A5085051340- Cancer Genomics and Diagnostics
- Parathyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Genetic Syndromes and Imprinting
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Connective tissue disorders research
- Cancer, Stress, Anesthesia, and Immune Response
- Thyroid and Parathyroid Surgery
- Tracheal and airway disorders
- Sarcoma Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Genomics and Rare Diseases
First Affiliated Hospital of Xiamen University
2025
Beijing Children’s Hospital
2025
Capital Medical University
2025
Shenzhen Children's Hospital
2024
Peking Union Medical College Hospital
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Jiangyin People's Hospital
2023
Nantong University
2023
Peking University
2013-2022
Center for Life Sciences
2017-2022
Sorghum is a food and feed cereal crop adapted to heat drought staple for 500 million of the world's poorest people. Its small diploid genome phenotypic diversity make it an ideal C4 grass model as complement C3 rice. Here we present high coverage (16–45 × ) resequenced genomes 44 sorghum lines representing primary gene pool spanning dimensions geographic origin, end-use taxonomic group. We also report first S. propinquum, identifying 8 M high-quality SNPs, 1.9 indels specific loss gain...
Significance In a few milliliters of blood from cancer patient, one can isolate circulating tumor cells (CTCs). Originating the primary tumor, CTCs seed metastases, which account for majority cancer-related deaths. We demonstrate analyses whole genome single CTCs, are highly needed personalized treatment. discovered that copy number variations (CNVs), major genomic variations, specific to types, reproducible cell cell, and even patient patient. hypothesize CNVs at certain loci selected lead...
Esophageal squamous dysplasia is believed to be the precursor lesion of esophageal cell carcinoma (ESCC); however, genetic evolution from ESCC remains poorly understood. Here, we applied multi-region whole-exome sequencing samples two cohorts, 45 patients with matched and samples, 13 tumor-free only samples. Our analysis reveals that heavily mutated harbors most driver events reported in ESCC. Moreover, polyclonal, remarkable heterogeneity often observed between tumors their neighboring...
Copy number alteration (CNA) is a major contributor to genome instability, hallmark of cancer. Here, we studied genomic alterations in single primary tumor cells and circulating (CTCs) from the same patient. Single-nucleotide variants (SNVs) both samples occurred sporadically, whereas CNAs among emerged accumulatively rather than abruptly, converging toward CNA CTCs. Focal affecting MYC gene PTEN were observed only minor portion but present all CTCs, suggesting strong selection metastasis....
Abstract Purpose: Genomic analyses of small-cell lung cancer (SCLC) are limited by the availability tumor specimens. This study aimed to investigate suitability single-cell sequencing circulating cells (CTC) as a method inferring evolution and progression SCLCs. Experimental Design: Between July 1, 2011, 28, 2014, 48 consecutively diagnosed patients with SCLC were recruited for this study. CTCs captured from each patient CellSearch system. Somatic mutations copy number alterations (CNA)...
Hepatocellular carcinoma (HCC) is a common malignant tumor with high rate of metastasis and recurrence. Although immune checkpoint blockade (ICB) has emerged as promising type immunotherapy in advanced HCC, treatment ICB alone achieves an objective remission less than 20%. Thus, combination therapy strategies needed to improve the response therapeutic effect. A light-triggered disassembly nanoplatform (TB/PTX@RTK) co-loaded aggregation induced emission (AIE) photosensitizer (TB) paclitaxel...
Abstract In pancreatic cancer, adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous in the same tumour represents ∼4% of total incidence. To date, genomic features this mixed are still unknown. We analysed genomes 17 PASCs 34 adenocarcinomas (PDACs), showed that PASC carried highly enriched TP53 mutations 3p loss as compared with PDAC. also adenomatous components harboured comparable alterations, suggesting two cellular develop from progenitor cancer cells. Our...
Blood microbiome signatures in patients with type 1 diabetes (T1D) remain unclear. We profile blood using 16S rRNA gene sequencing 77 controls and 64 children new-onset T1D, compared it the gut oral microbiomes. The of T1D is characterized by increased diversity perturbed microbial features, a significant increase potentially pathogenic bacteria controls. Thirty-six representative genera were identified random forest analysis, providing strong discriminatory power for an AUC 0.82. PICRUSt...
This study aims to analyze the clinical characteristics of children with tracheobronchial foreign body and investigate factors influencing surgical duration rigid bronchoscopic removal under general anesthesia. We retrospectively identified 421 diagnosed undergoing bronchoscopy between January 2020 December 2021. A comprehensive analysis was conducted on patient demographics, including age, weight, gender, American Society Anesthesiologists (ASA) physical status classification, type...
