A5013025792- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Antibiotic Resistance in Bacteria
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Bacterial biofilms and quorum sensing
- Atrial Fibrillation Management and Outcomes
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare professionals’ stress and burnout
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Empathy and Medical Education
- Genetic Syndromes and Imprinting
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
Second People’s Hospital of Yibin
2024
Zhejiang University of Technology
2024
State Key Laboratory of Industrial Control Technology
2024
Henan Polytechnic University
2024
University of Electronic Science and Technology of China
2024
First Affiliated Hospital of Guangzhou Medical University
2021-2023
State Key Laboratory of Respiratory Disease
2021-2023
Guangzhou Medical University
2015-2023
A number of studies have examined the association between tumor protein 53 (TP53) mutations and clinical outcome in patients with non-small-cell lung cancer (NSCLC), although these yielded conflicting results. In present study, electronic databases updated to September 2015 were searched find relevant studies. meta-analysis was performed on eligible studies, which quantitatively evaluated TP53 survival NSCLC. Subgroup sensitivity analyses performed. total 19 that involved a 6,084 NSCLC...
How the genomic landscape of a tumor shapes formation tertiary lymphoid structure (TLS) and how might TLS alter clinical outcome or response to immunotherapy had not been systematically explored. Utilizing transcriptome data solid tumors on TCGA, we quantified based previous identified 12-chemokine signature evaluated its correlation with mutation/neoantigen burden, functional mutation oncogenes presence viral infection. Clinical was integrated decide prognostic significance for different...
Abstract Background Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The impact of PTEN microenvironment, especially regarding T cell infiltration across types is not well understood. Methods Utilizing Cancer Genome Atlas (TCGA) publicly available dataset immunotherapy, we explored correlation expressing level or...
Krüppel-like factor 4 (KLF4) is a zinc-finger protein that plays important roles in stem cells and the development of gastric cancers. However, role KLF4 primary lung cancer unknown. The purpose this study to determine possible cancer.The expression tissues case-matched normal were determined by mRNA analyses. effects on cell proliferation, clonogenic formation, cycle progression cultured or bronchial epithelial after enforced overexpression small interfering RNA knockdown. vivo antitumor...
The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in migration, motility invasion. object this study investigate the involvement CTHRC1 NSCLC invasion metastasis.A proteomic analysis was performed identify different expression proteins between normal tissues. Cell lines stably express CTHRC1, MMP7, MMP9 were established. Invasion migration determined by scratch transwell...
// Liyan Jiang 1, * , Xinying Su 2, Tianwei Zhang 2 Xiaolu Yin Meizhuo 3 Haihua Fu Hulin Han Yun Sun Lili Dong 1 Jialin Qian Yanhua Xu 4 Xuan Paul R. Gavine Yanbin Zhou 5 Kun Tian 6 Jiaqi Huang 7 Shen Haiyi Yihong Yao Baohui Yi Gu Shanghai Chest Hospital, Jiao Tong University, Shanghai, China Asia & Emerging Markets, iMed, AstraZeneca, R&D Information, Global Medicines Development, The First Affiliated Yat-Sen Guangdong, General Hospital of Chengdu Military Region PLA, Sichuan, R&D,...
Abstract Background Photodynamic therapy (PDT) is a clinically implemented modality to combat malignant tumor, while its efficacy largely limited by several resistance factors from tumor microenvironment (TME), such as hypoxia, anti-oxidant systems, and ATP-dependent adaptive resistances. The aim of this work construct multifunctional nanoplatform remodel multiple resistant TME for enhanced PDT. Results Here, targeting nano-reactor was facilely constructed reverse the resistances PDT...
AbstractKrüppel-Like Factor 4 (KLF4) functions as a tumor suppressor in some cancers, but its molecular mechanism is not clear. Our recent study also showed that the expression of KLF4 dramatically reduced primary lung cancer tissues. To investigate possible role cancer, we stably transfected into cells from cell lines H322 and A549 to determine cells' invasion ability. results ectopic extensively suppressed Matrigel. This effect was independent KLF4-mediated p21 up-regulation because had...
