A5100777772- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Nutrition and Health in Aging
- Phytochemistry and Biological Activities
- Genetic factors in colorectal cancer
- Traditional Chinese Medicine Analysis
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Drug-Induced Hepatotoxicity and Protection
- Advanced Glycation End Products research
- Mycotoxins in Agriculture and Food
- Neurological Disease Mechanisms and Treatments
- Cancer-related Molecular Pathways
- Reconstructive Surgery and Microvascular Techniques
- Thyroid Cancer Diagnosis and Treatment
- S100 Proteins and Annexins
- Chronic Myeloid Leukemia Treatments
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Forensic and Genetic Research
- Forensic Entomology and Diptera Studies
- Synthesis and bioactivity of alkaloids
- Muscle metabolism and nutrition
Foshan University
2025
Sichuan University
2015-2024
West China Hospital of Sichuan University
2024
West China Medical Center of Sichuan University
2024
Nanjing Medical University
2022-2024
Shanghai University of Traditional Chinese Medicine
2022
Maternal and Child Health Hospital of Sichuan Province
2022
Shuguang Hospital
2022
Ingredion (United States)
2020
Allergan (United States)
2020
Exogenous microparticles including microplastics are novel pollutants that could persist in the environment with potential health effects, while crucial data on their exposure humans still lacking. To understand panorama of and distribution characteristics different kinds body fluids. A non-targeted microparticle internal landscape analysis was done thirteen human enclosed fluids covering eight systems. Totally 104 patients aged 24–96 years an average age 56 were included this study. After...
Appropriate separation and enrichment steps can enhance the performance of SERS assays. For rapid, in-situ detection carbaryl, a novel PA-6/AuNRs@ZIF-8 film that be applied to dual-mode detection, has been developed. In film, PA-6 was used as TLC substrate for initial substance measured. ZIF-8 provides chemical enhancement in well secondary analytes. Utilizing this we have successfully implemented TLC-SERS rapid scheme, resulting limit carbaryl low 1 × 10–9 M lake water 15 min, which is...
Abstract Background Health-related quality of life (HRQoL), which can be influenced by various aspects, especially socioeconomic status and lifestyle, has been identified as an important predictor the prognosis older adults. Dietary habit, a major part affect nutritional status, is closely correlated with development geriatric syndromes in elderly. Aims The aim study was to examine association HRQoL, lifestyle risk severity sarcopenia, syndrome characterized progressive loss skeletal muscle...
Abstract Background With the recent emergence of immune checkpoint inhibitors, microsatellite instability (MSI) status has become an important biomarker for blockade therapy. There are growing technical demands integration different genomic alterations profiling including MSI analysis in a single assay full use limited tissues. Methods Tumor and paired control samples from 64 patients with primary colorectal cancer were enrolled this study, 14 MSI-high (MSI-H) cases 50 stable (MSS)...
To describe the genetic landscape and clinical characteristics of Chinese patients diagnosed with papillary thyroid cancer (PTC) to determine which high-risk suggest a likelihood lymph node metastasis (LNM) lateral (LLNM).Data from previously untreated PTC collected between May 2018 December 2020 14 hospitals in China were analyzed retrospectively. High-risk pathologic defined as T3/T4, N(+), N1b(+) stages. All tested for 57 genes by second-generation sequencing. The t-test, chi-square test,...
To estimate the prevalence of dynapenia and examine potential risk factors for using a sample rural middle-aged elderly Chinese. A cross-sectional study 253 Chinese adults aged 50 years older was conducted from June to August in 2022 Nanjing. questionnaire used collect data on all socioeconomic variables. Body weight, height, body fat percentage, grip strength, waist circumference, calf gait speed were measured. The 69.6 %, 62.3 % men 72.7 women respectively. Binary logistic regressions...
Fumonisin B1 (FB1) is considered the most toxic fumonisin produced by fungi and commonly found in contaminated feed crops. its metabolites extensively exist crops, where FB1-polluted crop ingestion can do harm to livestock poultry, causing poultry intestinal toxicity latter. For investigating FB1-mediated toxicity, we assessed function of FB1 exposure quail intestines explored possible molecular mechanisms. In total, 120 pups were classified into two groups, those control group given a...