To investigate the technique for dorsal median sulcus (DMS) mapping and assess its application value in preserving columnn (DC) function during intramedullary space occupying surgery based on a single-center experience. A retrospective analysis was conducted 41 cases of spinal cord tumor admitted to Department Neurosurgery at First Affiliated Hospital Xiamen University from March 2017 August 2023. All included underwent intraoperative electrophysiological monitoring, were divided into study...
Background As playing important roles in gene regulation, microRNAs (miRNAs) are believed as indispensable involvers the pathogenesis of myocardial infarction (MI) that causes significant morbidity and mortality. Working on a hypothesis modulation only some key members miRNA superfamily could benefit ischemic heart, we proposed microarray based network biology approach to identify them with recognized clinical effect propranolol prompt. Methods A long-term MI model rat was established this...
Colorectal cancer is a heterogeneous group of malignancies with complex molecular subtypes. While colon has been widely investigated, studies on rectal are very limited. Here, we performed multi-region whole-exome sequencing and single-cell whole-genome to examine the genomic intratumor heterogeneity (ITH) tumors.We sequenced nine tumor regions 88 single cells from two patients tumors same classification characterized their mutation profiles somatic copy number alterations (SCNAs) at...
Background . Primary hyperparathyroidism (pHPT) in pregnancy is a rare event, but it poses significant risk to mothers and fetuses. The optimal treatment strategy remains controversial. Methods We present consecutive series of twelve pregnant women with pHPT. Results Twelve were diagnosed pHPT during or the postpartum period. Four them presented no symptoms mild symptoms. patients experienced serious complications, including hypercalcaemic crisis, acute pancreatitis, eclampsia. Another four...
Parathyroid carcinoma (PCa) is a rare endocrine neoplasia that typically has unfavourable outcomes. The contribution of long non-coding RNAs (lncRNAs) to the development malignant and benign parathyroid tumours remains largely unknown. In this study, we explored transcriptomic profiling lncRNA mRNA expression in 6 PCa, adenoma (PAd) 4 normal (PaN) tissues. total, 2641 transcripts 2165 were differentially expressed between PCa PAd. Enrichment analysis demonstrated dysregulated involved mainly...
It is showed that inflammation causative factor for PCOS, leading to a decline in ovarian fertility. Previous studies have reported tea consumption can reduce the incidence of cancer. We speculate catechins from oolong (Camellia sinensis (L.) O. Kuntze) may potential therapeutic effect on PCOS. This study aims investigate effects uterus polycystic ovary syndrome (PCOS) mice induced by insulin combined with human chorionic gonadotropin (hCG).Sixty female were divided into 6 groups (n = 10):...
Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although social cultural impacts and Mongolian population been well documented, explorations their genome structure genetic imprints on other populations lacking. We here present male individual. The was de novo assembled using total 130.8-fold genomic data produced from massively parallel whole-genome sequencing. identified high-confidence variation sets, including...
Parathyroid carcinoma (PC) is a rare endocrine malignancy. Surgical resection curative for local lesions, while effective therapies are lacking recurrent or metastatic PCs. To study whether targeted could be applied in PCs, potential therapeutic targets were identified with next-generation sequencing (NGS). DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) sections 19 PC samples. A panel of 560 genes sequenced NGS to identify genomic alterations at an average depth 581×. In...
Abstract Accumulating evidence showed that cytokines are involved in the development of cancer. IL‐13 was to induce epithelial–mesenchymal transition and promote metastasis colorectal cancer, providing a promising therapeutic target for cancer patients. Interestingly, recent studies propofol, one most common intravenous anesthetic agent, may have antitumor function different type. However, impact propofol on induced remains unknown. Herein, we found can effectively suppress cell...
Objective . Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism, but its preoperative diagnosis and management remain inconclusive. Method We retrospectively identified patients with cystic adenomas who underwent surgery at Peking Union Medical College Hospital. Results Patients had higher serum intact hormone calcium levels, larger maximum tumor diameter, lower inorganic phosphorus level than did those solid adenomas. were predominantly male, hypercalcemic crisis...
The systemic immune-inflammation index (SII) is an independent prognostic predictor of hepatocellular carcinoma (HCC). present investigation examined whether association exists between preoperative SII value and postoperative acute kidney injury (pAKI) in HCC patients.The study included 479 hepatitis B virus (HBV)-associated patients undergoing hepatectomy. was calculated as P × N/L, where P, N, L represent the counts platelets, neutrophils, lymphocytes routine blood test, respectively....