A5100735218- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Natural Compounds in Disease Treatment
- Infectious Diseases and Tuberculosis
- Ferroptosis and cancer prognosis
- Brucella: diagnosis, epidemiology, treatment
- Inflammatory Biomarkers in Disease Prognosis
- Respiratory viral infections research
- Pituitary Gland Disorders and Treatments
- Facial Rejuvenation and Surgery Techniques
- SARS-CoV-2 and COVID-19 Research
- Heart rate and cardiovascular health
- Intracerebral and Subarachnoid Hemorrhage Research
- Vitamin K Research Studies
- Effects of Environmental Stressors on Livestock
- Cell death mechanisms and regulation
Army Medical University
2025
Daping Hospital
2025
Beijing Chest Hospital
2022-2023
Capital Medical University
2022-2023
Beijing Tongren Hospital
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Key Laboratory of Guangdong Province
2023
Weatherford College
2023
Extremely low diastolic blood pressure has been reported to be associated with increased adverse cardiovascular events (ie, the J-shape phenomenon); however, current US guidelines recommend an intensive target of less than 130/80 mm Hg without mentioning lower limits pressure.
To explore the effectiveness and feasibility of double-row transfixion suture lower uterine segment in cesarean section (CS) patients with pernicious placenta previa complicated by accrete spectrum disorder. This retrospective study included 91 women who received CS for spectrum, which was suggested preoperative ultrasound MRI assessment, confirmed operation or postoperative pathology. Preoperative ultrasonographic scores were > 6 all patients. Of them, 47 (study group), remaining 44...
Several clinical studies demonstrate that there exist other immune checkpoints overexpressed in some PD-1 inhibitor-resistant tumor patients. Among them, Lymphocyte-activation gene 3 (LAG-3) is one of the important checkpoint molecules and has been clinically demonstrated to have synergistic anti-tumor effects combination with antibody. In this study, we designed a novel 'knob-in-hole' PD-1/LAG-3 bispecific antibody (BsAb) YG-003D3. conclusion, BsAb maintained similar affinity thermal...
Abstract Progression of hepatocellular carcinoma involves multiple genetic and epigenetic alterations that promote cancer invasion metastasis. Our recent study revealed hyperphosphorylation ezrin promotes intrahepatic metastasis in vivo cell migration vitro. Celastrol is a natural product from traditional Chinese medicine which has been used treating liver cancer. However, the mechanism action underlying celastrol treatment was less clear. Here we show ROCK2 novel target inhibition...
Background Cervical cancer is one of the most common cancers in women worldwide. Emerging evidence suggests that kin17 a tumor-promoting protein some types solid tumors. However, whether contributes to cervical carcinogenesis remains unknown. Methods Kin17 expression clinical samples from Guangdong Women and Children's Hospital Health Institute was detected by immunohistochemical staining. A series functional experiments including 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium...
At present, immunotherapy is a very promising treatment method for lung cancer patients, while the factors affecting response are still controversial. It crucial to predict efficacy of squamous carcinoma patients who received immunotherapy.In our retrospective study, we enrolled at Beijing Chest Hospital from January 2017 November 2021. All were grouped into two cohorts randomly, training cohort (80% total) and test (20% total). The was used build neural network models assess outcome in...
SARS-CoV-2 Omicron sublineages escape most preclinical/clinical neutralizing antibodies in development, suggesting that previously employed antibody screening strategies are not well suited to counteract the rapid mutation of SARS-CoV-2. Therefore, there is an urgent need screen better broad-spectrum antibody. In this study, a comprehensive approach design inhibitors against both SARS-CoV-1 and by leveraging structural diversity nanobodies proposed. This includes de novo fully human nanobody...
The superior sagittal sinus (SSS) and transverse are the major dural sinuses that receive a considerable amount of venous drainage. occlusion them has been suggested to cause intracranial hypertension, hemorrhage, lead potentially fatal consequences.We reported 35-year-old woman with headache presented our emergency department decreased level consciousness epileptic seizures. examination speech, higher mental function, cranial nerve were normal. Computed tomography (CT) demonstrated both...
