A5101926724- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Natural Compounds in Disease Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical studies and practices
- Radiomics and Machine Learning in Medical Imaging
- Chronic Kidney Disease and Diabetes
- Mass Spectrometry Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Sphingolipid Metabolism and Signaling
- Digital Media and Visual Art
- Histone Deacetylase Inhibitors Research
- Machine Learning in Bioinformatics
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Drug-Induced Hepatotoxicity and Protection
- Renal and related cancers
- Pharmacological Effects of Natural Compounds
- Renal Diseases and Glomerulopathies
- E-commerce and Technology Innovations
- Acute Lymphoblastic Leukemia research
- Drug-Induced Adverse Reactions
- Renal cell carcinoma treatment
Guilin Medical University
2018-2025
Beijing Children’s Hospital
2014-2024
Capital Medical University
2014-2024
Guangxi Medical University
2023
Fourth Affiliated Hospital of Guangxi Medical University
2023
Lanzhou University
2023
Tianjin Medical University
2022
Qingdao University
2022
Qingdao Women and Children's Hospital
2022
China National Health Development Research Center
2022
Urine is an important source of biomarkers. A single proteomics assay can identify hundreds differentially expressed proteins between disease and control samples; however, the ability to select biomarker candidates with most promise for further validation study remains difficult. bioinformatics tool that allows accurate convenient comparison all existing related studies markedly aid development this area. In study, we constructed Urinary Protein Biomarker (UPB) database collect urinary...
This study aimed to assess the diagnostic performance of [18F]FAPI-42 PET/CT and compare it with that 2-[18F]FDG in patients differentiated thyroid cancer (DTC) biochemical elevations Tg or anti-Tg antibodies.A total 42 DTC antibodies underwent as part this study; which, 11 additionally within 7 days. Images were semi-quantitatively visually interpreted, quantity, location, uptake values lesions noted. The capacity biomarkers affecting evaluated. In addition, compared, correlation between...
With the help of proteomics technology, human plasma and urine proteomes, which closely represent protein compositions input output kidney, respectively, have been profiled in much greater detail by different research teams. Many datasets accumulated to form "reference profiles" proteomes. Comparing these two proteomes may us understand handling aspect kidney function a way, however, has unavailable until recent advances technology.After removing secreted proteins downstream 2611 1522 were...
Triptolide, the predominant biologically active component of Chinese herb Tripterygium wilfordii Hook f., possesses numerous pharmacological activities, including anti-inflammatory, anti-fertility, anti-neoplastic, and immunosuppressive effects. However, toxicity severe adverse effects, particularly hepatotoxicity, limit clinical application triptolide. Licorice root extract contains various bioactive compounds is potent hepatoprotective. Magnesium isoglycyrrhizinate, a magnesium salt...
Ubiquitin ligases (E3s) confer specificity to ubiquitination by recognizing target substrates. However, the substrates of most E3s have not been extensively discovered, and new methods are needed efficiently comprehensively identify these Mostly, specifically recognize via their protein interaction domains. We developed a novel integrated strategy containing domains on proteomic scale. The binding properties were characterized screening random peptide library using yeast two-hybrid system....
Biomarker is the measurable change associated with a physiological or pathophysiological process. Unlike blood which has mechanisms to keep internal environment homeostatic, urine more likely reflect changes of body. As result, be better biomarker source than blood. However, since urinary proteome affected by many factors, including diuretics, careful evaluation those effects necessary if proteomics used for discovery. Here, we evaluated three commonly-used diuretics (furosemide, F;...
Gastric cancer is a significant global health issue. Celastrol, natural compound, has shown antitumor potential, but its molecular mechanism in gastric remains unclear. In this study, we treated HGC-27 cells with celastrol and employed CCK8, colony formation, Transwell assays, revealing inhibitory effect on cell proliferation migration. Flow cytometry assay results showed that could elevate the level of reactive oxygen species (ROS) cells. By using iron ion malondialdehyde (MDA) detection...
The use of targeted proteomics to identify urinary biomarkers kidney disease in urine can avoid the interference serum proteins. It may provide better sample throughput, higher sensitivity, and specificity. Knowing which proteins target is essential. By analyzing from perfused isolated rat kidneys, 990 origin with human analogs were identified urine. Of these proteins, 128 not found normal become zero background. A total 297 plasma. These will be influenced by other organs specific. levels...