Clinical use of autologous fat for correction soft-tissue defects in cosmetic and reconstructive procedures has grown popularity. Graft processing is implicated as one the variable factors affecting quality, viability, subsequent graft survival. This study analyzed vitro physical biologic characteristics lipoaspirate processed using different techniques.Fresh lipoaspirates from patients with informed consent were by 4 methods: decantation, centrifugation, REVOLVE System, PureGraft. Processed...
The stem of Magnoliae officinalis (MO) cortex is always preliminarily processed before being applied in traditional Chinese medicine. definite bioavailability honokiol (HO) and magnolol (MA) MO (PMO) the effect chemical profiling change on pharmacokinetics HO MA are a greater challenge compared with those MO. Compared that MO, pharmacokinetic PMO was significantly changed mean Tmax increased by 31 50% (P < 0.05), respectively; AUC0-t Cmax were 36 24% respectively. Subsequently, investigated...
Aims Previous studies suggested a significant relationship between four surrogate indexes of insulin resistance and subsequent type 2 diabetes mellitus (T2DM). But the association longitudinal changes (denoted as -D ) in CVAI (Chinese visceral adiposity index), LAP (lipid accumulation product), TyG (triglyceride-glucose), TG/HDL-C (triglyceride/ high-density lipoprotein cholesterol) with risk T2DM remained uncertain. We aimed to compare those for predicting middle-aged elderly Chinese....
In this work, a high-speed countercurrent chromatography (HSCCC) method was established for the preparation of phorbol esters (PEs) from Jatropha curcas. n-Hexane–ethyl acetate–methanol–water (1.5:1.5:1.2:0.5, v/v) selected as optimum two-phase solvent system to separate and purify jatropha factor C1 (JC1) with purity 85.2%, determined by HPLC, obtain mixture containing four or five PEs. Subsequently, continuous semipreparative HPLC applied further JC1 (99.8% HPLC). addition, UPLC–PDA...
We proposed a new technique, single-position complete retroperitoneoscopic radical nephroureterectomy (SCRNU), which proved to be efficient for the treatment of upper urinary tract urothelial carcinoma (UTUC).
Microsatellite instability (MSI) is a key biomarker for cancer immunotherapy and prognosis. Integration of MSI testing into next-generation-sequencing (NGS) panel could save tissue sample, reduce turn-around time cost, provide status comprehensive genomic profiling in single test. We aimed to develop an calling model detect along with the NGS panel-based test using tumor-only samples.From January 2019 December 2020, total 174 colorectal (CRC) patients were enrolled, including 31 MSI-high...
Abstract Purpose The transcription factor TBX2 plays a critical role in inner hair cells development mice. Yet, the link between malfunction and human hearing-related disorders remains unexplored. Methods Linkage analysis combined with whole genome sequencing was applied to identify causative gene two autosomal dominant Chinese families characterized by late-onset progressive sensorineural hearing loss incomplete penetrance of horizontal oscillatory nystagmus. Functional evaluation variants...
EP300-ZNF384 fusion is a rare recurrent cytogenetic abnormality associated with B cell acute lymphoblastic leukemia (B-ALL), which was rarely studied in Chinese patient cohort. Here, we used customized RNA gene panel to investigate fusions 56 selected patients without conventional genetic abnormalities. Two forms were detected ten cases, in-frame of EP300 exon 6 fused 3 or 2 ZNF384. The led the lack most functional domains EP300. We firstly reported mixed-phenotype (MPAL) whose CD33 and CD13...
A fast and sensitive HPLC coupled with multivariate analysis was utilized to assist the quality assessment of Gentianae macrophyllae radix (Qinjiao). Seventy-six peaks were separated detected on a fused-core column 35 min. Principal component hierarchical cluster chromatographic data showed that 17 batches Qinjiao could be well categorized into three groups, which closely related origins them. Partial least square-discriminant (PLS-DA) exhibited differentiation might explained by at four...