A5100461156- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Pelvic floor disorders treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Dysphagia Assessment and Management
- 3D Printing in Biomedical Research
- Folate and B Vitamins Research
- Ocular Surface and Contact Lens
- Osteoarthritis Treatment and Mechanisms
- Tumors and Oncological Cases
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
- Moyamoya disease diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Sarcoma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Nutrition and Health in Aging
- Ureteral procedures and complications
- Silk-based biomaterials and applications
- Corneal Surgery and Treatments
- Pelvic and Acetabular Injuries
- Soft tissue tumor case studies
Hospital of Hebei Province
2022-2025
Qingdao University
2012-2024
Affiliated Hospital of Qingdao University
2012-2024
Tianjin Medical University General Hospital
2013-2024
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
Chengdu Second People's Hospital
2024
Chengdu Medical College
2024
University of Pittsburgh
2023-2024
Weatherford College
2024
Fibroblast-like synoviocytes (FLS) are important components of the synovial membrane. They can contribute to joint damage through crosstalk with inflammatory cells and direct actions on tissue pathways in rheumatoid arthritis (RA). Recent evidence suggests that, compared FLS normal tissue, RA exhibits significant differences metabolism. metabolomic studies have demonstrated that metabolic changes, including those glucose, lipid, amino acid metabolism, exist before synovitis onset. These...
TCF4, a key transcription factor of Wnt signaling system, has been recently found to be essential for maintaining stem cells. However, its pathway is not well elucidated. This study was explore the functional roles and TCF4 in adult cell properties using human corneal epithelial cells as model. With immunofluorescent staining real-time polymerase chain reaction, we observed that exclusively expressed basal layer limbal epithelium where reside. colocalized with ABCG2 p63, two recognized...
The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disorder. MicroRNAs negatively regulate the expression of target genes at posttranscriptional level by binding to 3′ untranslated region genes. Our previous study showed that miR‐141‐3p was dramatically decreased in ovaries rat PCOS models. In this study, we aimed characterize ovarian granulosa cells. 3‐(4,5‐Dimethylthiazol‐2‐Yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) assay cell viability increased when...
Growth differentiation factor 15 (GDF15) is a secreted protein with pleotropic functions from the transforming growth β (TGF-β) family. GDF15 synthesized as precursor and undergoes proteolytic cleavage to generate mature GDF15. The strong appetite-suppressing effect of makes it an attractive therapeutic agent/target for diseases such obesity cachexia. In addition, clinical studies indicate that circulating, independent biomarker heart failure. We recently found heart-derived hormone inhibits...
Multicellular mesenchymal stem cell (MSC) spheroids possess enhanced chondrogenesis ability and limited fibrosis, exhibiting advantage toward hyaline-like cartilage regeneration. However, because of the surfaces in spheroid exposed to DNA/vector, it is difficult realize efficient gene transfection, most which highly rely on cell-substrate interaction. Here, we report a poly(l-glutamic acid)-based porous scaffold with tunable inner that can sequentially cell-scaffold attachment detachment, as...
Stem-cell-derived organoid can resemble in vivo tissue counterpart and mimic at least one function of or organ, possessing great potential for biomedical application. The present study develops a hydrogel with cell-responsive switch to guide spontaneous sequential proliferation aggregation adipose-derived stem cells (ASCs) without inputting artificial stimulus vitro constructing cartilaginous microtissues enhanced retention cell–matrix cell–cell interactions. Polylactic acid (PLA) rods are...
Rationale: Transverse spinal cord infarction (SCI) is rare but highly disabling. Aortic thrombosis was described as one of the most common etiologies. Thromboembolic complications associated with intravenous immunoglobulin (IVIG) have been reported. Patient concerns: A previously well, 64-year-old man who given treatment IVIG (0.4 g/kg/d for 5 days) exfoliative dermatitis 2 weeks before, progressively developed flaccid paraplegia lower extremities, loss all sensations below T3 level and...
Tissue engineering holds great promise for corneal transplantation to treat blinding diseases. This study was explore the use of natural stroma as an optimal substrate construct a native like equivalent. Human epithelium cultivated from donor limbal explants on stromal discs prepared by FDA approved Horizon Epikeratome system. The morphology, phenotype, regenerative capacity and potential were evaluated hematoxylin eosin immunofluorescent staining, wound healing model, xeno-transplantation...
Toward osteochondral tissue construction, the present study introduced a bilayer scaffold to induce sequential chondrogenesis and osteogenesis of stem cells in vitro. Two scaffolds that are both based on poly(l-glutamic acid) (PLGA) chitosan (CS) were combined form scaffold. The cartilage region was covalently cross-linked PLGA/CS hydrogel with tubular pore structure, possessing swollen network prevent cellular adhesion, while inducing spontaneous aggregate formation. bone electrostatically...
This study aimed to investigate the correlation between ultrafiltration rate (UFR) and hemoglobin levels erythropoietin (EPO) response in patients receiving maintenance hemodialysis (MHD). 225 MHD were divided into three groups according UFR: < 10 ml/h/kg, 10–13 >13 ml/h/kg. Clinical parameters prognosis compared among groups. Multiple linear regression analyses conducted. SPSS 26.0 (IBM, Chicago, IL, USA) was used analyze all statistics. The UFR ml/h/kg group older than other (p 0.05). > 13...
Abstract Aim A complete and non‐splice porcine small‐intestine submucosa (SIS) patch was used for total pelvic anatomical repair of organ prolapse. Methods This study included a 17 patients with severe prolapse, including five combined stress urinary incontinence (SUI). Panhysterectomy performed, then SIS placed on the anterior (posterior) vaginal wall. The top wall moved to corresponding side wall, sutured bilateral uterosacral ligaments, sacrospinous ligament, arcus tendineus fasciae...
Abstract Background Kartagener syndrome is an autosomal recessive inherited disorder of primary ciliary dyskinesia. Moyamoya refers to a moyamoya angiopathy associated with other neurological and/or extra-neurological symptoms, or due well identified acquired cause. We herein reported case 48-year-old woman who was favored the diagnosis and syndrome. The whole genome sequencing bioinformatics analysis showed homozygotic nonsense mutation in dynein, axonemal, heavy chain ( DNAH ) 5 gene,...
Glioblastoma (GBM) is the most common malignant brain tumor in adults. The prognosis of GBM patients poor. Even with active standard treatment, median overall survival only 14.6 months. It therefore critical to ascertain recurrence and search for factors that influence GBM. This study aimed screen variables related progression-free (PFS) (OS) undergoing surgery concurrent chemoradiotherapy, as well propose a nomogram individual risk prediction based on preoperative imaging parameters...
Background & AimsInflammation can increase vitamin B6 uptake and catabolism. Higher turnover (4-pyridoxic acid/pyridoxal 5'-phosphate ratio, 4-PA/PLP) has been associated with mortality risk in the general population. We aimed to investigate association between 4-PA/PLP long-term patients type 2 diabetes mellitus (T2DM), an inflammatory disease.MethodsIn this prospective cohort study from National Health Nutrition Examination Survey (NHANES) cycles 2005-2010, levels of 4-PA PLP plasma were...