A5101605101- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Bladder and Urothelial Cancer Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Head and Neck Anomalies
- Cancer Diagnosis and Treatment
- Botany and Plant Ecology Studies
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Rangeland and Wildlife Management
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Beijing Shijitan Hospital
2019-2024
Capital Medical University
2019-2024
Sino Biopharmaceutical (China)
2024
National Clinical Research
2020-2024
Shanxi University
2019-2023
Shanxi Academy of Medical Sciences
2023
Shanxi Medical University
2023
South China University of Technology
2021-2023
Guangzhou Medical University
2021-2023
Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may associated with the proliferation metastasis of GC. It reported that LSD1 repressed tumor immunity through programmed cell death ligand (PD-L1) melanoma breast cancer. The role immune microenvironment GC is unknown.Expression PD-L1 patients was analyzed by immunohistochemical (IHC) Western blotting. Exosomes were isolated from culture medium cells using an...
Resistance to 5-Fluorouracil (5-Fu) chemotherapy is the main cause of treatment failure in cure colon cancer. Therefore, there an urgent need explore a safe and effective multidrug resistance reversal agent for colorectal cancer, which would be great significance improving clinical efficacy. The dietary flavonoid kaempferol plays key role progression cancer 5-Fu resistance. However, molecular mechanism reversing human cells still unclear. We found that could reverse drug HCT8-R 5-Fu,...
Inflammatory bowel disease (IBD) is a complex characterized by relapsing episodes of inflammation the colonic mucosa. Research into IBD suggests that this condition caused alterations in resident mucosal bacterial populations. Our previous study showed Coprococcus was significantly elevated during improvement IBD. Human metagenome database GMrepo also indicates Coprococcus, particular, eutactus (C. eutactus), which negatively associated with The current implied alleviated effects and...
Cancer stem-like cells (CSC) are thought to drive tumor initiation, metastasis, relapse, and therapeutic resistance, but their specific pathogenic characters in many cancers, including non-small cell lung cancer (NSCLC), have yet be well defined. Here, we develop findings that the growth factor HGF promotes CSC sphere formation NSCLC populations. In patient-derived sphere-forming assays (PD-SFA) with HGF, CD49f CD104 were defined as novel markers of (LCSC). particular, isolated a...
The action mechanism of long non-coding ribonucleic acid-homeobox transcript antisense acid (lncRNA-HOTAIR) in the regulation Wnt signaling pathway on drug resistance non-small cell lung cancer was investigated. Forty eight patients with cancer, who were treated cisplatin (DDP) as neoadjuvant chemotherapy, selected from specimen bank Department Pathology Peking Union Medical College Hospital. Reverse transcription-polymerase chain reaction (RT-PCR) used to detect messenger RNA (mRNA) level...
The recurrence and metastasis of children with mediastinal neuroblastoma (NB) are also occurred after surgery, chemotherapy, or radiotherapy. Strategies targeting the tumor microenvironment have been reported to improve survival; however, thorough investigations monocytes tumor-associated macrophages (Mϕs) specialized functions in NB still lacking. Our data first demonstrated polypyrimidine tract binding protein 2 (PTBP2) as a possible identifier patients screened by proteomic profiling that...
Previous studies of transgenerational plasticity have demonstrated that long-term overgrazing experienced by Leymus chinensis, an ecologically dominant, rhizomatous grass species in eastern Eurasian temperate grassland, significantly affects its clonal growth subsequent generations. However, there is a dearth information on the reasons underlying this overgrazing-induced memory effect plant morphological plasticity. We characterized relationship between dwarf phenotype and photosynthesis...
// Lu-Lu Yu 1 , Wen Chen Xiao-Qin Lei Qin Ze-Ni Wu Qin-Jing Pan 2 Xun Zhang Bai-Feng Chang Shao-Kai 3 Hui-Qin Guo and You-Lin Qiao Department of Cancer Epidemiology, Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, P. R. China Pathology, Henan Affiliated Hospital Zhengzhou University, Office for Control Research, Zhengzhou, Correspondence to: Guo, email: Qiao, Keywords : cervical cancer; p16/Ki-67 dual staining; human papillomavirus; women; Pathology Section Received...
This paper establishes a fully automatic real-time image segmentation and recognition system for breast ultrasound intervention robots. It adopts the basic architecture of U-shaped convolutional network (U-Net), analyses actual application scenarios semantic images, adds dropout layers to U-Net reduce redundancy in texture details prevent overfitting. The main innovation this is proposing an expanded training approach obtain U-Net. output map can retain edge features tumours. Using...
844 Background: Urothelial carcinoma (UC) remains one of the most common urologic cancers, presenting challenges in both initial diagnosis and follow-up due to invasive nature traditional diagnostic procedures. Urinary cell-free DNA (ucfDNA) analysis offers a non-invasive alternative, with methylation patterns providing promising avenue for identifying tumor-derived cfDNA. This study explores utility ucfDNA methylation-based tumor fraction (mTF) early detection monitoring recurrence UC...
846 Background: Traditional diagnostic procedures for urothelial carcinoma (UC) are often limited by patient burden and reduced sensitivity, impacting accuracy. Liquid biopsy-based molecular detection, particularly through fragmentomics analysis, offers a promising supplement to clinical applications. Fragmentomics, which examines the unique fragmentation patterns of tumor DNA, can provide crucial insights into origin behavior. This study aims leverage urinary cell-free DNA (ucfDNA) enhance...
In trawling fisheries, otter boards are essential tools that expand net openings and gather fish schools. This study uses the Smoothed Particle Hydrodynamics (SPH) method to create a three-dimensional numerical model for biplane-type board. A scaled is fabricated dynamic flume experiments, validating results. Analysis with Computational Fluid Dynamics (CFD) demonstrates SPH enhances computational accuracy over traditional CFD. comprehensive analysis of hydrodynamic performance under various...
Esophageal squamous cell carcinoma (ESCC) is associated with very high regional mortality rates in several countries. Our initial test of esophageal cytology screening devices found them not sensitive enough for an early detection program. The current study tested a newly designed "mechanical" balloon and traditional Chinese inflatable balloon, followed by liquid-based cytology, to detect biopsy-proven dysplasia cancer.Participants were randomized cytologic sampler, endoscopy iodine...