A5076928955- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Influenza Virus Research Studies
- Respiratory viral infections research
- Kruppel-like factors research
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Salivary Gland Disorders and Functions
- Neonatal Respiratory Health Research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Pneumonia and Respiratory Infections
- Ferroptosis and cancer prognosis
- Inflammation biomarkers and pathways
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Acute Myeloid Leukemia Research
- Bioinformatics and Genomic Networks
- Natural Compounds in Disease Treatment
- Skin Diseases and Diabetes
First Affiliated Hospital of Jinan University
2016-2024
Jinan University
2021
Sun Yat-sen University
2011-2013
The First Affiliated Hospital, Sun Yat-sen University
2011-2013
Central South University
2009-2010
Xiangya Hospital Central South University
2009-2010
Frailty is common and not limited to older age group. Serum α-Klotho works as a biomarker of anti-aging effect. However, there research about the relationship between them in middle-aged people controversy still exists.Based on data from National Health Nutrition Examination Survey (NHANES) 2007-2016, we constructed weighted logistic regression models conducted sensitivity tests investigate correlation frailty among aged 40 79. And then their was visualized by Restricted Cubic Spline (RCS)....
Acute kidney injury (AKI) may develop in patients with coronavirus disease 2019 (COVID-19) and is associated in-hospital death. We investigated the incidence of AKI 223 hospitalized COVID-19 analyzed influence factors AKI. The cytokine storm syndrome its correlation other clinicopathologic variables were also investigated. retrospectively enrolled adult virologically confirmed who at three hospitals Wuhan Guizhou, China between February 13, 2020, April 8, 2020. included 124 moderate 99...
Chronic obstructive pulmonary disease (COPD) is associated with a complex inflammatory regulatory network. Resistin-like molecule β (RELMβ) highly expressed in the lungs of COPD patients. We aimed to investigate proinflammatory effect RELMβ on airway epithelial cells COPD.First, GEO dataset was used analyze expression gene and control groups as well protein levels sera outpatients normal subjects our hospital. also stimulated 16HBE bronchial recombinant analyzed IL-8 IL-1β. upregulated...
Lung cancer is the most common malignant tumor, and it has a high mortality rate. However, study of miRNA-mRNA regulatory networks in plasma patients with non-small cell lung (NSCLC) insufficient. Therefore, this explored differential expression mRNA miRNA NSCLC patients.The Gene Expression Omnibus (GEO) database was used to download microarray datasets, differentially expressed miRNAs (DEMs) were analyzed. We predicted transcription factors target genes DEMs by using FunRich software...
Long non-coding RNAs (lncRNAs), a class of endogenous RNAs, play an important role in the development and metastasis non-small cell lung cancer (NSCLC). However, function mechanism action long intergenic non-protein coding RNA 1089 (LINC01089) NSCLC remains unclear. This study aimed to identify LINC01089 proliferation, migration, invasion NSCLC.Expression relationship between overall survival (OS) were determined using GEPIA 2.0. Similarly, microRNAs (miRNAs) that showed increased expression...
Currently, the precise mechanism by which N6 -methyladenosine (m6A) modification of long non-coding RNAs (lncRNAs) promotes occurrence and development lung squamous cell carcinoma (LUSC) influences tumor microenvironment (TME) remains unclear. Therefore, we studied prognostic value m6A-related lncRNAs their relationship with TME in 495 LUSC samples from The Cancer Genome Atlas (TCGA) database. Pearson's correlation univariate Cox regression analysis identified 6 values for patients. patients...
Krüppel-like factor 17 (KLF17) has been reported to be involved in invasion and metastasis suppression lung cancer, but the molecular mechanisms underlying anti-invasion anti-metastasis roles of KLF17 cancer are not fully illustrated. Here, we showed that inhibited A549 H322 cells; effect was associated with urokinase plasminogen activator (uPA/PLAU) expression. can bind promoter uPA inhibit its Enforced expression abrogated cells. In addition, immunohistochemistry staining protein...
