A5083830451- Paraquat toxicity studies and treatments
- Metabolomics and Mass Spectrometry Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Forensic and Genetic Research
- Genetic Associations and Epidemiology
- Nephrotoxicity and Medicinal Plants
- Mass Spectrometry Techniques and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Bee Products Chemical Analysis
- Peroxisome Proliferator-Activated Receptors
- Molecular Biology Techniques and Applications
- Biosensors and Analytical Detection
- Silymarin and Mushroom Poisoning
- Gout, Hyperuricemia, Uric Acid
- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
- Traditional Chinese Medicine Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Pulmonary Hypertension Research and Treatments
- Genetic Mapping and Diversity in Plants and Animals
- Drug Transport and Resistance Mechanisms
- Methemoglobinemia and Tumor Lysis Syndrome
- Liver Disease Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
Nanjing Medical University
2016-2025
Beijing International Studies University
2025
Institute of Forensic Science
2023
Wuhan Puai Hospital
2021
Huazhong University of Science and Technology
2021
Changzhou No.2 People's Hospital
2016
Appropriate separation and enrichment steps can enhance the performance of SERS assays. For rapid, in-situ detection carbaryl, a novel PA-6/AuNRs@ZIF-8 film that be applied to dual-mode detection, has been developed. In film, PA-6 was used as TLC substrate for initial substance measured. ZIF-8 provides chemical enhancement in well secondary analytes. Utilizing this we have successfully implemented TLC-SERS rapid scheme, resulting limit carbaryl low 1 × 10–9 M lake water 15 min, which is...
BACKGROUND:In clinical practice, some patients might not be able or unwilling to provide a thorough history of medication and poison exposure.The aim this study was use toxicological analysis examine the characteristics acute poisoning with uncertain exposure histories from perspective analysis. METHODS:This retrospective descriptive an institute poisoning.Patient registration information test reports spanning period April 1, 2020 March 31, 2022, were obtained laboratory.The had positive...
Acne vulgaris (AV) is a prevalent inflammatory skin condition that bothers range of people, appearing in lots areas our body. This paper examines the various factors contributing to AV development, including hormone levels, dietary influences, environmental triggers, and stress-related pathways. Through analyzing recent findings on topical oral drug therapies, as well non-invasive treatments such photodynamic therapy, study identifies key reduce different levels scars. Additionally,...
Diquat (DQ), a widely used bipyridyl herbicide, is associated with significantly higher rates of kidney injuries compared to other pesticides. However, the underlying molecular mechanisms are largely unknown. In this study, we identified changes in early stage DQ-induced damage mouse model through transcriptomic, proteomic and metabolomic analyses. We 869 genes, 351 proteins 96 metabolites that were differentially expressed DQ-treated mice relative control (p < 0.05), showed significant...
Abstract Background Exploring the impact of professional identity on academic performance students is crucial for improving teaching effectiveness and educational outcomes in this field. Forensic medicine a niche interdisciplinary discipline medical system. However, current literature development does not adequately address forensic students. Aim This study aimed to assess among students, explore factors associated with identity, determine role shaping students’ learning engagement their...
This study aimed to develop and validate an ultraperformance liquid chromatography-tandem mass spectrometry simultaneously determine diquat (DQ) its two primary metabolites in rat plasma application the toxicokinetic study.The chromatographic separation of DQ was performed with hydrophilic interaction chromatography column by adding formic acid ammonium acetate mobile phase stepwise elution mode. were detected positive mode.The lower limit quantification ranging from 0.3 3.0 ng/mL for...
Paraquat (PQ) is a widely used herbicide which can cause high mortality to humans. However, relatively few studies focus on metabolic feature of PQ intoxication for investigating the underlying mechanisms. Here we performed non-targeted metabolomics profiling serum samples from acute and chronic intoxicated mouse models by gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) identify characteristic metabolites intoxication. Results showed that 3-indolepropionic acid (IPA) pathway...
Paraquat (PQ) is a widely used herbicide and common cause of poisoning that leads to pulmonary fibrosis with high mortality rate. However, the underlying mechanisms PQ-induced whether epithelial cell senescence involved in process remain elusive. In this study, Hippo-YAP/TAZ activation were observed both C57BL/6 mice human cells. senescent cells promoted lung fibroblast transformation through secreting senescence-associated secretory phenotype (SASP) factors. Yap/Taz knockdown lungs...
ToF-SIMS, PCA and PLS-DA were combined to compare lipid profiles of myocardial tissue in sudden cardiac death normal, mice humans. SIMS imaging was utilized correlate the composition structural changes.