A5083056882- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Analysis
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Metal complexes synthesis and properties
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Pharmacological Receptor Mechanisms and Effects
- Viral Infections and Outbreaks Research
- Disaster Response and Management
- Diabetes Treatment and Management
- DNA Repair Mechanisms
- Biomedical Text Mining and Ontologies
- Biomedical and Engineering Education
- Bioactive Compounds and Antitumor Agents
- Microfluidic and Bio-sensing Technologies
- Adenosine and Purinergic Signaling
- Acute Lymphoblastic Leukemia research
- Microbial Inactivation Methods
- Glycosylation and Glycoproteins Research
- Advancements in Transdermal Drug Delivery
- Biopolymer Synthesis and Applications
Marshall B. Ketchum University
2019-2021
St. John's University
2007-2017
Touro College
2014
All the therapeutic strategies for treating cancers aim at killing cancer cells via apoptosis (programmed cell death type I). Defective endow tumor with survival. The can respond to such defects autophagy. Autophagy is a cellular process by which cytoplasmic material either degraded maintain homeostasis or recycled energy and nutrients in starvation. A plethora of evidence has shown that role autophagy tumors complex. lot effort needed underline functional status progression treatment,...
Multidrug resistance protein 7 (MRP7, ABCC10) is a recently discovered member of the ATP-binding cassette (ABC) family which are capable conferring to variety anticancer drugs, including taxanes and nucleoside analogs, in vivo. MRP7 highly expressed non-small cell lung cancer cells, Mrp7-KO mice sensitive paclitaxel, making an attractive chemotherapeutic target cancer. However, only few inhibitors currently identified, with none them having progressed clinical trials. We used MRP7-expressing...
ATP-binding cassette subfamily G member 2 (ABCG2) is a of the ABC transporter superfamily proteins, which has been implicated in development multidrug resistance (MDR) cancer, apart from its physiological role to remove toxic substances out cells. The diverse range substrates ABCG2 includes many antineoplastic agents such as topotecan, doxorubicin and mitoxantrone. expression reported be significantly increased some solid tumors hematologic malignancies, correlated poor clinical outcomes. In...
Previous reports have shown that some tyrosine kinase inhibitors (TKIs) could inhibit the ATP-binding cassette (ABC) transporters involved in multidrug resistance (MDR). Quizartinib (AC220), a potent class III receptor inhibitor (TKI), was synthesized to selectively FMS-like kinase-3 (FLT3), target treatment of acute myeloid leukemia (AML). is currently under clinical trials for FLT3 ITD and wild-type AML tested combination with chemotherapy. While non-toxic cell lines, quizartinib at 3 μM...
Chronic opioid antagonist treatment up-regulates receptors and produces functional supersensitivity. Although antagonists vary from neutral to inverse, the role of efficacy in mediating chronic effects is not known. In this study, two putative inverse agonists (naltrexone, naloxone) a (6β-naltrexol) were examined. Initially, peak effect (40 min, naltrexone naloxone; 70 6β-naltrexol) relative potency antagonize morphine analgesia determined (relative potencies = 1, 2, 16, 6β-naltrexol,...
On August 8, 2014, the World Health Organization established that current Ebola virus disease (EVD) epidemic is a Public Emergency of International Concern (PHEIC), urging global community to orchestrate their efforts control outbreak. As November 12, 2014 reported at least 5,160 lives have been lost virus. We conducted literature review in order determine underlying factors contributing emergence, rapid spread, and uncontrolled nature outbreak, first display distinct epicenter West Africa....
Abstract ABCG2 is a member of the ABC transporter superfamily, which has been implicated in development multidrug resistance (MDR) cancer. Its diverse range substrates includes many antineoplastic agents such as topotecan, doxorubicin and mitoxantrone. expression significantly increased some solid tumors hematologic malignancies, correlated to poorer clinical outcomes. In addition, distinguishing feature cancer stem cells, whereby this membrane impacts chemotherapeutic drugs. To enhance...
Abstract The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is a vital member of the ABC transporter superfamily, which has been involved in multidrug resistance (MDR) cancer. Its diverse range substrates includes many antineoplastic agents such as doxorubicin and mitoxantrone. ABCG2 expression significantly increased some solid tumors hematologic malignancies, correlated to poorer clinical outcomes. In addition, distinguishing feature cancer stem cells, whereby this membranous...
Abstract Quizartinib (AC220), a novel and potent class II receptor tyrosine kinase inhibitor that has better therapeutic pharmacokinetic profile amongst its class. is currently under clinical trials for FLT3 ITD wild-type AML tested in combination with chemotherapy. This study examined the effects of quizartinib on ABC transporter-mediated multidrug resistance (MDR). Cytotoxic studies showed 0.75, 1.5, 3 μM are three less toxic concentrations normal as well cancer cells. Out these...
Abstract Background: ARRY-334543, an ATP-competitive, selective, reversible small molecule tyrosine kinases inhibitor of ErbB1 and ErbB2, has shown superior preclinical tumor inhibitory activity to that lapatinib in a wide range cell lines xenografts dependent on ErbB signaling pathway. We conducted this study determine whether ARRY-334543 can enhance the efficacy conventional anticancer drugs through interaction with ABC transporters, major obstacle successful cancer treatment. Material...