Abstract Background This study aimed to evaluate the association between preoperative hs-cTnI and long-term mortality major adverse cardiovascular events (MACE) in colorectal cancer patients. Methods single-center retrospective cohort included 1105 consecutive patients who received tumor resection surgery January 2018 June 2020. Inclusion criteria were an age ≥ 18 years had been tested for on admission within 7 days prior surgery. Exclusion emergent surgery, failure hospital death, there was...
Remarkably, the anti-cancer efficacy of immunotherapy in lung adenocarcinoma (LUAD) has been demonstrated. However, predicting beneficiaries this expensive treatment is still a challenge.A group patients (N = 250) diagnosed with LUAD and receiving were retrospectively studied. They randomly divided into training dataset (80%) test (20%). The was utilized to train neural network models predict patients' objective response rate (ORR), disease control (DCR), responders (progression-free...
A longer duration of hypertension (HTN) has been suggested to be associated with a greater risk cardiovascular disease (CVD). Whether such an association is similar for mortality risk, and whether HTN CVD/mortality beyond blood pressure (BP) control levels are yet assessed. We aimed examine the associations combination systolic (SBP)/diastolic (DBP) risks CVD all-cause mortality.We used data on ∼450,000 UK residents. Participants were categorized by status duration. The primary outcome was...
Abstract Sympathetic activation contributes to the progression of hypertension and chronic kidney disease (CKD). Ablation renal sympathetic nerves lowers blood pressure (BP) preserves function in patients with CKD uncontrolled by reducing nerve activity. But whether this approach is safe effective Chinese unknown. We performed an observational study eight stages from 1 5, office BP ≥150/90 mmHg, while on at least three antihypertensive drug classes including a diuretic, diagnosis confirmed...
Introduction: In some developing countries, tuberculosis and brucellosis, which are commom causes of spinal infections, still common infectious diseases. However, co-occurrence brucellosis is rare.
 Methodology: We report a case 47-year-old male engaged in aquaculture with medical history numbness, weakness, fever, night sweats both upper limbs for about 10 days. Serum agglutination test (SAT) Brucella revealed brucella infection. Cervical computed tomography (CT) scan magnetic...
Abstract Background C‐reactive protein to albumin ratio (CRP/Alb ratio, CAR) has been suggested as a potential prognostic biomarker in lung cancer. This updated systematic review and meta‐analysis aimed assess the association between CAR cancer prognosis current literature. Methods A search of databases was conducted identify relevant studies published up April 2023. Pooled hazard ratios (HRs) 95% confidence intervals (CIs) were calculated overall survival (OS) progression‐free (PFS)...
Immunotherapy represented by immune checkpoint inhibitors (ICIs) has become the standard treatment for patients with non-oncogenic advanced non-small cell lung cancer (NSCLC). While is most prevalent in elderly patients, these are rarely included pivotal clinical trial studies. We aimed to describe efficacy and safety of immunotherapy "real-world".The data older NSCLC younger who received between July 2018 October 2021 were retrospectively analyzed objective response rate (ORR)...
As the first-line drug for treatment of HER2-positive metastatic gastric cancer (GC), Herceptin exhibits significant therapeutic efficacy. However, acquired resistance limits benefit patients, in which molecular mechanisms remain to be further determined.Quantitative real-time polymerase chain reaction was performed detect mRNA levels ARPP-19 and CD44 GC cells. Protein were determined using Western blot IHC staining. MTT soft agar colony formation assays used measure cell proliferation....
To evaluate RV longitudinal function in pulmonary hypertension (PH) patients by Two-dimensional strain (2DS). 41 with PH were prospectively studied along 40 control patients. 2DS and right heart catheterization performed, peak systolic strain(S) rate (SRs) obtained from basal to apical free wall calculated. Deformation indices compared values of conventional echocardiography the use linear regression. (1) S, SRs all segments group significantly lower than those (P <0.05); middle segment...