A5012049637- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Metabolomics and Mass Spectrometry Studies
- Immune cells in cancer
- Gut microbiota and health
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Quantum optics and atomic interactions
- Mesenchymal stem cell research
- Protein Degradation and Inhibitors
- Vestibular and auditory disorders
- Diabetes and associated disorders
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Cellular transport and secretion
- Single-cell and spatial transcriptomics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Histiocytic Disorders and Treatments
Yuhuangding Hospital
2025
University of Science and Technology of China
2016-2024
Affiliated Hospital of Qingdao University
2024
Qingdao University
2024
St. Jude Children's Research Hospital
2021-2024
Children's Research Hospital
2023
University of Arkansas at Fayetteville
2023
Capital Medical University
2017-2022
Beijing Tian Tan Hospital
2017-2022
Chinese Institute for Brain Research
2017-2020
The microbiota control regional immunity using mechanisms such as inducing IL-17A-producing γδ T (γδT-17) cells in various tissues. However, little is known regarding hepatic γδT that are constantly stimulated by gut commensal microbes. Here we show liver-resident and predominant producers of IL-17A. sustain γδT-17 cell homeostasis, including activation, survival proliferation. global quantity affects the number cells; indeed, E. coli alone can generate a dose-dependent manner....
Type 1 innate lymphoid cells (ILC1s) represent the predominant population of liver ILCs and function as important effectors regulators immune responses, but cellular heterogeneity ILC1s is not fully understood. Here, single-cell RNA sequencing flow cytometric analysis demonstrated that could be dissected into Ly49E+ Ly49E− populations with unique transcriptional phenotypic features. Genetic fate-mapping revealed strong cytotoxicity originated from embryonic non–bone marrow hematopoietic...
Hepatitis B virus (HBV) is a major risk factor for development of hepatocellular carcinoma (HCC), at least partially due to dysfunctional anti-HBV adaptive immunity; however, the role innate immune response HBV in this process not well understood. In study, low-dose polyinosinic:polycytidylic acid (poly [I:C]), natural killer (NK) cell activator (3 μg/g body weight, twice/week 8 weeks), induced HCC transgenic (HBs-Tg) mice, with an incidence 100% after 6 months, while HBs-Tg mice without...
Background and Aims: Chronic HBV infection is the leading cause of HCC a serious health problem in China, East Asia, North African countries. Effective treatment HBV‐related currently unavailable. This study evaluated therapeutic potential T‐cell immunoreceptor with Ig ITIM domains (TIGIT) blockade HCC. Approach Results: A mouse model spontaneous was generated by replacing wild‐type hepatocytes HBsAg + (namely HBs‐HepR mice). The tumors mice were inflammation‐associated HCC, similar to...
Nuclear factor Foxp3 determines regulatory T (Treg) cell fate and function via mechanisms that remain unclear. Here, we investigate the nature of Foxp3-mediated gene regulation in suppressing autoimmunity antitumor immune response. Contrasting with previous models, find Foxp3–chromatin binding is regulated by Treg activation states, tumor microenvironment, antigen cytokine stimulations. Proteomics studies uncover dynamic proteins within proximity upon TCR or IL-2 receptor signaling vitro,...
Significance IL-17A promotes tumorigenesis, metastasis, and viral infection. However, the underlying mechanisms remain elusive. By using diverse gene-deficient mice, antibody depletion, animal models, we show that infection by constraining NK cell antitumor antiviral activity via inhibition of maturation. The ablation signaling increases terminally mature CD27 − CD11b + cells, whereas constitutive reduces cells. suppresses IL-15–induced phosphorylation STAT5 up-regulation SOCS3 in leading to...
Gut-derived bacterial products contribute to liver inflammation and injury during chronic hepatitis B virus infection; however, the underlying mechanisms remain obscure. In this study, surface antigen transgenic (HBs-Tg) mice their wild-type (WT) control C57BL/6 were injected with CpG-oligodeoxynucleotides (ODNs) mimic translocation of gut microbial into systemic circulation. We found that, compared WT mice, HBs-Tg oversensitive CpG-ODN-induced injury, which was dependent on natural killer T...
