A5071522984- Endometrial and Cervical Cancer Treatments
- Myasthenia Gravis and Thymoma
- Ovarian cancer diagnosis and treatment
- Pituitary Gland Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Histiocytic Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Oral and Maxillofacial Pathology
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Thyroid and Parathyroid Surgery
- Molecular Biology Techniques and Applications
- Viral-associated cancers and disorders
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
Max Planck Institute for Molecular Genetics
2025
North China Electric Power University
2025
European Bioinformatics Institute
2021-2023
Beijing Tsinghua Chang Gung Hospital
2022-2023
Tsinghua University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2022
Peking Union Medical College Hospital
2007-2022
Academia Sinica
2019
Academy of Medical Sciences
2019
Pathological Society
2017
The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a gene or protein interest expressed. brings together data from >4500 expression studies >65 different species, across tissues. It makes these freely available in easy visualise form, after expert curation accurately represent intended experimental design,...
BackgroundTyrosine kinase inhibitors (TKIs) are clinically effective in non-small cell lung cancer (NSCLC) patients harbouring epidermal growth factor receptor (EGFR) oncogene mutations. Genetic factors, other than EGFR sensitive mutations, that allow prognosis of TKI treatment remain undefined.MethodsWe retrospectively screened 423 consecutive with advanced NSCLC and 19del or 21L858R A total 71 whose progression-free survivals (PFS) were shorter 6 months longer 24 included stratified into...
// Chao Liu 1, 2, * , En-Dong Yun-Xiao Meng 3, Xiao-Ming Dong 4 Ya-Lan Bi 3 Huan-Wen Wu Yan-Chao Jin 2 Ke Zhao Jian-Jie Li 5 Miao Yu Yi-Qun Zhan Hui Chen Chang-Hui Ge Yang and Chang-Yan 1 An Medical University, Hefei, 230032, China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Institute Radiation Medicine, Beijing, 100850, Department Pathology, Peking Union College Hospital, Chinese Academy Sciences College, Tsinghua 100730, Tianjin School Chemical Engineering...
Expression Atlas (www.ebi.ac.uk/gxa) and its newest counterpart the Single Cell (www.ebi.ac.uk/gxa/sc) are EMBL-EBI's knowledgebases for gene protein expression localisation in bulk at single cell level. These resources aim to allow users investigate their normal tissue (baseline) or response perturbations such as disease changes genotype (differential) across multiple species. Users invited search genes metadata terms species biological conditions a standardised consistent interface....
Parathyroid carcinoma (PC) is a rare endocrine malignancy with poor outcomes. Although some mutations such as CDC73 have been found in patients, the molecular mechanism of PC still needs extensive data to clarify. Whole-genome sequencing (WGS) was performed frozen samples from 23 patients. Peripheral leukocytes were collected 14 patients and served controls. Somatic germline gene alterations, copy number abnormalities structural variants detected. Inactivating identified 39.1% but only one...
Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-19) patients in progression stage, a detailed understanding pertinent cells recovered is lacking. We performed single-cell RNA sequencing samples from COVID-19 and healthy controls. created comprehensive landscape with more than 260,000 peripheral blood mononuclear (PBMCs) 41 by integrating our dataset previously reported datasets, which included collected between 27 47 days after symptom onset. According...
Abstract: Ovarian low-grade serous carcinoma (LGSC) and high-grade have distinct molecular profiles, clinical behaviors, treatment responses. The survival advantage for patients with compared histology remains controversial. We retrospectively reviewed the medical charts of 381 ovarian at Peking Union Medical College Hospital from 2007 to 2010. Patients were classified into two groups according MD Anderson two-tier system: 35 (9.2%) cases LGSC 346 carcinoma. cancer had a significantly...
To investigate the expression profiles of cancer stem cells (CSCs) markers CD133 and CD44 in a cohort medullary thyroid carcinoma (MTC) patients, their prognostic values during 10-year follow-up.MTC samples were obtained for H&E immunohistochemical analysis. Survival analysis was performed using Kaplan-Meier method log-rank test.Both positives higher MTC than control. High positively correlated with capsule invasion each other, co-expression significantly invasion, tissue metastases at...
Abstract Background The prevalence of Lynch syndrome and screening strategies for this disorder in Chinese patients with endometrial cancer have seldom been investigated. Such data would be essential the screening, prevention, genetic counseling, treatment syndrome. purpose prospective study was to determine accuracy mismatch repair (MMR) protein immunohistochemistry (IHC), microsatellite instability (MSI) test, clinical diagnostic criteria syndrome‐associated (LS‐EC) a cohort. Methods All...
Object: To assess the effects of lymphovascular space invasion (LVSI) on cancer recurrence and survival in patients with primary epithelial ovarian cancer.Methods: A retrospective study was conducted stage I-IV who underwent cytoreductive surgery.LVSI is defined as presence tumor cells within an endothelium-lined space, patients' pathologic slides were reevaluated by gynecological pathologists.Survival analysis performed to compare risk factors.Results: total 492 included analysis.The...
Parathyroid carcinoma (PC) is a rare endocrine malignancy. Surgical resection curative for local lesions, while effective therapies are lacking recurrent or metastatic PCs. To study whether targeted could be applied in PCs, potential therapeutic targets were identified with next-generation sequencing (NGS). DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) sections 19 PC samples. A panel of 560 genes sequenced NGS to identify genomic alterations at an average depth 581×. In...
To explore the survival and definition of stage IA mixed endometrial carcinoma.From June 1, 2010, to 2017, cases with cancer were included in this study. The outcomes compared among patients endometrioid (group A), nonendometrioid B), subtypes C) different proportions components (<5%, >50%, others).In total, 890 included, comprising 808 (90.8%), 33 (3.7%), 47 (5.3%) groups A, B, C, respectively. After a median follow-up 55.9 months, B C had significantly more inferior disease-free survival,...
Abstract Little is known about the epidemiological and clinicopathological characteristics of endometrial endometrioid carcinoma (EEC) coexisting with or arising in adenomyosis (EEC-A EEC-AIA) due to their rarity. This study compared EEC-A EEC-AIA without adenomyosis. Cases cancer treated at center from June 1, 2010, 2017, were reviewed. The epidemiological, survival outcomes among three groups subtypes: group A, stage IA patients adenomyosis; B, EEC-A; C, EEC-AIA. Among 2080 reviewed, C...
Intrathoracic involvement is common in Castleman disease (CD), but CD-associated diffuse parenchymal lung (DPLD) rare and not well-reported. We conducted a retrospective analysis of 262 CD patients with definite pathological diagnosis who were hospitalized between 1999 2015. Twenty-two had DPLD based on chest computed tomography (CT) scans. Among them, 9 male 13 female, mean age 45.3 years. Coughing (72.7%), fever (68.2%), dyspnea (59.1%) the clinical manifestations. In high-resolution CT,...
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell form of histiocytosis that can affect the central nervous system. ECD predominantly affects adults, and only few pediatric cases have been reported. The co-occurrence Langerhans (LCH) exceedingly rare. An 11-year-old boy, who was diagnosed with LCH 7 years previously, presented multiple giant intracranial lesions. At time his initial diagnosis, one lesion observed, it began to enlarge. Currently, up lesions be observed in this...