A5004215656- Nanoparticle-Based Drug Delivery
- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Characterization and Applications of Magnetic Nanoparticles
- 3D Printing in Biomedical Research
- Radiomics and Machine Learning in Medical Imaging
- Microfluidic and Bio-sensing Technologies
- Blood properties and coagulation
- Alcoholism and Thiamine Deficiency
- Digital Radiography and Breast Imaging
- Bone Tissue Engineering Materials
- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Micro and Nano Robotics
- Advances in Oncology and Radiotherapy
- Protease and Inhibitor Mechanisms
- Biochemical Acid Research Studies
- Radiology practices and education
- Ultrasound and Hyperthermia Applications
- Metabolism and Genetic Disorders
- Graphene and Nanomaterials Applications
- Venous Thromboembolism Diagnosis and Management
- Electrohydrodynamics and Fluid Dynamics
- Aldose Reductase and Taurine
Northwestern University
2024
University of Chicago
2006-2012
University of Chicago Medical Center
2007
University of Rochester Medical Center
2004-2005
University of Rochester
2005
Cellular purines, particularly adenosine 5'-triphosphate (ATP), fuel many metabolic reactions, but less is known about the direct effects of pyrimidines on cellular metabolism. We found that pyrimidines, not maintain pyruvate oxidation and tricarboxylic citric acid (TCA) cycle by regulating dehydrogenase (PDH) activity. PDH activity requires sufficient substrates cofactors, including thiamine pyrophosphate (TPP). Depletion decreased TPP synthesis, a reaction carried out kinase 1 (TPK1),...
We describe here the tyrosine kinase activity of human biliverdin reductase (BVR) and its potential role in insulin-signaling pathway. BVR is both a substrate for insulin receptor (IR) (IRK) serine phosphorylation IR 1 (IRS-1). Our previous studies have revealed serine/threonine BVR. Y 198 , YMKM motif found C-terminal domain BVR, shown to be insulin-activated IRK. This IRS proteins provides docking site that contain Src homology 2 domain. Additionally, 228 YLSF sequence 291 are IRK...
Biliverdin IXalpha reductase (BVR) catalyzes reduction of the HO activity product, biliverdin, to bilirubin. hBVR is a serine/threonine kinase that contains bZip domain. Presently, regulation gene expression by was examined. 293A cells were infected with adenovirus-doxycycline (Ad-Dox)-inducible cDNA. High level determined at mRNA, protein, and levels 8 h after induction. Cell signal transduction microarray analysis or control Ad-inverted (INV)-hBVR vector identified ATF-2 among several...
A novel method of highly sensitive quantitative detection magnetic nanoparticles (MP) in biological tissues and blood system has been realized tested real time vivo experiments. The is based on nonlinear properties MP the related device can record a very small relative variation susceptibility up to 10−8 at room temperature, providing sensitivity several nanograms 0.1ml volume. Real-time measurements dynamics concentration flow have performed. catheter that carried rat passed through...
We report a simplified single emulsion (oil-in-water) solvent evaporation protocol to synthesize surface functionalized biocompatible magnetic nanospheres by using highly concentrated hydrophobic magnetite (gel) and mixture of poly(D,L lactide-co-glycolide) (PLGA) poly(lactic acid-block-polyethylene glycol-maleimide) (PLA-PEG-maleimide) (10:1 mass) polymers. The as-synthesized particles are approximately spherical with an average diameter 360-370 nm polydispersity index 0.12-0.18,...
A magnetically based detoxification system is being developed as a therapeutic tool for selective and rapid removal of biohazards, i.e. chemicals radioactive substances, from human blood. One the key components this portable magnetic separator capable separating polymer-based nano/micro-spheres arterial blood flow in an ex vivo unit. The consists array alternating parallel capillary tubing magnetizable wires, which exposed to applied field created by two permanent magnets such that...
Purpose: The clinical imaging infrastructure has been designed for the consistent execution of standard‐of‐care examinations. Many protocols research, however, have unique requirements that may burden established infrastructure. Our purpose was to develop a solution many demands and challenges presented by research.Methods: We created Human Imaging Research Office (HIRO) at our institution. HIRO is responsible coordinating acquisition, collection, analysis, maintenance images related data...