A5076061762- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Biofuel production and bioconversion
- Polysaccharides and Plant Cell Walls
- Polysaccharides Composition and Applications
- Fungal Biology and Applications
- Cardiac Health and Mental Health
- Plant nutrient uptake and metabolism
- Algal biology and biofuel production
- Traditional Chinese Medicine Analysis
- Lipoproteins and Cardiovascular Health
- Enzyme Production and Characterization
- Sleep and related disorders
- Chromium effects and bioremediation
- CRISPR and Genetic Engineering
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Adipose Tissue and Metabolism
- Coronary Interventions and Diagnostics
- Diabetes Management and Research
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Legume Nitrogen Fixing Symbiosis
- Cardiac Imaging and Diagnostics
- Proteins in Food Systems
Jiangxi Agricultural University
2016-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2018-2024
Beijing University of Chinese Medicine
2015-2024
Mayo Clinic
2021-2024
Xiyuan Hospital
2018-2024
Mayo Clinic in Arizona
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Tianjin Institute of Industrial Biotechnology
2014-2023
Chinese Academy of Sciences
2014-2023
WinnMed
2023
Over the past 3 years, CRISPR/Cas9 system has revolutionized field of genome engineering. However, its application not yet been validated in thermophilic fungi. Myceliophthora thermophila, an important biomass-degrading fungus, attracted industrial interest for production efficient thermostable enzymes. Genetic manipulation is crucial metabolic engineering and to unravel mechanism lignocellulose deconstruction. The lack a powerful, versatile genome-editing tool impeded broader exploitation...
M. Elisabeth Koopman-Verhoeff, MSc; Michiel A. van den Dries, Judith J. Seters, BSc; Maartje P. C. Luijk, PhD; Henning Tiemeier, MD, Annemarie I. Luik, PhD
Necroptosis, a recently discovered programmed cell death, has been pathologically linked to various diseases and is thus promising target for treating diseases. However, comprehensive objective report on the current status of entire necroptosis research lacking. Therefore, this study aims conduct bibliometric analysis quantify identify quo trending issues in last decade.Articles were acquired from Web Science Core Collection database. We used two tools (CiteSpace VOSviewer) individual impact...
Evidence regarding the nature and prevalence of 24-hour activity pattern phenotypes in older adults, especially those related to depression symptoms cognition, is needed guide development targeted mechanism research behavioral interventions.To identify subgroups adults with similar rhythm characteristics characterize associated cognitive performance.From January March 2022, a cross-sectional analysis 2011-2014 National Health Nutrition Examination Survey (NHANES) accelerometer study was...
To evaluate the association between dietary inflammatory index (DII) and Atherosclerotic cardiovascular disease (ASCVD) among U.S. adults.We collected data from National Health Nutrition Examination Survey (NHANES) 1999 2018. Adults who reported complete information to diagnose ASCVD calculate DII were included. We used three models differentially adjust covariates, including age, sex, race or ethnicity, education level, smoking status, poverty, insurance, body mass index, hyperlipemia,...
Msn2/4 transcription factors in some fungi have null effects on virulence and cellular stress responses. Here we found that the transcriptional regulation of Msn2 orthologs is vital for conidiation, multi-stress responses Beauveria bassiana (Bb) Metarhizium robertsii (Mr), which lack Msn4 orthologs. Compared to wild-type complemented strains each fungus with all similar phenotypes, ΔBbmsn2 ΔMrmsn2 showed remarkable defects conidial yield (∼40% decrease) (∼25% decrease). Both delta mutants...
D-glucose, D-xylose and L-arabinose are the three major monosaccharides in plant cell walls. Complete utilization of all sugars is still a bottleneck for second-generation cellulolytic bioethanol production, especially L-arabinose. However, little known about gene expression profiles during fungi comparison genome-wide fungal response to these has not yet been reported.Using next-generation sequencing technology, we have analyzed transcriptome N. crassa grown on versus D-xylose, with...
The glucose dual-affinity transport system (low- and high-affinity) is a conserved strategy used by microorganisms to cope with natural fluctuations in nutrient availability the environment. glucose-sensing uptake processes are believed be tightly associated cellulase expression regulation cellulolytic fungi. However, both identities functions of major molecular components this evolutionarily filamentous fungi remain elusive. Here, we systematically identified characterized model fungus...
Cellulosic biomass is a promising resource for bioethanol production. However, various sugars in plant hydrolysates including cellodextrins, cellobiose, glucose, xylose, and arabinose, are poorly fermented by microbes. The commonly used ethanol-producing microbe Saccharomyces cerevisiae can usually only utilize although metabolically engineered strains that xylose have been developed. Direct fermentation of cellobiose could avoid glucose repression during fermentation, but applications an...
Extremely low diastolic blood pressure has been reported to be associated with increased adverse cardiovascular events (ie, the J-shape phenomenon); however, current US guidelines recommend an intensive target of less than 130/80 mm Hg without mentioning lower limits pressure.
Abstract Background Rest-activity rhythm (RAR), a manifestation of circadian rhythms, has been associated with morbidity and mortality risk. However, RAR patterns in the general population specifically role demographic characteristics pattern have not comprehensively assessed. Therefore, we aimed to describe among non-institutionalized US adults age, sex, race/ethnicity variation using accelerometry data from nationally representative population. Methods This cross-sectional study was...
Lignocellulolytic fungal cells suffer endoplasmic reticulum (ER) stress during lignocellulase synthesis; however, an understanding of this integrated process on a genome-wide scale remains poor. Here, we undertook systematic investigation in Neurospora crassa (N. crassa) using transcriptomic analysis coupled with genetic screens.