A5055143613- Pancreatic and Hepatic Oncology Research
- Peripheral Artery Disease Management
- Thyroid Cancer Diagnosis and Treatment
- Vascular Procedures and Complications
- Thyroid and Parathyroid Surgery
- Cerebrovascular and Carotid Artery Diseases
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- Aortic aneurysm repair treatments
- Wireless Sensor Networks and IoT
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Aortic Disease and Treatment Approaches
- Traditional Chinese Medicine Studies
- Coronary Interventions and Diagnostics
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Cancer-related Molecular Pathways
- Colorectal Cancer Screening and Detection
- Extracellular vesicles in disease
- Aortic Thrombus and Embolism
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Abstract Background Photodynamic therapy (PDT) is a clinically implemented modality to combat malignant tumor, while its efficacy largely limited by several resistance factors from tumor microenvironment (TME), such as hypoxia, anti-oxidant systems, and ATP-dependent adaptive resistances. The aim of this work construct multifunctional nanoplatform remodel multiple resistant TME for enhanced PDT. Results Here, targeting nano-reactor was facilely constructed reverse the resistances PDT...
Inguinal lymph node metastasis in urothelial carcinoma is exceptionally rare. Here, We report a case of bladder cancer with inguinal and, through searching our hospital's database, identified two additional similar patients managed at center since 1990. All underwent PET/CT scans, and cases, biopsies confirmed metastatic carcinoma. One elderly female presented as the initial sign recurrence. This underscores increased risk distant highlights critical need for vigilant monitoring recurrent...
Plasma cell-free DNA (cfDNA) has been used to monitor gene mutations and diagnose tumors. Discriminating parathyroid carcinoma (PC) from adenoma (PA) before surgery is difficult because of the overlap in clinical features between neoplasms. We aimed detect cfDNA plasma samples PC PA patients predict CDC73 status tumor tissue help differential diagnosis Eighteen 13 were enrolled. was detected using next-generation sequencing, with matched peripheral white blood cells as a control. via...
To describe the genetic landscape and clinical characteristics of Chinese patients diagnosed with papillary thyroid cancer (PTC) to determine which high-risk suggest a likelihood lymph node metastasis (LNM) lateral (LLNM).Data from previously untreated PTC collected between May 2018 December 2020 14 hospitals in China were analyzed retrospectively. High-risk pathologic defined as T3/T4, N(+), N1b(+) stages. All tested for 57 genes by second-generation sequencing. The t-test, chi-square test,...
Tumour microenvironment has been recognized as a crucial factor influencing disease progression. However, relevant features and functions are insufficiently understood in parathyroid neoplasia. Single-cell RNA sequencing was performed to profile the transcriptome of 27,251 cells from 4 adenoma (PA) tissue samples. External transcriptomic datasets immunofluorescence staining microarray were set for expression validation. Eight major cell types various subpopulations finely identified PA. We...
Pancreatic cancer is an aggressive and challenging malignancy with limited treatment options, largely attributed to the dense tumor stroma intrinsic drug resistance. Here, we introduce a novel iron-containing nanoparticle formulation termed PTFE, loaded ferroptosis inducer Erastin, overcome these obstacles enhance pancreatic therapy. The PTFE nanoparticles were prepared through one-step assembly process, consisting of Erastin-loaded PLGA core stabilized by MOF shell formed coordination between Fe
Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory human malignancies. F-box only proteins (FBXO) are core components SKP1-cullin 1-F-box E3 ubiquitin ligase, which have been reported to play crucial roles in tumor initiation and progression via ubiquitination-mediated proteasomal degradation. However, clinical implications biological functions FBXOs PDAC not fully clarified. Herein we perform a comprehensive analysis for values functional using different public databases....
Abstract Objective To enhance the accuracy in predicting lymph node metastasis (LNM) preoperatively patients with papillary thyroid microcarcinoma (PTMC), refining “low‐risk” classification for tailored treatment strategies. Methods This study involves development and validation of a predictive model using cohort 1004 PTMC undergoing thyroidectomy along central neck dissection. The data was divided into training ( n = 702) 302). Multivariate logistic regression identified independent LNM...
Hyperparathyroidism is the third most common endocrine disease. Parathyroid adenoma (PA) accounts for approximately 85% of cases primary hyperparathyroidism, but molecular mechanism not fully understood. Herein, we aimed to investigate genetic and transcriptomic profiles sporadic PA.Whole-exome sequencing (WES) transcriptome (RNA-seq) 41 patients with PA RNA-seq 5 normal parathyroid tissues were performed. Gene mutations characterized expression changes identified. To elucidate underlying...