Acute myeloid leukemia (AML) is a common hematopoietic malignancy and have unsatisfactory prognosis. Our study aimed to identify hub genes in AML explore potential biomarkers through integrated bioinformatics.Microarray datasets were analyzed screen the differentially expressed (DEGs). Functional enrichment analysis was performed, protein-protein interaction (PPI) network generated by STRING (11.0) database Cytoscape (3.7.2) software. Hub screened verified GEPIA2 GEO microarray database....
We aim to identify the common genes, biological pathways, and treatment targets for primary Sjögren’s syndrome patients with varying degrees of fatigue features. select datasets about transcriptomic analyses (pSS) different features normal controls in peripheral blood. differentially expressed genes (DEGs) find shared pathways pSS design a protein-protein interaction (PPI) network by some practical bioinformatic tools. And hub are detected based on PPI network. perform pathway analysis Gene...
Chronic obstructive pulmonary disease (COPD) is prevalent mainly in older adults, especially those who are smokers. It appears to be regulated by multiple genes, but there some degree of familial clustering. The evidence date suggests that COPD-associated biomarkers largely inadequate for diagnosis, so we conducted a comprehensive search more specific genetic markers.We used 3 datasets from the Gene Expression Omnibus (GEO) database. By investigating biological information [i.e., Ontology,...
This study was conducted to investigate the risk factors for pulmonary abscess-related empyema by investigating clinical characteristics and chest computed tomography imaging features of patients with abscesses.We retrospectively analyzed findings 101 cases abscess, including 25 (the experimental group) 76 no control group). The potential were compared between groups using univariate multivariate logistic regression analyses.The incidence 24.8% (25/101). Univariate analysis showed that male...
Research in this article was performed to explore the biological role and clinical significance of Krüppel-like transcription factor 6 (KLF6) non-small-cell lung cancer (NSCLC). KLF6 expression NSCLC cell lines analyzed using reverse PCR Western blot. The expressed protein examined 50 surgical tissues immunohistochemistry. Statistical analyses were employed for association examinations. CCK8 assay Annexin V/PI analysis used execute proliferation apoptosis KLF6-overexpression control groups....
Objectives: This study analyzed the clinical characteristics and hematologic examination indexes to tell type of influenza among patients provide a basis for early diagnosis treatment patients. Methods: We collected demographic data from 726 impact different manifestations hematological tests on measured values types. Results: The common were fever (99.2%), pharyngeal congestion (97.1%) cough (80.4%), et al. Those with oneset illness 19-49 years age (OR= 0.335, 95% CI: 0.196-0.573) or had...
This study aimed to explore the risk factors for mediastinal lymph node metastases (MLNM) in patients with early-stage non-small-cell lung cancer (NSCLC) and establish a predictive model. A retrospective analysis was conducted on clinical data from NSCLC treated at Second Affiliated Hospital of Guangzhou Medical University First Dongguan Guangdong between March 2021 2023. Baseline data, laboratory parameters, pathological features were collected analyzed. Univariate multivariate logistic...
Small-cell lung cancer (SCLC) is a poorly differentiated neuroendocrine tumor with endocrine function. For decades, chemotherapy and immune checkpoint inhibitors (ICIs) have been the first-line treatment options. Because of its ability to normalize vessels, anlotinib recommended as novel therapy third-line treatment. A combination anti-angiogenic drugs ICIs can effectively safely benefit advanced patients. However, immune-related side effects caused by are common. Hepatitis B virus (HBV)...
COVID-19 is still prevalent in more world regions and poses a severe threat to human health due its high pathogenicity. The incidence of COPD patients gradually increasing, especially over 45 years old. are susceptible the specific lung receptor ACE2 SARS-CoV-2. We attempt reveal genetic basis by analyzing expression common DEGs two diseases through bioinformatics approaches find potential therapeutic agents based on target genes. Thus, we search GEO database for transcriptomic gene...
Lung adenocarcinoma is a form of non-small-cell lung cancer with high mortality in the advanced stages, and one most common histological subtypes countries. Prognosis generally poor, median survival 4-13 months. We report case unusually prolonged patient complicated by hypothyroidism. A 71-year-old man stage IV presented Surprisingly, without any anti-tumor anti-hypothyroidism therapy, he survived this for longer than 2.5 years before his last follow-up visit. Patients rarely survive 2...