A5101495159- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Cardiac tumors and thrombi
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Vascular Tumors and Angiosarcomas
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Neurofibromatosis and Schwannoma Cases
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Inflammatory Biomarkers in Disease Prognosis
- Intraperitoneal and Appendiceal Malignancies
- Lymphoma Diagnosis and Treatment
- Advanced Sensor and Energy Harvesting Materials
- Liver Disease Diagnosis and Treatment
Peking University
2015-2024
Peking University Cancer Hospital
2014-2024
Chinese PLA General Hospital
2024
First Affiliated Hospital of Guangzhou Medical University
2021-2023
State Key Laboratory of Respiratory Disease
2021-2023
Guangzhou Medical University
2021-2023
Tianjin First Center Hospital
2014-2021
Tianjin Medical University
2014-2021
Stanford University
2021
Shenzhen University
2019
Checkpoint inhibitor-related pneumonitis (CIP) is a potentially fatal immune-related adverse event that occurs during treatment with immune checkpoint inhibitors (ICIs). However, the roles played by peripheral blood parameters in CIP development remain unclear. Here, we aimed to identify which biomarkers correlated and prognosis of patients lung cancer.We conducted retrospective analysis 87 (CIP group) without (control group). Cytokines, routine, lactate dehydrogenase (LDH) albumin (ALB)...
Abstract Retroperitoneal liposarcoma ( RLPS ) is one of the most common subtypes retroperitoneal soft tissue sarcomas and lacks effective treatment. This study aimed to provide a thorough profile immune characteristics . included 56 patients. Multisite tumor tissues were collected from 16 Immunohistochemistry was carried out identify CD 4 + , 8 FoxP3 20 or programmed cell death‐1 PD ‐1) infiltrating lymphocytes TIL s) Programmed death ligand‐1 ‐L1) expression in tissues. Ultradeep sequencing...
Background and Objective Immune checkpoint inhibitor (ICI)-associated myocarditis is a fatal immune-related adverse events (irAEs), which prone to affecting multiple organ systems. Multi-organ irAEs have not been fully studied in ICI-associated myocarditis. Therefore, we aimed explore the impact of multi-organ on ICI terms clinical features, treatment, prognosis. Methods This was retrospective study. The data patients were collected from 6 hospitals China. risk factors characteristics pure...
BACKGROUD: Carcinoma of the right colon invading pancreas or duodenum is rare. Evidence indication, operative morbidity, and survival en bloc pancreaticoduodenectomy colectomy for cancer adjacent organs limited. OBJECTIVE: The goal this study was to investigate feasibility, safety, long-term results in treatment locally advanced right-sided cancer. DESIGN: This a retrospective analysis all inpatients undergoing colectomy. Detailed data these patients were assessed by thorough review medical...
Pancreatic ductal adenocarcinoma (PDAC) is one of the highest fatality rate cancers with poor survival rates. The tumor microenvironment (TME) vital for immune responses, leading to resistance chemotherapy and prognosis PDAC patients. This study aimed provide a comprehensive evaluation genes in that might help predicting guiding clinical treatments.
Background Rearranged during transfection (RET) fusion is a kind of uncommon mutation (about 1%) in non-small cell lung cancer (NSCLC). Although selective tyrosine kinase inhibitors (TKI) (selpercatinib and pralsetinib) have been available, there are no real-world data about the difference efficacy between RET-TKI other regimens China. Methods We conducted multicenter retrospective analysis 49 patients with RET-fusion-positive NSCLC. The characteristics clinical outcomes RET-TKI,...
This study aims to analyze the postsurgical health-related quality of life (HRQOL) and voice (QOV) patients with laryngeal carcinoma an expectation improving treatment HRQOL these patients. Based on collection information regarding clinical characteristics (age, TNM stage, or without preservation and/or neck dissection, postoperative irradiation chemotherapy, etc.), QOV using Voice Handicap Index (VIH) scale EORTC QLQ-C30 EORTCQLQ-H&N35 scales, differences related their were analyzed...
Abstract Purpose: This phase II, multicenter, prospective, single-arm study aimed to evaluate the efficacy and safety of toripalimab plus bevacizumab for treating advanced hepatocellular carcinoma (HCC). Patients Methods: Treatment-naïve patients with HCC received 240 mg 15 mg/kg every 3 weeks. The primary endpoints included tolerability objective response rate (ORR) assessed by investigator per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Results: Fifty-four were...
Extended surgery with multi-visceral resection is the standard treatment for retroperitoneal liposarcoma (RLPS). Malnutrition tends to result in increased surgical complications and reduced survival. The aim of this study was identify prognostic role nutritional status patients RLPS.
<b><i>Aims:</i></b> To compare the short- and long-term outcomes in patients with pancreatic benign or borderline neoplasm who underwent central pancreatectomy (CP) distal (DP). <b><i>Methods:</i></b> The inclusion criteria were as follows: (1) single low-grade malignant tumor; (2) tumor confined to neck proximal body; (3) amenable either CP DP. Short outcomes, including complications, exocrine endocrine function, quality of life (QoL) analyzed...
This study sought to evaluate the infiltration tendency of retroperitoneal liposarcoma (RPLS) from a new pathological angle by exploring characteristics, which could provide helpful information facilitate surgical decision-making and prognosis prediction. Concurrently, we aim identify significant indicators infiltration. A total 61 consecutive patients with RPLS at our institution were retrospectively analyzed. All received extended surgery. The tumor characteristics influencing factors...
Patient-derived xenograft (PDX) models are effective preclinical cancer that reproduce the tumor microenvironment of human body.The methods have been widely used for drug screening, biomarker development, co-clinical trials, and personalized medicine.However, low success rate long tumorigenesis period largely limited their usage.In present studies, we compared PDX establishment between hepatocellular (HCC) metastatic liver (MLC), identified key factors affecting transplantation...
This report aims to investigate the feasibility and outcomes of neoadjuvant imatinib mesylate (IM) administration followed by organ-preserving surgery (OPS) for patients with locally advanced duodenal gastrointestinal stromal tumor (GIST). Between 2012 2015, 10 consecutive GISTs were treated in Peking University Cancer Hospital. Multidisciplinary assessment was implemented, pancreaticoduodenectomy (PD) initially indicated as most probable surgical procedure all patients. To attempt create...
The present study examined the associations between recent life stress and responses to acute psychological stress, how these varied with executive control. Heart rate (HR), heart variability (HRV), salivary cortisol, affective states were measured before, during after Trier Social Stress Test (TSST), an effective laboratory stressor, in 54 healthy participants, control function was tested a Go/No-Go task neutral context on different day. hierarchical multiple regression analysis showed that...
Pancreatic cancer is lethal due to lack of perceptible symptoms and effective treatment methods. Immunotherapy may provide promising therapeutic choices for malignant tumors like pancreatic cancer. Tumor‐infiltrating lymphocytes ( TIL ) in tumor mesenchyme could recognize peptide antigens presented on the surface cells. The present study aimed test relationship between T cell receptor TCR β repertoire peripheral blood, also investigate intra‐tumor spatial heterogeneity To best our knowledge,...