It is well accepted that recurrent laryngeal nerve paralysis a severe complication of esophagectomy or lymphadenectomy performed adjacent to the nerves. Herein, determination effectiveness implementing continuous monitoring reduce incidence after was sought. A total 115 patients diagnosed with esophageal cancer were enrolled in thoracic section Tangdu Hospital Fourth Military Medical University from April 2008 2009. Clinical parameters patients, morbidity, and mortality following resection...
In this work, MUC1 aptamer (designated S2.2) modified and vinorelbine (VRL) loaded lipid-polymer hybrid nanoparticles (Apt-VRL-NPs) were prepared.
Abstract Background Increasing evidence indicates that four and a half LIM domains 2 (FHL2) plays crucial role in the progression of various cancers. However, biological functions molecular mechanism FHL2 lung adenocarcinoma (LUAD) remain unclear. Methods We evaluated prognostic value LUAD using public datasets further confirmed its with our clinical data. The were by vitro vivo experiments. Pathway analysis rescue experiments subsequently performed to explore which promoted LUAD. Results...
Because cell signaling and metabolic pathways are executed through proteins, protein signatures in primary tumors useful for identifying key nodes networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine lung cancer tissues.We analyzed 126 proteins phosphorylation sites case-matched normal tumor samples from 101 patients reverse-phase array (RPPA) assay. The results showed that 18 molecules were significantly different (p<0.05) by at...
Abstract Background This study was designed to determine whether advanced non-small-cell lung cancer (NSCLC) patients with high copy number of epidermal growth factor receptor (EGFR) can benefit from treatment EGFR-tyrosine kinase inhibitors (TKIs). Methods EGFR gene assessed by fluorescence in situ hybridization (FISH) and mutations tested using Luminex xTAG technology 502 TKI-treated NSCLC patients. The association between both biomarkers clinical EGFR-TKI were analyzed. Results FISH +...
Isolation of colorectal cancer (CRC) cell populations enriched for stem cells (CSCs) may facilitate target identification. There is no consensus regarding the best methods isolating CRC (CRC-SCs). We determined suitability various cellular models and markers isolation CRC-SCs. Established human lines, established lines passaged through mice, patient-derived xenograft (PDX)-derived cells, early passage/newly directly from clinical specimens were studied. Cells FAC-sorted CRC-SC CD44, CD133,...
Background Detection of Acinetobacter baumannii has been relying primarily on bacterial culture that often fails to return useful results in time. Although DNA-based assays are more sensitive than detecting the pathogen, molecular inconsistent and challenged by doubts false positives, such as those due system- environment-derived contaminations. In addition, these tools require expensive laboratory instruments. Therefore, establishing for field use simpler platforms. The loop-mediated...
Purpose: To determine whether distinct tissue immune microenvironments differentially impact on clinical outcome in non-small cell lung cancer (NSCLC), an extended analysis of PD-1/PD-L1 and Tumor Infiltrating Lymphocytes (TILs) was performed. Materials Methods: 1016 NSCLC mRNA-sequence samples from The Genome Data Analysis Center (TCGA) 275 mRNA-microarray Gene Expression Omnibus (GEO) were included as testing cohort validation respectively. Enrichment scores CD8+ T cells' metagene used for...
Cooperative photothermal therapy (PTT) and photodynamic (PDT) represents a promising strategy to conquer tumor with synergistic effect, while their long-term efficacy has been strictly limited by the multiple resistances of tumor. Here, we reported core–shell nanoplatform for enhanced PTT/PDT combination against metastatic breast cancer. The nanosystem had photosensitizer chlorin e6 (Ce6) rapamycin (RAP) pure drugs core polydopamine (PDA) shell, surface PEGylation. Notably, found that RAP...