A5058383276- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Parallel Computing and Optimization Techniques
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Ophthalmology and Visual Impairment Studies
- Memory and Neural Mechanisms
- Distributed and Parallel Computing Systems
- Neurogenesis and neuroplasticity mechanisms
- Visual perception and processing mechanisms
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Coding theory and cryptography
- Cryptographic Implementations and Security
- Embedded Systems Design Techniques
- Neurotransmitter Receptor Influence on Behavior
- Optical Systems and Laser Technology
- Neurological disorders and treatments
- Radiative Heat Transfer Studies
- Nerve injury and regeneration
- Gas Dynamics and Kinetic Theory
- Chaos-based Image/Signal Encryption
- Psychedelics and Drug Studies
- Zebrafish Biomedical Research Applications
National Institute on Drug Abuse
2016-2025
University of North Dakota
2021-2025
ZhengZhou Shengda University Of Economics, Business & Management
2023
National Institutes of Health
2016-2022
University of Chinese Academy of Sciences
2010-2021
ORCID
2021
Beijing Aerospace Flight Control Center
2015
Institute of Optics and Electronics, Chinese Academy of Sciences
2012
Chinese Academy of Sciences
2006-2012
Chongqing University
2009-2011
Abstract Visualizing neural activity from deep brain regions in freely behaving animals through miniature fluorescent microscope (miniscope) systems is becoming more important for understanding encoding mechanisms underlying cognitive functions. Here we present our custom‐designed miniscope GRadient INdex (GRIN) lens system that enables simultaneously recording hundreds of neurons months. This article includes design, the surgical procedure GRIN implantation, mounting on head a mouse, and...
Parkinson's disease causes the most profound loss of aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neuron (nDAN) subpopulation. The connectivity and functionality ALDH1A1+ nDANs, however, remain poorly understood. Here, we show in rodent brains that nDANs project predominantly to rostral dorsal striatum, from which they also receive monosynaptic inputs, indicating extensive reciprocal innervations with striatal spiny projection neurons (SPNs). Functionally,...
Learning when to initiate or withhold actions is essential for survival and requires integration of past experiences with new information adapt changing environments. While stable prelimbic cortex (PL) ensembles have been identified during reward learning, it remains unclear how they contingencies shift. Does the same ensemble adjust its activity support behavioral suppression upon omission, a distinct recruited this learning? We used single-cell calcium imaging longitudinally track PL...
Dorsal striatum is important for movement control and motor skill learning. However, it remains unclear how the spatially temporally distributed striatal medium spiny neuron (MSN) activity in direct indirect pathways (D1 D2 MSNs, respectively) encodes Combining miniature fluorescence microscopy with an accelerating rotarod procedure, we identified two distinct MSN subpopulations involved In both D1 observed neurons that displayed tuned to acceleration during early stages of trials, as well...
The concept of a critical period for visual development early in life during which sensory experience is essential to normal neural now well established. However recent evidence suggests that limited degree plasticity remains after this and into adulthood. Here, we ask the question, "what limits adulthood?" Although limit has been assumed be due factors, show optical quality retinal image ultimately brain potential change. We correct high-order aberrations (HOAs) normally present eye's...
Recent clinical breakthroughs hold great promise for the application of psilocybin in treatments psychological disorders, such as depression, addiction, and obsessive-compulsive disorder. Psilocybin is a psychedelic whose metabolite, psilocin, 5-HT2A receptor agonist. Nevertheless, underlying mechanisms effects on brain are not fully illustrated, cell type-specific circuit understood. Here, we combined single-nucleus RNA-seq with functional assays to study long-term orbitofrontal cortex...
Miniature fluorescence microscopes are becoming an increasingly established tool to investigate neural circuits in freely moving animals. In this work we present a lightweight one-photon microscope capable of imaging at different focal depths. The plane can be changed dynamically by modulating the pulse width control signal variable focus liquid lens, which is synchronized image sensor enable changing between frames. system was tested GCaMP7f expressing neurons mouse medial prefrontal cortex...
To investigate the effect on contrast sensitivity function (CSF) of correcting residual wavefront aberrations in myopic and keratoconic subjects wearing rigid gas permeable (RGP) contact lenses.Seventeen eyes 16 20 19 were included this study. All habitually corrected with RGP lenses. The lens-wearing compensated by an adaptive optics (AO) system. sensitivities measured through a 4-mm artificial pupil at spatial frequencies 2, 4, 8, 16, 32 cycles per degree (cpd) during lens wear for groups,...
Dystrobrevin-binding protein 1 (Dtnbp1) is one of the earliest identified schizophrenia susceptibility genes. Reduced expression DTNBP1 commonly found in brain areas schizophrenic patients. Dtnbp1-null mutant mice exhibit abnormalities behaviors and impairments neuronal activities. However, how diminished contributes to clinical relevant features remains be illustrated. Here, using a conditional Dtnbp1 knockout mouse line, we an vivo schizophrenia-relevant function pyramidal neurons medial...
In this work we propose an open source, cost-effective motorized swivel for behavioral and neural recordings in small rodents, offering a flexible solution managing cable twisting tangling variety of experimental settings with minimal human supervision.•The device operates independently the data acquisition system, it can be controlled through any popular platform such as Arduino or Raspberry Pi.•All mechanical parts are 3D-printed, allowing to customize design fit specific needs,...
Rousettus leschenaulti is an abundant species in many countries of South-East Asia, including south China. We isolated seven microsatellite loci R. from genomic DNA enriched for CA repeats with the library method. A total 56 samples a population Guangxi Province China were tested these markers. The polymorphism ranged to 16 alleles, and observed heterozygosity was 84-94%. It first time markers characterized leschenaulti, can be important tool analysing structure genotypic diversity.
Mislocalization of TAR DNA binding protein 43 kDa (TARDBP, or TDP-43) is a principal pathological hallmark identified in cases neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As an RNA protein, TDP-43 serves the nuclear compartment to repress non-conserved cryptic exons ensure normal transcriptome. Multiple lines evidence from animal models human studies support view that loss leads neuron loss, independent its cytosolic aggregation....
Electrically pumped semiconductor mode-locked lasers (SMLs) are promising in a wide range of applications due to compact size, high energy efficiency, and low cost. However, the long gain interaction length increases spontaneous emission noise. In this Letter, an external cavity structure is adopted improve SML noise performance, as well flexibility adjust repetition rate. Two SMLs with rates 255 MHz 10 GHz demonstrated. For SML, signal-noise-ratio radio frequency linewidth fundamental reach...