Background: Laparoscopic surgery has been in great demand over the past decades; it also brought several obstacles, such as increasing difficulty maintaining hemostasis, changes surgical approach, and reduced field of vision. Locating bleeding point can help surgeons to control quickly, however, date, there have no tools designed for automatic tracking laparoscopic operations. Herein, we proposed a spatiotemporal hybrid model based on faster region-based convolutional neural network (RCNN)...
Parathyroid carcinoma (PC) is a rare endocrine malignancy with poor outcomes. Over 60% of PC patients experience repeated disease recurrence or metastasis. The significance cervical lymph node dissection (LND) for remains inconclusive.PC diagnosed at Peking Union Medical College Hospital between 1992 and 2021 were reviewed retrospectively. Clinical data, initial tumor histological staging, parafibromin histochemical staining results, Ki67 index, CDC73 gene mutation status outcome information...
Abstract Background The safety of total laparoscopic pancreaticoduodenectomy still remains controversial. Laparoscopic assisted (LAPD) may be an alternative selection. purpose the present study is to compare a consecutive cohort LAPD and open (OPD) from single surgeon. Methods A comparison was conducted between OPD January 2013 December 2018. Perioperative outcomes short-term oncological results were compared. Univariate multivariable analyses performed determine associations among...
Abstract Pancreatic cancer is one of the most lethal tumors across world with an overall 5-year survival rate 9%, and great efforts have been devoted in early diagnosis treatment past decades. Competing endogenous RNAs are novel specific regulatory mechanisms gene expression, researches indicated its important roles tumor regulation. In this study, we explored circ-0050102 expression pancreatic impacts on malignant phenotypes further investigated correlations among circ-0050102, miR-1182...
SignificanceNear-infrared autofluorescence (NIRAF) utilizes the natural of parathyroid glands (PGs) to improve their identification during thyroid surgeries, reducing risk inadvertent removal and subsequent complications such as hypoparathyroidism. This study evaluates NIRAF's effectiveness in real-world surgical settings, highlighting its potential enhance outcomes patient safety.AimWe evaluate NIRAF detecting PGs thyroidectomy central neck dissection investigate characteristics both fresh...
Percutaneous kyphoplasty (PKP) is now widely performed to treat VCF, which usually caused by osteoporosis. Previous researches have reported unsuspected malignancies found biopsy. However, the safety and cost-effective profiles of routine biopsy during PKP are unclear. The purpose this study was evaluate feasibility in treatment VCF.Ninety-three patients (September 2007-November 2010) undergoing without were reviewed as control group. One hundred three consecutive (November 2010-September...
Objective: To investigate the clinicopathologic features and prognosis of patients who had clear cell renal carcinoma (CCRCC) with metastasis to pancreas. Methods: From Jan, 2000 Dec, 2018, 18 pathologically diagnosed pancreas were enrolled at Peking Union Medical College Hospital. The clinical pathological data retrospectively analyzed. Results: 11 out male, other 7 female. average age onset CCRCC was 51.4 years. 8 cases (44.4%) occurred in left kidney, 10 (55.6%) right kidney tumor. Three...
Percutaneous transluminal angioplasty and stenting (PTA + stent) has gained acceptance as a primary treatment modality for the superficial femoral artery (SFA) diseases. Popliteal embolization (PAE) is severe complication in SFA interventions. The purpose of this study was to evaluate incidence, risk factors, prognosis PAE PTA stent.Chronic arteriosclerosis cases that underwent stent were reviewed from retrospectively maintained database. Runoff vessels evaluated all before after...
<title>Abstract</title> Laparoscopic pancreatic surgery remains highly challenging due to the complexity of pancreas and surrounding vascular structures, with risk injuring critical blood vessels such as Superior Mesenteric Vein (SMV)-Portal (PV) axis splenic vein. Here, we evaluated High Resolution Network (HRNet)-Full Convolutional (FCN) model for its ability accurately identify contours improve surgical safety. Using 12,694 images from 126 laparoscopic distal pancreatectomy (LDP) videos...
Thyroid surgery has undergone significant transformation with the introduction of minimally invasive techniques, particularly robotic and endoscopic thyroidectomy. These advancements offer improved precision faster recovery but also present unique challenges. This study aims to compare learning curves, operational efficiencies, patient outcomes versus