A5016190451- Catalytic Cross-Coupling Reactions
- Molecular Sensors and Ion Detection
- Catalytic C–H Functionalization Methods
- Sulfur Compounds in Biology
- Robotic Path Planning Algorithms
- Soft Robotics and Applications
- Advanced Photocatalysis Techniques
- Animal Genetics and Reproduction
- Animal Diversity and Health Studies
- Cyclopropane Reaction Mechanisms
- Luminescence and Fluorescent Materials
- Microbial Metabolic Engineering and Bioproduction
- Milk Quality and Mastitis in Dairy Cows
- Control and Dynamics of Mobile Robots
- Robotic Locomotion and Control
- Biofuel production and bioconversion
- Perovskite Materials and Applications
- Analytical Chemistry and Sensors
- PI3K/AKT/mTOR signaling in cancer
- Modular Robots and Swarm Intelligence
- Chromatography in Natural Products
- Meat and Animal Product Quality
- Diphtheria, Corynebacterium, and Tetanus
- Silkworms and Sericulture Research
- Veterinary medicine and infectious diseases
Zhengzhou University
2025
University of Illinois Urbana-Champaign
2024
East China Normal University
2003-2024
Qiqihar University
2023-2024
Southeast University
2023
Southwest University of Science and Technology
2022
Northwest A&F University
2020-2022
Shanghai American School
2022
Nanjing University of Chinese Medicine
2019-2020
Agriculture and Forestry University
2020
Cholesterol crystals (CCs) are major contributors to atherosclerosis and gallstones development. Understanding their emergence, polymorphic variations, morphological intricacies, molecular interactions of CCs pivotal for unraveling associated maladies. We...
Cutaneous melanoma (CM) is an aggressive skin cancer with high metastatic potential and poor prognosis. Splicing factors, which regulate pre-mRNA alternative splicing (AS) events, have been suggested as therapeutic targets in CM. The objective of this study was to identify candidate factors involved CM through a systems biology approach elucidate their roles progression. 390 AS events associated patient survival were identified using bivariate Cox regression receiver operating characteristic...
The elusive rhodium-catalyzed Heck-type coupling of arylboronic acids with alpha,beta-unsaturated esters is effected using rhodium chloride as catalyst, indicating the hydrolysis Rh-C bond could be finely tuned by steric environment around rhodium.
Histone deacetylases (HDACs), a critical family of epigenetic enzymes, has emerged as promising target for antitumor drugs. Here, we describe our protocol virtual screening in identification novel potential HDAC inhibitors through pharmacophore modeling, 3D-QSAR, molecular docking and dynamics (MD) simulation. Considering the limitation current works, drug repurposing strategy was applied to discover druggable inhibitor. The ligand-based 3D-QSAR models were established, their reliability...
Abstract Wall-climbing robot (WCR) displays a great potential in wide range of tasks that are challenging or dangerous for human presence. Adhesion capacity and control mechanism the key factors climbing robots, as they directly affect robot’s durability power consumption different tasks. However, many WCRs adopting negative pressure adhesion rely on extra such air compressor to achieve engagement disengagement while overlooking dimension energy-consumption level robot. The high...
The methanol extract of the tubers Polygonum perfoliatum L. afforded a new lignan: 8-oxo-pinoresinol (1), and five known compounds 3′,5-dihydroxy-3,4′,5′,7-tetramethoxy-flavone (2), catechin (3), quercetin (4), quercetin-3-O-β-D-glucuronide (5) rutin (6). Their structures were established by MS, one- two-dimensional NMR experiments. Compound 1 showed cytotoxicity against human mammary carcinoma (Bcap-37), colon (RKO), hepatocellular (SMMC-7721), prostate (PC3) erythroleukaemia (K562) cells.
Distortion of silicon in coumarin skeletons offers ultrahigh environment-sensitive fluorophores that show more than a 200 nm shift different solvents.
Circular RNAs (circRNAs), which are considered a large class of endogenous noncoding RNAs, function as regulators in various biological procedures. In this study, the and molecular mechanisms circRNA8220 goat mammary epithelial cells (GMECs) were explored. CircRNA8220 could spong miR-8516 block by binding to target site negative feedback relationship existed between miR-8516. Stanniocalcin 2 (STC2) was gene up-regulate expression STC2 sponging GMECs. circRNA8220/miR-8516/STC2 promote...
Abstract Existing magnetically driven soft robots mainly rely on external electromagnetic, leading to a substantial energy consumption due the requirement of large magnetic field. Moreover, precise control these relies electric current, making them highly susceptible disturbances and deviations induced by minute variations in current. To overcome challenges, we propose evaluate novel approach employing miniature walking robot empowered its internal electromagnets. The overall size is 18 mm ×...
Myocontrol is the intuitive control of a neural prosthetic via user's voluntary muscular activations detected in form surface EMG(electromyography) signals. This type usually implemented by means pattern recognition, which uses set training data to create machine learning model that can decipher these electrical activations. EMG myocontrol now widely used multiple fields such as clinical medicine and human-computer interfacing. However, usefulness depends greatly on accuracy collected...
Protein phosphatase 1 (PP1) is a critical regulator of several processes, such as muscle contraction, neuronal signaling, glycogen synthesis, and cell proliferation. Dysregulation PP1 has recently been found to be implicated in cardiac dysfunctions, which indicates that could an attractive therapeutic target. However, discovery inhibitors with satisfied safety efficiency still challenge. Here, order discover potential inhibitors, compounds extracted from traditional Chinese medicine (TCM)...
Goat milk in some cases is less allergenic than cow milk, therefore, more people drink goat the world, so it necessary for us to improve yield and quality of milk. Previous studies have shown that genes are closely related lactation. Ovarian cancer G protein-coupled 1 (OGR1) a receptor discovered recently. OGR1 widely found various tissues organisms involved cell skeleton reorganization, carcinogenesis, proliferation, apoptosis by regulating multiple signaling pathways cells. However,...
Corynebacterium pseudotuberculosis (C. pseudotuberculosis) is a zoonotic chronic infectious disease. It mainly occurs in dairy goats reared herds, and once it invades the goats, difficult to completely remove it, causing great harm development of sheep industry. This study was based on TMT-based quantitative proteomics RNA-seq methods measure spleen samples infected at different time periods. Nine four-month-old were divided into three groups, with each group. The first group (NC group)...
Acridinium benzoate was developed as a unique ICT-based fluorescent scaffold for both ratiometric and turn-on fluorescence imaging through decaging of the phenolic hydroxyl groups. Two probes, Acr1-H2 O2 Acr1-β-gal, were H2 β-galactosidase in vivo.