Background: This study proposes a quantitative 2-stage procedure to detect potential drug-induced liver injury (DILI) signals in pediatric inpatients using an electronic health records (EHRs) database. Methods: Eight years of medical data from constructed database were used. A two-stage was adopted: (i) stage 1: the drugs suspected inducing DILI selected and (ii) 2: associations between identified retrospective cohort study. Results: total 1196 initially selected, which 12 potentially as...
Medulloblastoma (MB) is the most common type of brain cancer in pediatric patients. Body fluid biomarkers will be helpful for clinical diagnosis and treatment. In this study, liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to identify specific urine metabolites MB a cohort, including 118 healthy controls, 111 patients, 31 patients with malignant cancer, 51 benign disease, 29 1 week postsurgery 80 month postsurgery. The results showed an apparent separation vs....
Triptolide (TP) has demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carcinoma a high incidence in men, its is increasing year by year. Studies have shown that angiogenesis plays an important role the formation of tumors closely related to tumor growth metastasis. Deregulation sphingolipids signaling been associated with several pathological conditions, including cancer. In present study, we aimed at exploring molecular...
Aim: To profile the plasma proteomics and metabolomics of patients with renal cysts, sporadic angiomyolipoma (S-AML) tuberous sclerosis complex related (TSC-RAML) before after everolimus treatment, to find potential diagnostic prognostic biomarkers as well reveal underlying mechanism TSC tumorigenesis. Materials Methods: We retrospectively measured proteins metabolites from November 2016 2017 in a cohort pre-treatment post-treatment TSC-RAML compared them cyst S-AML by ultra-performance...
Abstract Background Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma with poor prognosis in children. The 5-year survival rate for early RMS has improved, whereas it remains unsatisfactory advanced patients. Urine can rapidly reflect changes body and identify low-abundance proteins. Early screening of tumor markers through urine allows earlier treatment, which associated better outcomes. Methods patients under 18 years old, including those newly diagnosed after surgery, were...
Abstract Objectives To compare the risk of acute kidney injury (AKI) between hospitalized children who received intravenous contrast media for imaging examinations and those did not. Methods This retrospective cohort study enrolled patients aged 0–18 years with serum creatinine levels before after from 2015 to 2020 at Beijing Children’s Hospital. Participants were classified into an exposure group or a control group. Log-binomial regression analysis was used estimate adjusted ratio (aRR)...
Abdominal-type Henoch-Schonlein purpura (HSP) is a common refractory disease in children. Currently, no specific diagnostic biomarker available for HSP.Children with abdominal type HSP were first diagnosed three syndromes using Chinese traditional medicine. The urinary proteomes among the of patients and healthy controls compared two label-free proteomics quantifications, including data-dependent acquisition data-independent acquisition.For comparison between children, total 75 differential...
To appraise the reporting quality of studies which concerned linezolid-related thrombocytopenia referring to REporting Conducted using Observational Routinely collected health Data (RECORD) statement.Medline, Embase, Cochrane library and clinicaltrial.gov were searched for observational concerning routinely data from 2000 2017. Two reviewers screened potential eligible articles extracted independently. Finally, assessment was performed by two senior researchers RECORD statement.Of 25...
Secretome study presents new possibilities for understanding liver secretory function in a comprehensive and exploratory way. Perfusates from isolated perfused rat are good targets secretome on the organ level. There two major concerns this type of study, cytosolic blood contaminations perfusates. Therefore, perfusion conditions were carefully controlled alanine aminotransferase levels perfusates monitored as indicators integrity contamination. The protein pattern perfusate was significantly...
Objectives: This study aimed to develop a procedure explore the adverse drug reaction signals of drug-induced neutropenia (DIN) or agranulocytosis (DIA) in children using an electronic health records (EHRs) database.Methods: A two-stage design was presented. First, suspected drugs induce DIN DIA were selected. Second, associations evaluated by retrospective cohort study.Results: Ten and five potentially identified be associated with DIA, respectively. Finally, (oseltamivir, chlorpheniramine,...