A5052253348- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pharmacological Effects and Toxicity Studies
- Metal complexes synthesis and properties
- HIV/AIDS drug development and treatment
- Synthesis and biological activity
- Pregnancy and Medication Impact
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Fibroblast Growth Factor Research
- Pharmacogenetics and Drug Metabolism
- Pancreatic and Hepatic Oncology Research
- Per- and polyfluoroalkyl substances research
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Inflammatory mediators and NSAID effects
- Melanoma and MAPK Pathways
- Effects and risks of endocrine disrupting chemicals
- Ginger and Zingiberaceae research
- Acute Lymphoblastic Leukemia research
- Berberine and alkaloids research
Honeywell (United States)
2024-2025
St. John's University
2009-2017
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2014
National Institute of Allergy and Infectious Diseases
2014
The Barbara Ann Karmanos Cancer Institute
2014
Wayne State University
2014
University of Louisiana at Monroe
2014
Multidrug resistance protein 7 (MRP7, ABCC10) is a recently discovered member of the ATP-binding cassette (ABC) family which are capable conferring to variety anticancer drugs, including taxanes and nucleoside analogs, in vivo. MRP7 highly expressed non-small cell lung cancer cells, Mrp7-KO mice sensitive paclitaxel, making an attractive chemotherapeutic target cancer. However, only few inhibitors currently identified, with none them having progressed clinical trials. We used MRP7-expressing...
23-O-(1,4′-Bipiperidine-1-carbonyl)betulinic acid (BBA), a synthetic derivative of 23-hydroxybetulinic (23-HBA), shows reversal effect on multidrug resistance (MDR) in our preliminary screening. Overexpression ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 has been reported recent studies to be major factor contributing MDR. Our study results showed that BBA enhanced the cytotoxicity ABCB1 substrates increased accumulation doxorubicin or rhodamine123 overexpressing...
Phosphodiesterase type 5 (PDE5) inhibitors are widely used in the treatment of male erectile dysfunction and pulmonary hypertension. Recently, several groups have evaluated ability PDE5 for their anticancer activities. Previously, we had shown that sildenafil, vardenafil tadalafil could reverse P-glycoprotein (ATP-binding cassette B1)-mediated MDR. In present study, determined whether these potential to multidrug resistance protein 7 (MRP7; ATP-binding C10)-mediated We found sildenafil...
Abstract Saracatinib, a highly selective, dual Src/Abl kinase inhibitor, is currently in Phase II clinical trial for the treatment of ovarian cancer. In our study, we investigated effect saracatinib on reversal multidrug resistance (MDR) induced by ATP‐binding cassette (ABC) transporters vitro and vivo . Our results showed that significantly enhanced cytotoxicity ABCB1 substrate drugs overexpressing HeLa/v200, MCF‐7/adr HEK293/ABCB1 cells, an was stronger than gefitinib, whereas it had no...
Paclitaxel displays clinical activity against a wide variety of solid tumors. However, resistance to paclitaxel significantly attenuates the response chemotherapy. The ABC transporter subfamily C member 10 (ABCC10), also known as multidrug protein 7 (MRP7) efflux transporter, is major mediator resistance. In this study, we show that masitinib, small molecule stem-cell growth factor receptor (c-Kit) tyrosine kinase inhibitor, at nontoxic concentrations, in HEK293 cells transfected with...
// Rishil J. Kathawala 1,8,* , Liuya Wei 1,2,* Nagaraju Anreddy 1 Kang Chen 3,4,5,6 Atish Patel Saeed Alqahtani 7 Yun-Kai Zhang Yi-Jun Wang Kamlesh Sodani Amal Kaddoumi Charles R. Ashby Jr. and Zhe-Sheng Department of Pharmaceutical Sciences, College Pharmacy Health St. John’s University, Queens, NY, USA 2 School Biological Weifang Medical Weifang, People’s Republic China 3 Obstetrics Gynecology, Wayne State University Medicine, Detroit, Michigan, 4 Perinatology Research Branch,...
Multidrug resistance protein 7 (MRP7, ABCC10) is a recently identified member of the ATP-binding cassette (ABC) transporter family, which adequately confers to diverse group antineoplastic agents, including taxanes, vinca alkaloids and nucleoside analogs among others. Clinical studies indicate an increased MRP7 expression in non-small cell lung carcinomas (NSCLC) compared normal healthy tissue. Recent revealed paclitaxel sensitivity Mrp7−/− mouse model their wild-type counterparts. This...
ATP-binding cassette (ABC) transmembrane proteins evidently decrease the intracellular accumulation of substrate chemotherapeutic drugs by extruding them against a concentration gradient, thereby inducing drug resistance. Here we reported effect WHI-P154, an irreversible inhibitor Janus kinase 3 and epidermal growth factor receptor tyrosine kinases, on reversing ABC transporters-mediated We found that WHI-P154 significantly enhanced sensitivity ABCG2-overexpressing cells to its substrates....
Natural products are frequently used for adjuvant chemotherapy in cancer treatment. 23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA) is a synthetic derivative of 23-hydroxybutulinic (23-HBA), which natural pentacyclic triterpene and the major active constituent root Pulsatilla chinensis. We previously reported that BBA could reverse P-glycoprotein (P-gp/ABCB1)-mediated multidrug resistance (MDR). In present study, we investigated whether has potential to protein 7...
ATP-binding cassette (ABC) transporters ABCC1 (MRP1), ABCB1 (P-gp), and ABCG2 (BCRP) contribute to chemotherapy failure. The primary goals of this study were characterize the efficacy mechanism nonsteroidal anti-inflammatory drug (NSAID), sulindac sulfide, reverse mediated resistance chemotherapeutic drugs determine if sulfide can influence sensitivity independently efflux. Cytotoxicity assays performed measure ABC-expressing cell lines doxorubicin other drugs. NSAIDs tested for ability...