The aging lungs are vulnerable to chronic pulmonary diseases; however, the underlying mechanisms not well understood. In this study, we compared of 20-24-month-old mice with young 10-16-week-old mice, and found that airway epithelial cells significantly upregulated expression uteroglobin-related protein 1 (UGRP1), which was responsible for higher levels CCL6 in lungs. Alveolar macrophages (AMs) changed intrinsically aging, exhibiting a decrease cell number altered gene expression. Using...
Abstract The alignment-dependent photoelectron spectrum is a valuable tool for mapping out the electronic structure of molecular orbitals. However, this approach may not be applicable to all molecules, such as CO 2 , ionization process in linearly polarized laser field involves contributions from orbitals other than highest occupied orbital (HOMO). Here, we conducted theoretical investigation into N and near-circularly using Coulomb-corrected strong-field approximation (CCSFA) method...
This study aimed to explore the impact of hydroxysafflor yellow A (HSYA) on proliferation, cell cycle, and apoptosis Jurkat cells, serving as a representative model T-cell acute lymphoblastic leukemia (T-ALL), underlying molecular mechanism its action. HSYA was administered cells. Cell proliferation assessed using Counting Kit-8 (CCK-8) assay, flow cytometry utilized analyze cycle distribution apoptosis. The expression levels Notch1, c-Myc, Hes1 at both mRNA protein were employing reverse...
Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is mediated by an inappropriate attack HBV-specific T cells in patients. However, this immunopathogenic process has not been clarified because of the lack a suitable animal model. Here, we used immunocompetent Fah-/- mice as recipients adoptive transfer HBsAg+ hepatocytes from HBs-Tg to replace recipient (HBs-HepR). HBs-HepR exhibited persistent HBsAg expression with chronic hepatitis and eventually developed HCC prevalence...
The outcomes of HBV infections are related to complex immune imbalances; however, the precise mechanisms by which induces dysfunction not well understood.
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell form of histiocytosis that can affect the central nervous system. ECD predominantly affects adults, and only few pediatric cases have been reported. The co-occurrence Langerhans (LCH) exceedingly rare. An 11-year-old boy, who was diagnosed with LCH 7 years previously, presented multiple giant intracranial lesions. At time his initial diagnosis, one lesion observed, it began to enlarge. Currently, up lesions be observed in this...
Liver‐resident natural killer (LrNK) cells are a unique subset of NK that distinct from conventional cells. However, little is known about the mechanisms by which LrNK mature. In this study, we discovered exhibit relatively immature phenotype and impaired cytotoxic capacity in absence CD8 + T The provision to Cd8‐/‐ or Rag1‐/‐ mice led restoration cell maturation. Furthermore, co‐culture with induced CD27 convert into mature ‐ cells, whereas blocking interaction CD70 abrogated ability...
Depressive disorder is a mental health caused by the dysfunction of nerve regeneration, neuroendocrine and neurobiochemistry, which frequently results in cognitive impairments disorder. Evidence has shown that resveratrol offers benefits for treatment depressive In present study, therapeutic effects were investigated potential mechanisms mediated analyzed hippocampal neuron cells. The anti‑oxidative stress anti‑inflammatory properties also examined vitro vivo. revealed administration...
Medulloblastoma (MB) is the most common type of brain cancer in pediatric patients. Body fluid biomarkers will be helpful for clinical diagnosis and treatment. In this study, liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to identify specific urine metabolites MB a cohort, including 118 healthy controls, 111 patients, 31 patients with malignant cancer, 51 benign disease, 29 1 week postsurgery 80 month postsurgery. The results showed an apparent separation vs....
This study aimed to investigate the correlation between ultrafiltration rate (UFR) and hemoglobin levels erythropoietin (EPO) response in patients receiving maintenance hemodialysis (MHD). 225 MHD were divided into three groups according UFR: < 10 ml/h/kg, 10–13 >13 ml/h/kg. Clinical parameters prognosis compared among groups. Multiple linear regression analyses conducted. SPSS 26.0 (IBM, Chicago, IL, USA) was used analyze all statistics. The UFR ml/h/kg group older than other (p 0.05). > 13...
T reg cells bearing a diverse antigen receptor repertoire suppress pathogenic and maintain immune homeostasis during their long lifespan. How robust function is determined genetically remains elusive. Here, we investigate the regulatory space of cis-regulatory elements lineage–specifying factor Foxp3. Foxp3 enhancers are known as distinct readers environmental cues controlling cell induction or lineage stability. However, single deficiencies cause mild, if any, dysregulation, leaving key...