A5037361531- Glycosylation and Glycoproteins Research
- Retinal Diseases and Treatments
- Tea Polyphenols and Effects
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocular Oncology and Treatments
- Dialysis and Renal Disease Management
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Sperm and Testicular Function
- Aldose Reductase and Taurine
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Meta-analysis and systematic reviews
- Nutrition and Health in Aging
- Supramolecular Self-Assembly in Materials
- Heavy Metals in Plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive Biology and Fertility
- Neurological Disease Mechanisms and Treatments
Guizhou Provincial People's Hospital
2021-2023
First Affiliated Hospital of Zhengzhou University
2019-2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2020
Chongqing Medical University
2017-2020
Academy of Military Medical Sciences
2013
Aberrant expression of microRNAs plays an important role in the pathogenesis and progression retinoblastoma. MiR-25, a member miR-106b˜25 cluster, has been reported to be abnormally expressed retinoblastoma, but exact it remains unclear. In our study, we found that miR-25-3p was upregulated retinoblastoma tissues cell lines. Enforced line WERI-RB-1 increased growth, colony formation, anchorage-independent migration invasion vitro tumor xenograft growth vivo. contrast, inhibited Y79...
Retinal pigment epithelium (RPE) cellular senescence is an important process in degenerative retinal disorders. Grape seed proanthocyanidin extract (GSPE) alleviates senescence-related disorders; however, the potential effects of GSPE intake on RPE through regulating NAMPT/SIRT1/NLRP3 pathway remain unclear.The NAMPT expression and NAD+ contents were detected with Western blot assay kit both in-vivo in-vitro AMD models. Senescence-related biomarkers, including p16, p21 expressions β-gal...
Diabetic retinopathy (DR) is a most common microvascular complication and regarded as the leading cause of blindness in working age population. The involvement miR-200a various disorders has become recognized, objective this study was to identify protective effect development DR.The contents its potential target gene, PDZ LIM domain protein 1 (PDLIM1), were detected both in-vivo in-vitro DR models. Retinal leakage inflammatory factor concentrations after vitreous injections miR-200a/PDLIM1...
Fluorescent carbonaceous nanospheres (CDs) have gained significant attention because of their promising applications, especially in biology and medicine, due to unique properties. However, the application CDs noninvasive imaging diseased tissues has been restricted by poor targeting efficiency CDs. In this study, were prepared from sucrose glutamic acid with a particle size 122.5 nm. Due quantum confinement nanoparticles, exhibited emission 450 600 nm upon excitation at approximately 400...
We, the Editors and Publisher of journal Artificial Cells, Nanomedicine, Biotechnology, have retracted following article:Wencui Wan, Weiwei Yang Long, Qiuming Li, Xuemin Jin, Guangming Fengyan Zhang & Yong Lv. (2020). Physcion 8-O-β-glucopyranoside exerts protective roles in high glucose-induced diabetic retinopathy via regulating lncRNA NORAD/miR-125/STAT3 signalling. 48(1), 463–472, DOI: 10.1080/21691401.2019.1709861Since publication, concerns been raised about integrity data article. When...
Abstract As an energy-sensitive post-translational modification, O-GlcNAcylation plays a major role in endothelial nitric oxide synthase (eNOS) activity regulation. However, effects of glucose deprivation on eNOS and the presence novel sites under remain unknown. Hence, we aim to determine eNOS. Bovine aortic cells (BAECs) Sprague–Dawley rats were induced by their was subjected immunoblotting. transfected purified pull-down assay immunoprecipitation respectively. Novel predicted HPLC–MS...
BACKGROUND Melatonin is reported to be related diabetes mellitus (DM) risk; however, the effect of melatonin on diabetic retinopathy (DR) risk remains unclear. AIM The aim this study was determine DR risk. METHODS A hospital-based case-control conducted from January 2020 June 2020. assessed using Diabetic Retinopathy preferred practice pattern (PPP)-updated 2019 criteria. participants were divided into DM cases without (NDR) group, non-proliferative (NPDR) group and proliferative (PDR)...
Objective: To explore the association of systemic immune-inflammation index (SII) with protein-energy wasting (PEW) and prognosis in maintenance hemodialysis (MHD) patients. Methods: A multicenter cohort study was conducted 11 centers Guizhou province from July to September 2019. The patients were divided into PEW group non-PEW group. After 12 months follow-up, death endpoint event. Multivariate logistic regression analysis used assess independent risk factors MHD receiver operating...
Objective: To explore the effect of hemoperfusion (HP) combined with hemodialysis (HD) (HD+HP) on protein energy wasting (PEW) and long-term prognosis in patients maintenance HD (MHD). Methods: A prospective multicenter cohort study was conducted. Adult MHD who completed PEW assessment underwent regular dialysis between July 2015 2021 at 23 centers Guizhou Province were selected. Demographic characteristics, physical indicators, laboratory 3-day diet diary HP treatment data subjects...
Objective To research the correlation between estradiol in seminal plasma and semen parameters of male infertile patients to explore value predicting sperm quality. Methods A total 86 infertility men who visited reproductive center our hospital from October December 2018 were randomly selected measured according WHO laboratory standard. We also tested by chemiluminescence. The divided into four groups parameters: oligozoospermia (group 1, n=12), asthenospermia 2, n=24),...
Abstract Background O-GlcNAcylation, an energy-sensitive post-translational modification, plays a major role in endothelial nitric oxide synthase (eNOS) activity regulation. However, the effect of hypoglycemia on eNOS O-GlcNAcylation and whether exists novel sites under is unknown. Hence, we endeavored to determine effects eNOS. Method Bovine aortic cells (BAECs) Sprague-Dawley rats were treated by hypoglycemia, using immunoblotting measure their O-GlcNAcylation. transfected purified...
Abstract Background: Cellular senescence of retinal pigment epithelium (RPE) cell was an important cause degenerative disorders, however, the potential effects grape seed proanthocyanindin extract (GSPE) through regulating NAMPT/SIRT1/NLRP3 pathway remained unclear. Methods: The GSPE on cellular biomarkers as well NAMPT and NAD+ contents were detected in both in-vivo in-vitro RPE models. protection treatment mitochondrial homeostasis barrier function cells with mtDNA lesions, JC-1 staining,...