A5016951048- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Ocular Surface and Contact Lens
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Pancreatic function and diabetes
- Nuclear Receptors and Signaling
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Genetics and Physical Performance
- Pluripotent Stem Cells Research
- Hydrogen's biological and therapeutic effects
- Injury Epidemiology and Prevention
- Platelet Disorders and Treatments
- Advancements in Transdermal Drug Delivery
- Corneal surgery and disorders
- Dialysis and Renal Disease Management
- Nuts composition and effects
First Affiliated Hospital of Zhengzhou University
2022-2024
Shandong Eye Hospital
2022-2023
Shandong First Medical University
2022-2023
Guizhou Provincial People's Hospital
2019-2023
National Institute on Aging
2019-2022
National Institutes of Health
2021-2022
Xiangya Hospital Central South University
2015-2021
Central South University
2015-2021
Hangzhou Women’s Hospital
2021
Guiyang University
2019
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but role autophagy in microglial activation during PD remains largely unclear. In this study, we showed that deletion
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset (sEOPD) in a mainland Chinese population clinical features mutation carriers. We performed multiplex ligation-dependent probe amplification assays whole-exome sequencing for 1676 unrelated patients with population, including 192 probands from families autosomal-recessive disease, 242 autosomal-dominant 1242 sEOPD (age at onset ≤ 50). According standards guidelines American College...
Parkinson's disease causes the most profound loss of aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neuron (nDAN) subpopulation. The connectivity and functionality ALDH1A1+ nDANs, however, remain poorly understood. Here, we show in rodent brains that nDANs project predominantly to rostral dorsal striatum, from which they also receive monosynaptic inputs, indicating extensive reciprocal innervations with striatal spiny projection neurons (SPNs). Functionally,...
Abstract Endocannabinoid (eCB), 2 -arachidonoyl-glycerol (2-AG), the most abundant eCB in brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of-function mutations 2-AG synthase diacylglycerol lipase β ( DAGLB ) to an early onset autosomal recessive Parkinsonism. is main human and mouse substantia nigra (SN) dopaminergic neurons (DANs). In mice, SN levels were markedly correlated with motor performance during locomotor skill acquisition. Genetic knockdown of...
Abstract Purpose This study evaluated the clinical safety and efficacy of tanfanercept (HBM9036) ophthalmic solution as a novel treatment for dry eye disease (DED) in controlled adverse environment (CAE) conducted China. Methods In single-center, double-masked, randomized, placebo-controlled study, 100 patients received 0.25% tanfanercept, or placebo, twice daily eight weeks. A mobile international CAE ® DE Model was used patient selection with standardized challenge endpoint. Primary...
Abstract Exposure to excessive manganese (Mn) causes manganism, a progressive neurodegenerative disorder similar idiopathic Parkinson’s disease (IPD). The detailed mechanisms of Mn neurotoxicity in nerve cells, especially dopaminergic neurons are not yet fully understood. Meanwhile, it is unknown whether there exists potential antagonist or effective drug for treating neuron damage manganism. In the present study, we report discovery an HIF prolyl-hydroxylase inhibitor, DMOG...
Objectives To access the epidemiological characteristics of elderly people using emergency medical services (EMS) in Beijing, as a consequence injurious falls, and association between an ageing population falls. Design A longitudinal observational study based on Beijing EMS data. Setting All citizens aged 60 years or above who used from 2010 to 2017 China. Participants During 2017, 2516 128 Beijing. Of these, 1528 938 under were excluded remaining 987 190 included our study. Methods Data...
Abstract 5-Methylcytosine (5mC), generated through the covalent addition of a methyl group to fifth carbon cytosine, is most prevalent DNA modification in humans and functions as critical player regulation tissue cell-specific gene expression. 5mC can be oxidized 5-hydroxymethylcytosine (5hmC) by ten–eleven translocation (TET) enzymes, which enriched brain. Alzheimer’s disease (AD) common neurodegenerative disorder, several studies using samples collected from Caucasian cohorts have found...
Objective Anxiety symptoms are prevalent neuropsychiatric manifestations in Parkinson’s disease (PD) and impact the development of motor complications. Our aim was to evaluate association GBA variants with anxiety early PD cohort. Methods This cohort study used data from Parkinson Progression Marker Initiative. The primary outcome assessed by State–Trait Inventory (STAI). between longitudinal change STAI total score examined using linear mixed-effects model, progression Cox survival...
Parkinson’s disease (PD) is a prevalent degenerative movement disorder largely attributed to the dysfunction of dopamine transmission in basal ganglia. However, role endocannabinoid (eCB) system (ECS) PD pathology and symptomatology often overlooked discussions. Recent research, including our own, has identified multiple homozygous loss-of-function variants diacylglycerol lipase β (DAGLB), an enzyme involved synthesis 2-arachidonoyl-glycerol (2-AG) - most abundant eCB brain individuals with...
Purpose To compare the surgical outcomes of combined penetrating keratoplasty (PK) and cataract surgery with those sequential (cataract after PK) for herpes simplex keratitis (HSK). Methods The medical records consecutive patients diagnosed HSK who underwent or PK in active stable stages between June 2015 2022 were reviewed retrospectively. Complications, graft survival, endothelial cell density (ECD), final BCVA compared analyzed both methods each stage. Results A total 171 eyes enrolled,...
Rapid eye movement (REM) sleep behavior disorder (RBD) is a common non-motor symptom of PD. However, the association between SNCA rs3910105 genotype and RBD in Parkinson's disease (PD) remains unclear.This study used Progression Markers Initiative (PPMI) data included 270 patients with newly diagnosed PD without who were divided into C carriers (CC+CT; n = 187) TT (n 83). They followed up for 5 years to identify development RBD. To investigate influence cerebrospinal fluid (CSF)...
Abstract 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid (eCB) in brain, regulates diverse neural functions. However, whether 2-AG deficiency contributes to Parkinson’s disease (PD) and nigral dopaminergic neurons (DANs) dysfunction is unclear. Diacylglycerol lipase α β ( DAGLA DAGLB ) mediate biosynthesis of 2-AG. Using homozygosity mapping whole-exome sequencing, we linked multiple homozygous loss-of-function mutations a form early-onset autosomal recessive PD. We then...
Objective: To explore the effect of hemoperfusion (HP) combined with hemodialysis (HD) (HD+HP) on protein energy wasting (PEW) and long-term prognosis in patients maintenance HD (MHD). Methods: A prospective multicenter cohort study was conducted. Adult MHD who completed PEW assessment underwent regular dialysis between July 2015 2021 at 23 centers Guizhou Province were selected. Demographic characteristics, physical indicators, laboratory 3-day diet diary HP treatment data subjects...
More than 100 years has passed since Oppenheim firstly named the term dystonia in 1911, definition of which that adopted by doctors is outdated and classification not specific. Albanese, et al proposed new 2013, help a lot to guide diagnosis treatment dystonia. Recently, there have been development recognition on This review summarizes definition, classification, DOI: 10.3969/j.issn.1672-6731.2017.01.005
To detect mutation of LBR gene in a pedigree affected with Pelger-Huёt anomaly (PHA) and to explore its clinical characteristics.Genomic DNA was extracted from the healthy controls. The 14 exons were subjected PCR amplification Sanger sequencing. Suspected mutations verified other family members 100 Polyphen-2 SIFT software used predict effect mutation, Swiss-model simulate protein structure.Three patients found carry c.893G>A exon 8 gene, which resulted substitution 298th amino acid residue...