A5031185955- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Cancer Research and Treatment
- RNA modifications and cancer
- Mathematical Biology Tumor Growth
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Multiple Myeloma Research and Treatments
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Neonatal Health and Biochemistry
Second Hospital of Shandong University
2025
Weifang Medical University
2013-2024
Cleveland Clinic
2008-2017
Institute for Stem Cell Biology and Regenerative Medicine
2015
Cancer Institute (WIA)
2014
University of Chicago
2010
University of Rochester Medical Center
2004-2005
University of Rochester
2005
University of Illinois Chicago
2000-2003
Ontario Institute for Cancer Research
1995-2000
Nucleophosmin (NPM1) is among the most frequently mutated genes in acute myeloid leukemia (AML). It not known, however, how resulting oncoprotein mutant NPM1 leukemogenic. To reveal cellular machinery which participates cells, we analyzed endogenous protein interactome by mass spectrometry and discovered abundant amounts of master transcription factor driver monocyte lineage differentiation PU.1 (also known as SPI1). Mutant NPM1, aberrantly accumulates cytoplasm, dislocated into cytoplasm...
Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron-dependent lipid peroxidation. Though multiple genes (including SLC7A11 GPX4) have been demonstrated to play key roles in ferroptosis, little known about the epigenetic regulation this process. Here, we report that KDM3B, histone H3 lysine 9 demethylase, can protect against ferroptosis induced Erastin, an inhibitor SLC7A11. KDM3B overexpression HT-1080 cells results decreased methylation. Furthermore,...
We describe here the tyrosine kinase activity of human biliverdin reductase (BVR) and its potential role in insulin-signaling pathway. BVR is both a substrate for insulin receptor (IR) (IRK) serine phosphorylation IR 1 (IRS-1). Our previous studies have revealed serine/threonine BVR. Y 198 , YMKM motif found C-terminal domain BVR, shown to be insulin-activated IRK. This IRS proteins provides docking site that contain Src homology 2 domain. Additionally, 228 YLSF sequence 291 are IRK...
Acute myeloid leukemia (AML) is one of the malignant hematological cancers with high mortality. Finding a more effective and readily available treatment utmost importance. Here, we aimed to identify anti-leukemia effect natural small molecule compound honokiol on panel AML cell lines, including THP-1, U-937, SKM-1, explored honokiol's potential biological pathways mechanisms. The results showed that decreased viability targeted cells, induced their cycle arrest at G0/G1 phase, inhibited...
The present study aimed to investigate the anti‑leukemic effects of dihydroartemisinin (DHA) on T‑cell acute lymphoblastic leukemia (T‑ALL) cell lines, Jurkat and Molt‑4, underlying mechanisms. Cell Counting Kit‑8 was performed measure viability. apoptosis cycle distribution were assessed by flow cytometry. expression levels ATF4 CHOP mRNA reverse transcription‑quantitative PCR, while protein abundance SLC7A11, GPX4, determined western blotting. Moreover, malondialdehyde, glutathione (GSH)...
Biliverdin IXalpha reductase (BVR) catalyzes reduction of the HO activity product, biliverdin, to bilirubin. hBVR is a serine/threonine kinase that contains bZip domain. Presently, regulation gene expression by was examined. 293A cells were infected with adenovirus-doxycycline (Ad-Dox)-inducible cDNA. High level determined at mRNA, protein, and levels 8 h after induction. Cell signal transduction microarray analysis or control Ad-inverted (INV)-hBVR vector identified ATF-2 among several...
Apoptosis genes, such as TP53 and p16/CDKN2A, that mediate responses to cytotoxic chemotherapy, are frequently nonfunctional in melanoma. Differentiation may be an alternative apoptosis for inducing melanoma cell cycle exit. Epigenetic mechanisms regulate differentiation, DNA methylation alterations associated with the abnormal differentiation of cells. The effects deoxycytidine analogue decitabine (5-aza-2'-deoxycytidine), which depletes methyl transferase 1 (DNMT1), on were examined....
As one of the most promising means to repair diseased tissues, stem cell therapy with immense potential differentiate into mature specialized cells has been rapidly developed. However, clinical application stem-cell-dominated regenerative medicine was heavily hindered by loss pluripotency during long-term in vitro expansion. Here, a composite three-dimensional (3D) graphene-based biomaterial, denoted as GO-Por-CMP@CaP, hierarchical pore structure (micro- macropore), developed guide...
The most frequent chromosomal structural loss in hepatocellular carcinoma (HCC) is of the short arm chromosome 8 (8p). Genes on remaining homologous chromosome, however, are not recurrently mutated, and identity key 8p tumor-suppressor genes (TSG) unknown. In this work, analysis minimal commonly deleted segments to identify candidate TSG implicated GATA4, a master transcription factor driver hepatocyte epithelial lineage fate. murine model, liver-conditional deletion 1 Gata4 allele model...
Histone demethylases are promising therapeutic targets as they play fundamental roles for survival of Mixed lineage leukemia rearranged acute ( MLL r AL). Here we focused on the catalytic Jumonji domain histone H3 lysine 9 (H3K9) demethylase JMJD1C to screen potential small molecular modulators from 149,519 natural products and 33,765 Chinese medicine components via virtual screening. inhibitor 4 (JDI‐4) JDI‐12 that share a common structural backbone were detected within top 15 compounds....
Abstract The cytosine analogue decitabine alters hematopoietic differentiation. For example, treatment increases self-renewal of normal stem cells. mechanisms underlying decitabine-induced shifts in differentiation are poorly understood, but likely relate to the ability deplete chromatin-modifying enzyme DNA methyltransferase 1 (DNMT1), which plays a central role transcription repression. HOXB4 is factor that promotes cell self-renewal. In precursors induced differentiate by...
KDM3B reportedly shows both tumor-suppressive and tumor-promoting activities in leukemia. The function of is likely cell-type dependent its seeming functional discordance may reflect phenotypic dependence on downstream targets. Here, we first showed the underexpression acute myeloid leukemia (AML) patients AML cell lines with MLL-AF6/9 or PML-RARA translocations. Overexpression repressed colony formation line 5q deletion. We then performed global microarray profiling to identify potential...