Alzheimer's disease (AD) is a neurodegenerative associated with amyloid-β (Aβ) deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) gut microbiota imbalance. Resveratrol (Res) has neuroprotective properties, but its bioavailability

Alzheimer's disease (AD), the most common neurodegenerative disease, is caused by an accumulation of amyloid-β (Aβ) plaque deposits in brains. Evidence increasingly showing that epigallocatechin-3-gallate (EGCG) can partly protect cells from Aβ-mediated neurotoxicity inhibiting Aβ aggregation. In order to better understand process aggregation and amyloid fibril disaggregation reduce cytotoxicity EGCG at high doses, we attached onto surface selenium nanoparticles (EGCG@Se). Given low delivery...

The structural changes of amyloid-beta (Aβ) from nontoxic monomers into neurotoxic aggregates are implicated with pathogenesis Alzheimer's disease (AD). Over the past decades, weak disaggregation ability and low permeability to blood-brain barrier (BBB) may be main obstacles for major Aβ aggregation blockers. Here, we synthesized penetratin (Pen) peptide loaded poly(ethylene glycol) (PEG)-stabilized gold nanostars (AuNS) modified ruthenium complex (Ru@Pen@PEG-AuNS), Ru(II) as luminescent...

Neuroinflammation plays a critical role in Alzheimer's disease (AD). However, it is still unknown if neuroinflammation can be effectively treated using selenium nanoparticles (SeNPs) with different surface modifications. In this study, SeNPs were coated dihydromyricetin (DMY), natural polyphenol, to obtain DMY@SeNPs. Given that DMY@SeNPs are unstable under physiological conditions, they decorated step-by-step chitosan (CS/DMY@SeNPs) and the blood brain barrier (BBB) targeting peptide Tg...

Aβ aggregation-related neuroinflammation and imbalance of brain glucose homeostasis play important roles in the pathological process Alzheimer's disease (AD). Chlorogenic acid (CGA) is one most common dietary polyphenols with neuroprotective effects. However, due to low bioavailability CGA, its application dose usually high vivo. In our previous study, spherical selenium nanoparticles act as drug carriers improve bioactivity resveratrol. Here, brain-targeting peptide (TGN peptide) CGA were...

Inhibition of amyloid β (Aβ) aggregation holds considerable promise as a therapeutic strategy for Alzheimer's disease (AD). However, successful inhibition is hard to achieve due the blood-brain barrier (BBB) and non-selective distribution drugs. Herein, two targeting peptides (LPFFD TGN) were conjugated selenium nanoparticles (SeNPs). We found that concentration ratio LPFFD TGN taken 1 : could form most effective dual-functional SeNPs (L1T1-SeNPs) inhibiting Aβ crossing BBB. L1T1-SeNPs can...

Deposition of amyloid-β (Aβ) aggregates and formation neurotoxic reactive oxygen species (ROS) are significant pathological signatures Alzheimer's disease (AD). Resveratrol (Res) is an antioxidant with the potential to treat AD. However, bioavailability solubility Res very low it cannot entirely inhibit Cu2+ -induced Aβ42 aggregation at concentration. Herein, we combine unique Aβ absorption property selenium nanoparticles natural agent form Res@SeNPs. Our in vitro biological evaluation...

Angiogenesis is crucial for tumor growth. Thus, inhibiting angiogenesis represents a promising avenue preventing This study investigated the anti-angiogenesis and anti-tumor effects of 8-hydroxyquinoline ruthenium(II) complexes [Ru(bpy)2(8-HQ)](+) (BQ) [Ru(phen)2(8-HQ)](+) (PQ). The results showed that both compounds, especially PQ, suppressed proliferation, migration, invasion, tube formation microvessel growth endothelial cells in vitro. PQ also inhibited human hepatocellular liver...

Functionalization can promote the uptake of nanoparticles into cancer cells via receptor-mediated endocytosis, enabling them to exert their therapeutic effects. In this paper, epigallocatechin gallate (EGCG), which has a high binding affinity 67 kDa laminin receptor (67LR) overexpressed in HCC cells, was employed present study functionalized ruthenium (RuNPs) loaded with luminescent complexes achieve antiliver efficacy. [Ru(bpy)2(4-B)] (ClO4)2·2H2O (RuBB)-loaded EGCG-RuNPs (bpy =...

Background Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus that manifests as chronic, non-healing wounds have significant impact on patients quality life. Identifying key molecular targets associated with DFUs could help develop targeted therapies to promote wound healing and prevent further complications. The CXCR4 gene is known play role in cell migration, immunology response, tissue repair, thus may be an important target for DFU treatment. Methods We used the...

A neuropathological hallmark of Alzheimer's disease (AD) is aggregation a forty-residue peptide known as amyloid beta forty (Aβ40). While past work has indicated that blocking Aβ40 could be an effective strategy for the treatment AD, developing therapies with this goal been met limited success. Polyoxometalates (POMs) have previously investigated their anti-viral and anti-tumoral properties we report here three representative POM nanoclusters synthesized use against aggregation. Through...

The deposition of amyloid-β (Aβ) plaques and formation neurotoxic reactive oxygen species (ROS) is a significant pathological signature Alzheimer's disease (AD). Herein, novel strategy reported for combining the unique Aβ absorption property selenium nanoparticles with natural antioxidant agent chlorogenic acid (CGA) to form CGA@SeNPs. in vitro biological evaluation revealed that CGA could clear ROS induced by Aβ40 aggregates, but it did not inhibit aggregation cell membrane damage which...

The combination of CGA and caffeine exhibits anti-obesity effects regulates lipid metabolism<italic>via</italic>the AMPKα-LXRα/SREBP-1c signaling pathway in mice with high-fat diet-induced obesity.

This study was to investigate whether Smilax china L. polyphenols (SCLP) could ameliorates high fat/high sucrose (HFHS)-induced obesity and inflammation in mice by modulation of gut microbiota. SCLP extracted from rhizome identified liquid chromatography tandem mass spectrometry (LC–MS/MS). Then, C57BL/6J were fed with Chow diet, HFHS supplement or Orlistat for 12 weeks. In general, three phenolic acids flavonoids SCLP. The treatment efficiently improved glucose tolerance reduced body...