A5032886888- Traditional Chinese Medicine Analysis
- Molecular Sensors and Ion Detection
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Pesticide Residue Analysis and Safety
- Medicinal Plant Pharmacodynamics Research
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Phosphorus and nutrient management
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Retinal Development and Disorders
- Analytical Chemistry and Sensors
- Sulfur Compounds in Biology
- MicroRNA in disease regulation
- Berberine and alkaloids research
- Advanced Nanomaterials in Catalysis
- Ginkgo biloba and Cashew Applications
- Layered Double Hydroxides Synthesis and Applications
- Mass Spectrometry Techniques and Applications
Chinese Academy of Sciences
2012-2025
University of California, Los Angeles
2025
Ningbo Institute of Industrial Technology
2025
Qingdao National Laboratory for Marine Science and Technology
2020-2023
Institute of Oceanology
2016-2023
Zhengzhou University of Industrial Technology
2023
East China Normal University
2008-2022
Qingdao University of Science and Technology
2010-2022
Hohai University
2021-2022
Chang'an University
2019-2021
<i>Panax notoginseng</i> (Sanqi) is a cardiovascular herb containing ginsenosides that are believed to be responsible for the therapeutic effects of Sanqi. The aim this study was evaluate rat exposure after oral administration Sanqi extract and identify key factors affecting their absorption disposition. Ginsenosides were administered rats, either in form or as pure chemicals. Ra<sub>3</sub>, Rb<sub>1</sub>, Rd, Re, Rg<sub>1</sub>, notoginsenoside R<sub>1</sub> major saponins present herbal...
Extracellular vesicles (EVs) are cell-derived microparticles present in most body fluids, mainly including microvesicles and exosomes. EV-harbored proteins have emerged as novel biomarkers for the diagnosis prediction of different cancers. We successfully isolated exosomes from human saliva, which were further characterized comprehensively. Salivary EV protein profiling normal subjects lung cancer patients was systematically compared through utilizing LC–MS/MS-based label-free...
This study aims to investigate the suitability of thermosensitive triblock polymer poly-(DL-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA as a matrix material for ocular delivery dexamethasone acetate (DXA).The copolymer was synthesized and evaluated its gelation properties. DXA in situ gel-forming solution based on PLGA-PEG-PLGA 20% (w/w) prepared pharmacokinetics rabbit according microdialysis method, which compared normal eye drop.The with had low critical...
Cardiotonic pills are a type of cardiovascular herbal medicine. To identify suitable pharmacokinetic (PK) marker(s) for indicating systemic exposure to cardiotonic pills, we examined the in vivo PK properties putatively active phenolic acids from component herb Danshen (<i>Radix Salviae miltiorrhizae</i>). We also performed vitro and silico assessments permeability solubility. Several were investigated, including tanshinol (TSL); protocatechuic aldehyde (PCA); salvianolic A, B, D; rosmarinic...
Flavonols and terpene lactones are putatively responsible for the properties of Ginkgo biloba leaf extracts that relate to prevention treatment cardiovascular disease cerebral insufficiency. Here, we characterized rat systemic exposure these ginkgo compounds after dosing, as well compounds' pharmacokinetics.Rats received single or multiple doses ShuXueNing injection (prepared from GBE50 intravenous administration) (a standardized extract G. leaves oral administration). Brain delivery was...
The proteins expressed on exosomes have emerged as promising liquid-biopsy biomarkers for cancer diagnosis. However, molecular profiling of exosomal remains technically challenging. Herein, we report a nanozyme-assisted immunosorbent assay (NAISA) that enables sensitive and rapid multiplex proteins. This NAISA system is based the installation peroxidase-like nanozymes onto phospholipid membranes exosomes, thus avoiding need post-labelling detection antibodies. are determined by...
Abstract Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve potential source for cancer biomarkers. As an attractive with merit non-invasiveness, human saliva is a unique medium clinical diagnostics. Thus, we proposed facile approach to prepare salivary extracellular (SEVs). Affinity...
Previous studies have suggested that pathological α-synuclein (α-Syn) mainly transmits along the neuronal network, but several key questions remain unanswered: (1) How many and which connections in connectome are necessary for predicting progression of α-Syn? (2) to identify risk gene affects pathology spreading functioning at presynaptic or postsynaptic regions, these genes enriched different cell types? Here, we addressed with novel mathematical models. Strikingly, α-Syn is predominantly...
Here we report on the identification of peptides targeting X-inhibitor apoptosis protein (XIAP). XIAP functions as a caspase inhibitor and is member inhibitors (IAP) family proteins. IAPs are often overexpressed in cancers leukemias associated with an unfavorable clinical prognosis. We have selected from phage library by using recombinant full-length human or fragment containing only baculovirus IAP repeat 2 (BIR2) domain. A consensus motif, C(D/E/P)(W/F/Y)-acid/basic-<i>X</i>C, was...
Abstract A simple, rapid and reliable liquid chromatography–electrospray ionization tandem mass spectrometry method was established validated for the determination of methotrexate in human plasma. After a straightforward protein precipitation by acetonitrile–water (70:30, v/v), (MTX) p ‐aminoacetophenone (used as internal standard, IS) were separated on Column C 18 column (50 × 2.1 mm, 3 µm; Technology, Fremont, CA, USA) using gradient elution with mobile phase acetonitrile 0.03% acetic acid...
The bacterial colonization of surfaces and subsequent biofilm formation are a great threat in medical therapy clinical diagnosis. complex internal structure composition sets an enormous obstacle for the localization removal biofilms. In this study, we proposed novel biofilm-targeted nanocontainer with successive responsive property toward pH ATP precise simultaneous eradication, acidic adenosine triphosphate (ATP)-rich microenvironment within biofilms, formed due to accumulation fatty acids...
Extracts from Ginkgo biloba leaves confer their therapeutic effects through the synergistic actions of flavonoid and terpenoid components. We herein describe development an LC-MS/MS-based method for simultaneous determination flavonoids (quercetin, kaempferol, isorhamnetin) terpenoids (bilobalide, ginkgolides A, B, C, J) in acid-hydrolyzed plasma by circumventing cross-interference between identified. Notably, inclusion ammonium formate (0.2 mM) mobile phase generated beneficial...