several diseases, including cardiovascular diseases. Current studies on roles of system focused mainly diseases; therefore, effects natural myocardial tissue remain unclear. present study aimed explore mechanisms related metabolites heart. Animal models fecal transplantation (FMT) were established elderly young...
Special AT-rich sequence-binding protein-1 (SATB1) has been identified as a genome organizer that reprograms chromatin organization and transcription profiles. SATB1 promotes tumor growth metastasis in breast cancer is associated with poor prognosis several types. The association between colorectal (CRC) not studied intensively. Therefore, this study aimed to investigate the effect of on CRC vitro vivo its correlation overall survival clinicopathological factors patients. Stable knockdown...
Abstract Retroperitoneal liposarcoma ( RLPS ) is one of the most common subtypes retroperitoneal soft tissue sarcomas and lacks effective treatment. This study aimed to provide a thorough profile immune characteristics . included 56 patients. Multisite tumor tissues were collected from 16 Immunohistochemistry was carried out identify CD 4 + , 8 FoxP3 20 or programmed cell death‐1 PD ‐1) infiltrating lymphocytes TIL s) Programmed death ligand‐1 ‐L1) expression in tissues. Ultradeep sequencing...
Considering the indication of adjuvant therapy, recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current stratification schemes may still have room improvement. This study seeks analyze prognostic factors GISTs from 3 aspects, including clinicopathological parameters, immunohistochemical biomarkers, and gene mutational status, attempts find novel valuable predicting malignancy potential GISTs.Retrospective data 114...
This study aimed to investigate the expression of CD147 and MMP-11 in human colorectal cancer (CRC) evaluate their clinical significance. Real-time polymerase chain reaction was used mRNA level 56 pairs fresh CRC samples matched with adjacent normal mucosa. The protein specimens corresponding mucosa were evaluated by immunohistochemistry on tissue microarrays. Expression co-localization these two proteins also laser scanning confocal microscopy. Furthermore, correlations clinicopathological...
Colorectal cancer (CRC) has one of the highest mortality rates in worldwide and its incidence been increasing recent years. Protein tyrosine kinase-7 (PTK7) is an inactive member receptor protein kinase (RPTK)-like molecules, which involved tumorigenesis a variety cancers. Our study aimed to investigate expression PTK7 colorectal tumors (including benign adenomas malignant carcinomas), potential function prognosis. A total 209 CRC patients 28 colonic adenoma were included this study. Reverse...
Pancreatic ductal adenocarcinoma (PDAC) is one of the highest fatality rate cancers with poor survival rates. The tumor microenvironment (TME) vital for immune responses, leading to resistance chemotherapy and prognosis PDAC patients. This study aimed provide a comprehensive evaluation genes in that might help predicting guiding clinical treatments.
Head and neck cancer is one of the most common tumors worldwide. However, drug resistance in its treatment has become a major factor limiting efficacy. This study aims to comprehensively understand current status research this field. The analyzes papers related therapeutic head published between 2000 2023 Web Science Core Collection To achieve objectives, we searched WoSCC for review on from 2023, screened English literature, analyzed hotspots, academic collaborations, trends detail using...
Patient-derived xenograft (PDX) models are effective preclinical cancer that reproduce the tumor microenvironment of human body.The methods have been widely used for drug screening, biomarker development, co-clinical trials, and personalized medicine.However, low success rate long tumorigenesis period largely limited their usage.In present studies, we compared PDX establishment between hepatocellular (HCC) metastatic liver (MLC), identified key factors affecting transplantation...
Retroperitoneal liposarcoma (RLPS) is the most common subtype of retroperitoneal soft tissue sarcoma, characterized by a high recurrence rate and insensitivity to radiotherapy chemotherapy.The function tumor microenvironmental components, especially tumor-associated fibroblasts (TAFs), remains unclear in RLPS.The crosstalk between cells stromal should be clarified for therapy target discovery RLPS.In this study, we demonstrated that TAFs from dedifferentiated (DDLPS) could attract LPS...
Pancreatic cancer is lethal due to lack of perceptible symptoms and effective treatment methods. Immunotherapy may provide promising therapeutic choices for malignant tumors like pancreatic cancer. Tumor‐infiltrating lymphocytes ( TIL ) in tumor mesenchyme could recognize peptide antigens presented on the surface cells. The present study aimed test relationship between T cell receptor TCR β repertoire peripheral blood, also investigate intra‐tumor spatial heterogeneity To best our knowledge,...
Background: In western patients, the association of Fusobacterium nucleatum (F. nucleatum) with colorectal carcinoma (CRC) has been established, but underlying mechanism remains unclear. There is no report about F. infection status and its potential role in CRC patients China. This study aimed to evaluate load correlation clinicopathological features prognosis China.Methods: Fresh tumor adjacent normal mucosa tissues were obtained at surgery from 152 then DNA was assayed for by quantitative...